Zobrazeno 1 - 10
of 35
pro vyhledávání: '"J B Lefkowith"'
Publikováno v:
Scandinavian Journal of Rheumatology. 30:11-18
Objective: A clinical trial was conducted in 600 patients with OA of the knee to test the hypothesis that the specific COX-2 inhibitor, celecoxib, has equivalent efficacy and a superior tolerability/safety profile when compared to diclofenac, the cur
Publikováno v:
The Journal of Immunology. 158:3917-3924
Using anti-glomerular basement membrane nephritis in rats, we investigated the mechanisms underlying in situ chemokine expression and the in vivo function of these cytokines during the acute phase of this model. We observed that CXC chemokine express
Publikováno v:
The Journal of Immunology. 157:1297-1305
We recently produced a panel of seven glomerular-binding mAbs from a nephritic MRL-lpr mouse that bind to histones/nucleosomes (group I) or DNA (group II) adherent to glomerular basement membrane. To elucidate the molecular basis of their binding and
Publikováno v:
The Journal of Immunology. 155:2258-2268
We recently identified that the glomerular binding activity in MRL/lpr serum consists of Abs reactive with DNA/histone adherent to glomerular basement membrane (GBM) via type IV collagen. These studies suggest the presence of multiple nephritogenic a
Publikováno v:
The Journal of Immunology. 154:2424-2433
To clarify the pathogenesis of lupus nephritis, we developed an assay that defines a glomerular binding activity (GBA) in both murine and human lupus sera highly correlated with nephritis. In the current study, we used a cross-adsorption strategy to
Publikováno v:
Clinical and Experimental Immunology. 93:418-423
SUMMARYThe pathogenesis of lupus nephritis is felt to be mediated by anti-DNA antibodies. However, the anti-DNA response and renal disease do not entirely correspond. We recently developed a new assay which detects immune elements based on their abil
Publikováno v:
The Journal of Immunology. 149:1729-1735
Phospholipase activation is an important element in cellular signal transduction. In our study we investigated the role and regulation of phospholipase activation during human monocyte adherence and spreading. In human monocytes, phospholipase inhibi
Publikováno v:
The Journal of Immunology. 145:1523-1529
Dietary polyunsaturated fatty acid modulation has been used as an anti-inflammatory strategy in experimental models of disease as well as in clinical trials. To elucidate the mechanisms underlying the anti-inflammatory effects of manipulating dietary
Publikováno v:
The Journal of Immunology. 145:1238-1245
Injection of nephrotoxic serum into rats results in glomerular inflammation and proteinuria. Rats placed on an essential fatty acid (EFA)-deficient diet are protected from the glomerular macrophage infiltration and the ensuing proteinuria. To account
Publikováno v:
Scandinavian journal of rheumatology. 30(1)
A clinical trial was conducted in 600 patients with OA of the knee to test the hypothesis that the specific COX-2 inhibitor, celecoxib, has equivalent efficacy and a superior tolerability/safety profile when compared to diclofenac, the current worldw