Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

Autor: Alan Percy, Cathy Wood-Siverio, Oksana Suchowersky, Claudia Testa, Yvette Bordelon, Kevin M. Biglan, Francis O. Walker, David P. Richman, Rustom Sethna, Eric Siemers, Shirley Eberly, Marie Saint-Hilaire, Alicia Brocht, Madaline B. Harrison, Richard H. Myers, Carlos Singer, Karen Blindauer, Rajeev Ananda Kumar, Jody Goldstein, Diana Rosas, Anne Young, Charles H. Adler, Kimberly Quaid, James F. Gusella, Carolyn Gray, Penelope Hogarth, James B. Caress, J. B. Penney, Kelvin L. Chou, Teresa Tempkin, Christopher Ross, Jody Corey-Bloom, Brad Racette, Victoria Hunt, William Weiner, Thomas D. Bird, J. Decolongon, Greg Suter, Eric Molho, Megan Romer, Blair Leavitt, Mary Lou Klimek, Hillary Lipe, Peter Como, Dawn Radtke, Constance Nickerson, Roger L. Albin, Karen Marder, Marcy E. MacDonald, Sandra Kostyk, Christine Weaver, David Oakes, William Mallonee, Amy Duffy, Tatiana Foroud, Marguerite Wieler, Clifford W. Shults, Sarah Furtado, Julie C. Stout, William C. Johnson, Timothy Greenamyre, Ira Shoulson, Carol Moskowitz, J.S. Paulsen, Karl Kieburtz, Lauren Seeberger, Douglas Hobson, Scott R. Bundlie, Steven M. Hersch, Leon S. Dure, Arthur Watts, Vicki L. Wheelock, Donald S. Higgins, Lorne A. Clarke, Stanley Fahn, Nestor Galvez-Jimenez, Andrew Feigin, Lynn A. Raymond, Joseph Jankovic, Sylvain Chouinard, Caroline M. Tanner, Melissa Wesson, Barbara Shannon, Marie Cox, Cynthia L. Comella, John N. Caviness, Guerry M. Peavy, Adam Rosenblatt, Robert A. Hauser, Carol Zimmerman, Christine Hunter, Christine O'Neill, Juan Sanchez-Ramos, Corrine Baic, Peter Novak, Sharon Evans, Hongwei Zhao, Stewart A. Factor, W.R. Wayne Martin, Candace Cotto, Richard Dubinsky, David D. Song, M. Aileen Shinaman, Susan B. Perlman, Joel S. Perlmutter, Ali Samii, Elise Kayson, Mark Guttman, Frederick J. Marshall, Kathleen L. Shannon, M. Nance

Publikováno v: JAMA neurology. 73(1)

Identifying measures that are associated with the cytosine-adenine-guanine (CAG) expansion in individuals before diagnosis of Huntington disease (HD) has implications for designing clinical trials.To identify the earliest features associated with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa05623ec4df08194f06e5de9f4bc97
https://pubmed.ncbi.nlm.nih.gov/26569098

A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease

Autor: Lawrence Elmer, McGuire D, Janis M. Miyasaki, Pierre N. Tariot, Cynthia L. Comella, Rajesh Pahwa, S. Schuman, Margaret C. Lannon, James W. Tetrud, Wiener W, Christopher Cox, Oksana Suchowersky, Wratni E, Lucia M. Blasucci, Chase T, Greenamyre Jt, Karen Hodgeman, Deleo A, Michael P. McDermott, Carrion A, Panniset M, Paula D. Ryan, Robert A. Hauser, Johnston L, Bateman-Rodriguez D, Amy Colcher, Baker D, Mistura K, Andrew Siderowf, W.R. Wayne Martin, Peggy Gray, Constance Orme, Jeffrey Friedlander, Charles H. Adler, Dilllon S, Stanley Fahn, Eric Siemers, David Grimes, Lauren Seeberger, M. Brewer, Colleen Dingmann, Frey J, Holdich T, Cooper J, Mark Stacy, Stewart A. Factor, Daniel Tarsy, Kennedy L, McCree L, Mary Lloyd, J. B. Penney, Lisa Gauger, Pantella C, Arthur Watts, Kenneth Marek, John P. Hammerstad, Matthews M, Kimberly Janko, Diane Brown, Denni Day, McDermott J, Sulimowicz K, Ruzicka D, Marsha Tennis, Bardram K, Joann Belden, Madaline B. Harrison, Blair Ford, Davies R, Mark F. Lew, Alderfer, Jennifer Mazurkiewicz, Elise Kayson, Broshjeit S, Rexo L, Andrew Feigin, Craun Am, Cha Jh, C. Stone, Stephanie Newman, Nirupama Laroia, Jean Hall, Ira Shoulson, Peter A LeWitt, Read B, Robert L. Rodnitzky, Danna Jennings, Judith Dobson, Lang A, Florack M, Nobel R, Steven R. Schwid, Leventhal C, A. L. Lafontaine, Nancy Pearson, Lawrence N. Shulman, Rothenburgh K, Rost E, Locke B, Cindy Casaceli

Publikováno v: Neurology. 56:455-462

Background Preclinical studies suggest that glutamate antagonists help ameliorate motor fluctuations in patients with PD treated with levodopa. Methods In a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d568a8ad50ad99173f553a65cfb0dde5
https://doi.org/10.1212/wnl.56.4.455

Twelfth annual symposia on etiology, pathogenesis, and treatment of parkinson's disease and etiology, pathogenesis, and treatment of Huntington's disease

Autor: S. B. Wilkinson, D. S. Sax, K. Kompoliti, C. Eberly, L. M. Shulman, S. A. Factor, K. K. Zakzanis, M. Brewer, C. DeCarti, M. Takanashi, S. A. Alsdorf, K. Frey, M. R. Kilbourn, C. Comella, G. P. Bates, W. M. Chung, A. S. Menon, C. B. Moskowitz, R. Schwartz, J. M. Bertoni, Tatiana Foroud, John Seibyl, A. Minagar, J. Kieltyka, P. M. Conneally, R. A. Hauser, H. Ellgring, W. J. Weiner, S. W. Davies, R. Pahwa, L. Quinn, M. Freedman, R. Innis, A. Willing, E. Kaplan, N. I. Bohnen, Paul J. Tuite, T. Yanagihara, J. H J Cha, J. Hubble, F. Cardoza, G. Rouleau, L. Mangiarini, E. Aylward, M. Guttman, G. Ulm, A. B. Young, B. Pfeiffer, A. Malik, Juan Sanchez-Ramos, A. S. Frey, J. B. Penney, A. I. Troster, K. Abe, G. Bates, K. Francis, K. E. Lyons, Roger L. Albin, W. C. Koller, C. Kornetsky, M. Seeland, L. Leach, K. A. Frey, M. Baehr, R. A. Koeppe, Karl Kieburtz, David Oakes, G. W. Paulson, E. R. Siemers, Joanne Wojcieszek, L. W. Elmer, T. A. Zesiewicz, Kenneth Marek, D. Strickland, Mark Stacy

Publikováno v: Movement Disorders. 13:858-863

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ec5432e57559fcb153af697083b122b
https://doi.org/10.1002/mds.870130522

Expression of N-Methyl-D-Aspartate receptor subunit mRNA in the human brain: Mesencephalic dopaminergic neurons

Autor: Clemens R. Scherzer, T J Counihan, G B Landwehrmeyer, Gonul Velicelebi, J. B. Penney, Christoph M. Kosinski, David G. Standaert, Lorrie P. Daggett, Anne B. Young

Publikováno v: The Journal of Comparative Neurology. 390:91-101

Evidence is accumulating that glutamate-mediated excitotoxicity plays an important role in neuronal degeneration in Parkinson's disease (PD). In addition, alterations in excitatory amino acid neurotransmission in the basal ganglia contribute to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ae3867fd793773c68b92d037196eadf
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<91::aid-cne8>3.0.co

Differential expression of kainate receptors in the basal ganglia of the developing and adult rat brain

Autor: Claudia M. Testa, David G. Standaert, Anne B. Young, J. B. Penney, Ullrich Wüllner

Publikováno v: Brain Research. 768:215-223

Glutamate is the principal excitatory transmitter of the mammalian brain and plays a particularly important role in the physiology of the basal ganglia structures responsible for movement regulation. Using in situ hybridization with oligonucleotide p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5427022ebe6a69a4018bf61fb7f449
https://doi.org/10.1016/s0006-8993(97)00645-8