Zobrazeno 1 - 10
of 36
pro vyhledávání: '"J B Imboden"'
Publikováno v:
The Journal of Immunology. 158:4688-4695
Perturbation of several distinct T cell molecules, including the CD3/TCR complex, CD7, and CD28, activates phosphatidylinositol 3-kinase (PI3-K), but a clear consensus on the role of PI3-K in T cell activation has yet to emerge. We report here that C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79518884173a4bbca5f6c148d554ac88
https://doi.org/10.4049/jimmunol.158.10.4688
https://doi.org/10.4049/jimmunol.158.10.4688
Publikováno v:
The Journal of Immunology. 151:3646-3653
To examine the role of CD45 in NK cell activation, we isolated three mutants and one variant of a rat NK cell line, RNK-16. Each of these lacked cell-surface expression of CD45 and did not have detectable transcripts for CD45 on Northern blot analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9217552c47c42fcb4d744fa74a684d8
https://doi.org/10.4049/jimmunol.151.7.3646
https://doi.org/10.4049/jimmunol.151.7.3646
Publikováno v:
The Journal of Immunology. 146:3703-3708
Ligand-induced activation of T cells results in stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC). A structurally diverse family of PI-PLC isoforms has recently been defined, and more than one isoform is frequently coexpressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d4d5b3b36db999f53f00c15594ef22
https://doi.org/10.4049/jimmunol.146.11.3703
https://doi.org/10.4049/jimmunol.146.11.3703
Publikováno v:
The Journal of Immunology. 146:1577-1583
In lymphocytes, CD45 regulates the increase in cytoplasmic calcium concentration that occurs after receptor cross-linking. Here we show that T cell receptor complex (CD3/Ti)-mediated inositol phosphate production was inhibited by CD45 ligation in Jur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e6f7911855ea0e7e6c22585593f8ac
https://doi.org/10.4049/jimmunol.146.5.1577
https://doi.org/10.4049/jimmunol.146.5.1577
Publikováno v:
The Journal of Immunology. 145:2862-2872
The predominant T lymphocytes that accumulate in the peripheral lymphoid tissues of mice homozygous for the lpr gene bear the phenotype CD3+CD4-CD8-. By certain functional criteria these cells would appear to have impaired CD3-mediated signal transdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baaa7347fdbbf57286038016c6df0434
https://doi.org/10.4049/jimmunol.145.9.2862
https://doi.org/10.4049/jimmunol.145.9.2862
Autor:
J A, Ledbetter, J B, Imboden, G L, Schieven, L S, Grosmaire, P S, Rabinovitch, T, Lindsten, C B, Thompson, C H, June
Publikováno v:
Blood. 75:1531-1539
The CD28 homodimer is thought to function as a signal transducing receptor during activation of T cells. Evidence is presented that the degree of aggregation of CD28 on the cell surface regulates two distinct CD28-associated signals. Binding of bival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c105ed4801c15305e722fa92c005ee41
https://doi.org/10.1182/blood.v75.7.1531.bloodjournal7571531
https://doi.org/10.1182/blood.v75.7.1531.bloodjournal7571531
Autor:
G M Bell, J B Imboden
Publikováno v:
The Journal of Immunology. 155:2805-2807
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10bb34260cebd8aafbcfd821a72a2a3e
https://doi.org/10.4049/jimmunol.155.6.2805
https://doi.org/10.4049/jimmunol.155.6.2805
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(10)
The accessory molecule CD28 delivers a costimulus that acts in concert with TCR signals to promote T cell activation. Activation of Jun-N-terminal kinases (JNK) requires simultaneous stimulation of the TCR and CD28 and, therefore, likely plays an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcbac6baf0c3dbfbc3d24df7eea988f9
https://pubmed.ncbi.nlm.nih.gov/9820510
https://pubmed.ncbi.nlm.nih.gov/9820510
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(10)
Perturbation of several distinct T cell molecules, including the CD3/TCR complex, CD7, and CD28, activates phosphatidylinositol 3-kinase (PI3-K), but a clear consensus on the role of PI3-K in T cell activation has yet to emerge. We report here that C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66834f2b046b35e77a387abcb8dd061b
https://pubmed.ncbi.nlm.nih.gov/9144481
https://pubmed.ncbi.nlm.nih.gov/9144481