Zobrazeno 1 - 10
of 254
pro vyhledávání: '"J B Watson"'
Autor:
Marine Z. C. Hatit, Linus F. Reichenbach, John M. Tobin, Filipe Vilela, Glenn A. Burley, Allan J. B. Watson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a common bioconjugation technique; however oxidative degradation and residual copper may limit its use. Here, the authors show that ppm levels of Cu, generated in situ by solvent-mediated pi
Externí odkaz:
https://doaj.org/article/677a409525194539ad2bf5ef41b319c1
Autor:
Mairi M. Littleson, Christopher M. Baker, Anne J. Dalençon, Elizabeth C. Frye, Craig Jamieson, Alan R. Kennedy, Kenneth B. Ling, Matthew M. McLachlan, Mark G. Montgomery, Claire J. Russell, Allan J. B. Watson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Development of comprehensive structure–activity relationships for coronatine has been a major goal in the agrochemical industry. Here, the authors report the gram-scale production and structure–activity relationship of parent coronafacic acid and
Externí odkaz:
https://doaj.org/article/75c58f1cf7984677b6fa1c5db1fec3b8
Autor:
Kirsty L. Wilson, Alan R. Kennedy, Jane Murray, Ben Greatrex, Craig Jamieson, Allan J. B. Watson
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2005-2011 (2016)
Pd-catalysed C–C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the dri
Externí odkaz:
https://doaj.org/article/bb7a8d413b8b47c48dc16cf8a5185f2a
Autor:
John M. Halford‐McGuff, Eva M. Israel, Matthew J. West, Julien C. Vantourout, Allan J. B. Watson
Publikováno v:
European Journal of Organic Chemistry. 2022
Funding: Engineering and Physical Sciences Research Council; University of St Andrews; Leverhulme Trust (GrantNumber(s): RF-2022-014). We report the development of a method for the direct Chan–Lam coupling of arylboronic acid N-methyliminodiacetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3817988ef8b6969bcb74e17957de3430
https://doi.org/10.1002/ejoc.202200993
https://doi.org/10.1002/ejoc.202200993
Publikováno v:
Encyclopedia of Reagents for Organic Synthesis. :1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fcc82ae4eec0911ef9227ad33403c4e
https://doi.org/10.1002/047084289x.rn00744.pub2
https://doi.org/10.1002/047084289x.rn00744.pub2
Autor:
Glenn A. Burley, Harry P. de Koning, John Forsyth Russell Robertson, Katherine Louise Jones, Marzuq A. Ungogo, Leandro Lemgruber, Allan J. B. Watson, Mustafa M. Aldfer, Fergus S. McWhinnie, Bela E. Bode
Publikováno v:
ChemMedChem. 16:3396-3401
J.R. and G.A.B. thank GlaxoSmithKline (GSK) and the Engineering and Physical Sciences Research Council (EPSRC) for an industrial CASE studentship. MMA is supported by a studentship from the government of Libya, and MAU by a studentship from the Petro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e92e8938405e7c0fa01d89f09d9c21
https://doi.org/10.1002/cmdc.202100509
https://doi.org/10.1002/cmdc.202100509
Autor:
David L. Cain, Niall A. Anderson, David B. Cordes, Alexandra M. Z. Slawin, Allan J. B. Watson
Funding: D.L.C. thanks EPSRC and GSK for a Ph.D. studentship. A concise strategy for the total synthesis of several Aspidosperma alkaloids is reported. A Suzuki–Miyaura cross-coupling provides access to a 2-vinyl indole that undergoes a Diels–Ald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e0b32c9e91e6b66a0e30c4f0f8dfe0
https://hdl.handle.net/10023/26256
https://hdl.handle.net/10023/26256
E.M.I and A.J.B.W. thank Syngenta and EPSRC for an iCASE PhD studentship. Global food security is one of the foremost challenges of our time and requires a multifaceted solution. Crop protection strategies are an essential part of this response; howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800978d6ce90ef7ba9701ced160c8dbf
https://hdl.handle.net/10023/26198
https://hdl.handle.net/10023/26198
Autor:
Nicola L. Bell, Thomas M. McGuire, Sonia Chabbra, Alexandra M. Z. Slawin, James W. B. Fyfe, David B. Cordes, Allan J. B. Watson, Chao Xu, Julien C. Vantourout, Bela E. Bode, Jeremy Brals
Publikováno v:
Angewandte Chemie International Edition. 60:7935-7940
Funding: Leverhulme Trust (Grant Number(s): RPG-2015-308), Leverhulme Trust (Grant Number(s): RPG-2018-362), Engineering and Physical Sciences Research Council (Grant Number(s): EP/R025754/1). Metal‐catalyzed C–N cross‐coupling generally forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdf5dde6c67a9b2e41b4bb09de2ddfd
https://doi.org/10.1002/anie.202016811
https://doi.org/10.1002/anie.202016811
Autor:
Mark R. Harpel, Ghotas Evindar, Shenaz Bunally, David G. Washburn, Steve Wilson, Joanne Prendergast, Scott G. Summerfield, Katrina Rivera, Chun-wa Chung, Julien C. Vantourout, Steven R. Skinner, Neil Young, Xiaopeng Bai, Christopher C. Arico-Muendel, Albert Isidro-Llobet, Rakesh Lad, William Traylen, Graham L. Simpson, Josephine Yuen, Letian Kuai, Paul Scott-Stevens, Kim Lambert, Sandeep Pal, Saul Needle, Andrew M. Mason, Michael J Hobbs, Emma V. Edgar, Richard Snell, Lara S. Kallander, Eric X Shi, Lisa M. Shewchuk, Dennis A. Holt, Allan J. B. Watson
Publikováno v:
Bioconjugate Chemistry. 32:279-289
Reducing the required frequence of drug dosing can improve the adherence of patients to chronic treatments. Hence, drugs with longer in vivo half-lives are highly desirable. One of the most promising approaches to extend the in vivo half-life of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b213e0b311b3358e0c31efff0d5b13f
https://doi.org/10.1021/acs.bioconjchem.0c00662
https://doi.org/10.1021/acs.bioconjchem.0c00662