Výsledky vyhledávání - "J B, Houston"

COVID-19 Communication Ecology: Visualizing Communication Resource Connections During a Public Health Emergency Using Network Analysis

Autor: Murali K. Mantrala, J. B. Houston, Eunjin (Anna) Kim, Esther Thorson

Publikováno v: The American Behavioral Scientist

The COVID-19 outbreak began in December 2019 and soon became a global pandemic, resulting in major public health consequences for countries across the world. As the COVID-19 outbreak evolved, individuals were challenged to understand the risk of COVI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0822f5c12bffd2299ab44e2d8a107344
http://europepmc.org/articles/PMC7868348

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The metabolism of the 5HT3antagonists ondansetron, alosetron and GR87442 I: A comparison ofin vitroandin vivometabolism andin vitroenzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes

Autor: J B Houston, G. I. Somers, A. J. Harris, M. K. Bayliss

Publikováno v: Xenobiotica. 37:832-854

The metabolism of the structurally related 5HT3 antagonists ondansetron, alosetron and GR87442 in the rat, dog and human was determined in hepatocytes, liver microsomes and human recombinant microsomes. The profiles of phase I metabolites were simila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6c06921759f42f387c96716f8ffd32e
https://doi.org/10.1080/00498250701485575

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Microsomal prediction ofin vivoclearance and associated interindividual variability of six benzodiazepines in humans

Autor: J B Houston, David Carlile, Aleksandra Galetin, David Hallifax, Kiyomi Ito, Andrew Tindall, H.C Rawden

Publikováno v: Xenobiotica. 35:603-625

The intrinsic clearances (CLint) of midazolam, triazolam, diazepam, nordiazepam, flunitrazepam and alprazolam were determined from two liver banks (n=21) by formation kinetics of ten metabolites. A literature-collated database of in vivo CLint values

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1de7c5e1f41d24a3e3b91eb07b0bcec
https://doi.org/10.1080/00498250500162870

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Impact of end-product inhibition on the determination ofin vitrometabolic clearance

Autor: Hannah M. Jones, G. Nicholls, J B Houston

Publikováno v: Xenobiotica. 35:439-454

End-product inhibition was explored as a mechanism for the lower clearance determination obtained from microsomes compared with hepatocytes. Triazolam, diazepam and phenytoin microsomal substrate depletion was reduced by 23, 34 and 39%, respectively,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707458dcf7520247aa0674cb1f88eb42
https://doi.org/10.1080/00498250500136619

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Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

Autor: J B Houston, M. F. Abd-Ellah, J. Andrews, T. Friedberg, K. E. Kenworthy, N. L. Randolph, D. J. Carlile

Publikováno v: Xenobiotica. 32:937-947

1. The aim was to compare the metabolic activity of human CYP3A4 expressed in bacteria (E. coli), yeast (S. cerevisiae) and human lymphoblastoid cells (hBl), with the native CYP3A4 activity observed in a panel of human livers. 2. Three CYP3A4 substra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c40c5121fb6653a146332be02a6bfa
https://doi.org/10.1080/00498250210163289

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