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Burkitt's lymphoma: a pericardial presentation

Autor: B. Duval-Arnould, T. C. Mercado, J. D. Cotelingam, S. J. Graham, J. B. Trepel

Publikováno v: Cytopathology. 1:239-242

Described herein is a case of childhood Burkitt's lymphoma initially presenting as a pericardial effusion. A cytological diagnosis was made from a Wright's-Giemsa stained cytospin preparation. Supporting diagnostic evidence was provided by immunologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962205c5127a59daac96a238568432f8
https://doi.org/10.1111/j.1365-2303.1990.tb00353.x

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MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells

Autor: B I, Lee, S H, Park, J W, Kim, E A, Sausville, H T, Kim, O, Nakanishi, J B, Trepel, S J, Kim

Publikováno v: Cancer research. 61(3)

Transcriptional repression of the transforming growth factor (TGF)-1P type II receptor (TPRII) gene appears to be a major mechanism to inactivate TGF-beta responsiveness in many human cancers. Because histone acetylation/deacetylation plays a role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de27aef873ea4c8c9fd655dcc755696d
https://pubmed.ncbi.nlm.nih.gov/11221885

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Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

Autor: S G Hwang, W G An, J B Trepel, M V Blagosklonny

Publikováno v: Leukemia. 14(7)

Inhibitors of proteases are currently emerging as a potential anti-cancer modality. Nonselective protease inhibitors are cytotoxic to leukemia and cancer cell lines and we found that this cytotoxicity is correlated with their potency as inhibitors of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfd3b0dede8735535840303a3cab03d
https://pubmed.ncbi.nlm.nih.gov/10914553

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Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines

Autor: H K, Yang, F M, Scott, J B, Trepel, J F, Battey, B E, Johnson, M J, Kelley

Publikováno v: Lung cancer (Amsterdam, Netherlands). 21(3)

The murine anti-bombesin monoclonal antibody, 2A11, has been demonstrated to inhibit growth of some small-cell lung cancer (SCLC) cells in nude mice xenografts and in a clinical trial. To determine if the expression of bombesin-like peptides (BLP) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69009457224f067ce054de58a4c4ff82
https://pubmed.ncbi.nlm.nih.gov/9857994

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Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

Autor: S J, Lee, M J, Ha, J, Lee, P, Nguyen, Y H, Choi, F, Pirnia, W K, Kang, X F, Wang, S J, Kim, J B, Trepel

Publikováno v: The Journal of biological chemistry. 273(17)

Progression through the cell cycle is controlled by the induction of cyclins and the activation of cognate cyclin-dependent kinases. The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor lovastatin induces growth arrest and cell dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2bfe0a46fa35ed9ef33d3a1a13fdd37
https://pubmed.ncbi.nlm.nih.gov/9553123

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Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3

Autor: M M, Borner, C E, Myers, O, Sartor, Y, Sei, T, Toko, J B, Trepel, E, Schneider

Publikováno v: Cancer research. 55(10)

The propensity of a cell to undergo apoptosis has been proposed to be a determinant for chemotherapy sensitivity that is not directly dependent on specific drug-target interactions. Androgen-independent prostate cancer is typically refractory to cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb190713cfa75ddb37e30a67d5a04fbd
https://pubmed.ncbi.nlm.nih.gov/7743512

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A phase I study of TRC105 (anti-CD105 monoclonal antibody) in metastatic castration-resistant prostate cancer (mCRPC)

Autor: D. Adelberg, A. B. Apolo, R. A. Madan, J. L. Gulley, A. Pierpoint, D. R. Kohler, J. B. Trepel, S. M. Steinberg, W. D. Figg, W. L. Dahut

Publikováno v: Journal of Clinical Oncology. 29:171-171

171 Background: TRC105 is a human/murine chimeric IgG1 monoclonal antibody to CD105 (endoglin) that inhibits angiogenesis and tumor growth through inhibition of endothelial cell (EC) proliferation, antibody-dependent cellular cytotoxicity and inducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::547ae24a4af8ea86dd485b236fb6ed3d
https://doi.org/10.1200/jco.2011.29.7_suppl.171

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