Zobrazeno 1 - 10
of 477
pro vyhledávání: '"J B Brown"'
Autor:
J B Brown, Noriomi Matsumura, Masaki Mandai, Ken Yamaguchi, Shiro Takamatsu, Junzo Hamanishi, Koji Yamanoi, Kosuke Murakami, Osamu Gotoh, Seiichi Mori
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background In cancer therapy, higher-resolution tumor-agnostic biomarkers that predict response to immune checkpoint inhibitor (ICI) therapy are needed. Mutation signatures reflect underlying oncogenic processes that can affect tumor immunogenicity,
Externí odkaz:
https://doaj.org/article/dd13e3f6cbfa447192a9fc8517aba62c
Autor:
Yuki Makino, Yuki Kamiyama, J. B. Brown, Toshiya Tanaka, Ryusuke Murakami, Yuki Teramoto, Takayuki Goto, Shusuke Akamatsu, Naoki Terada, Takahiro Inoue, Tatsuhiko Kodama, Osamu Ogawa, Takashi Kobayashi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Through comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castrati
Externí odkaz:
https://doaj.org/article/1616ee52299048a1a15f3ff943dad8e7
Autor:
Ryusuke Murakami, Junzo Hamanishi, J. B. Brown, Kaoru Abiko, Koji Yamanoi, Mana Taki, Yuko Hosoe, Ken Yamaguchi, Tsukasa Baba, Noriomi Matsumura, Ikuo Konishi, Masaki Mandai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Based on our previous phase II clinical trial of anti-programmed death-1 (PD-1) antibody nivolumab for platinum-resistant ovarian cancer (n = 19, UMIN000005714), we aimed to identify the biomarkers predictive of response. Tumor gene expressi
Externí odkaz:
https://doaj.org/article/2172fc8b2d534ff6b34b0f655aab8608
Autor:
Asuka Okunomiya, Akihito Horie, Hirohiko Tani, Yukiyasu Sato, Shiro Takamatsu, J. B. Brown, Miki Sugimoto, Junzo Hamanishi, Eiji Kondoh, Noriomi Matsumura, Masaki Mandai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The in vitro growth (IVG) of human follicles is a potential fertility option for women for whom cryopreserved ovarian tissues cannot be transplanted due to the risk of cancer cell reintroduction; however, there is currently no established me
Externí odkaz:
https://doaj.org/article/203fc67e70f04c57a9cec91aeea62a71
Autor:
Michelle A. Williams, Alena Aliashkevich, Elizaveta Krol, Erkin Kuru, Jacob M. Bouchier, Jonathan Rittichier, Yves V. Brun, Michael S. VanNieuwenhze, Anke Becker, Felipe Cava, Pamela J. B. Brown
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
While the structure and function of the bacterial cell wall are well conserved, the mechanisms responsible for cell wall biosynthesis during elongation are variable. It is increasingly clear that rod-shaped bacteria use a diverse array of growth stra
Externí odkaz:
https://doaj.org/article/ae7cba1b5fb245f3bb0db0fd40e1c380
Autor:
Wanda M. Figueroa-Cuilan, Amelia M. Randich, Caroline M. Dunn, Gustavo Santiago-Collazo, Andrew Yowell, Pamela J. B. Brown
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
LytM-domain containing proteins are LAS peptidases (lysostaphin-type enzymes, D-Ala-D-Ala metallopeptidases, and sonic hedgehog) and are known to play diverse roles throughout the bacterial cell cycle through direct or indirect hydrolysis of the bact
Externí odkaz:
https://doaj.org/article/22b1c690d93641188bf5f640207d0e98
Publikováno v:
Journal of Bacteriology. 205
Agrobacterium tumefaciens incites the formation of readily visible macroscopic structures known as crown galls on plant tissues that it infects. Records from biologists as early as the 17th century noted these unusual plant growths and began examinin
Autor:
Ashleigh J. Burke, Thomas M. Lister, James R. Marshall, Murray J. B. Brown, Richard Lloyd, Anthony P. Green, Nicholas J. Turner
Publikováno v:
ChemCatChem.
Autor:
Freideriki Michailidou, Tomas Lebl, Alexandra M. Z. Slawin, Sunil Vishnuprasadji Sharma, Murray J. B. Brown, Rebecca Jane Miriam Goss
Publikováno v:
Molecules, Vol 25, Iss 23, p 5513 (2020)
Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2′,3′-dideoxy-2′,3′-difluoro nucleosides, ha
Externí odkaz:
https://doaj.org/article/cdcccc80b6af495089b9188addd0cb9a
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Agrobacterium tumefaciens is a plant pathogen that causes crown gall disease, leading to the damage of agriculturally-important crops. As part of an effort to discover new phages that can potentially be used as biocontrol agents to prevent crown gall
Externí odkaz:
https://doaj.org/article/0fbb3592ecdc459daa89637d9872b14b