Zobrazeno 1 - 10
of 39
pro vyhledávání: '"J B, Hibbs"'
Publikováno v:
Clinical and Experimental Immunology. 97:83-86
SUMMARYThe discovery that humans produce nitric oxide and that this molecule plays an important role in cell communication, host resistance to infection, and perhaps in host defence to neoplastic disease, has created much interest in further research
Publikováno v:
The Journal of Immunology. 151:907-915
In vitro experiments suggest that cytokine induced nitric oxide (NO) synthesis from L-arginine is a major effector mechanism against prokaryotic and eukaryotic intracellular pathogens. N omega monomethyl L-arginine (MLA), an active site inhibitor of
Publikováno v:
The Journal of Immunology. 146:1294-1302
Murine macrophage oxidation of L-arginine guanidino nitrogen to nitrite/nitrate yields an intermediate effector, possibly nitric oxide, with antimicrobial activity. Total body nitrogen oxidation metabolism (NOM) was measured in vivo by determining th
Publikováno v:
The Journal of Immunology. 144:2725-2729
Recent studies show the importance of a single amino acid, L-arginine, as a necessary substrate for activated macrophage-mediated cytotoxic activity for tumor target cells and microbiostatic function for Cryptococcus neoformans. The present studies w
Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
Publikováno v:
Methods in enzymology. 268
Autor:
J C, Drapier, J B, Hibbs
Publikováno v:
Methods in enzymology. 269
Autor:
C Y, Yim, J R, McGregor, O D, Kwon, N R, Bastian, M, Rees, M, Mori, J B, Hibbs, W E, Samlowski
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(9)
IL-2 therapy is a potent inductive stimulus for nitric oxide (NO.) synthesis in mice and humans. It is not yet clear whether NO. can contribute to IL-2-induced therapeutic responses. The murine skin cancer Meth A is relatively resistant to lymphokine
Publikováno v:
Transplantation proceedings. 27(2)
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 152(12)
IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates. Glutathione, the major intracellular reductant, may become rate limiting to cytotoxic lymphocyte activation and proliferation under these circumstances. N
Publikováno v:
The Journal of biological chemistry. 269(7)
The cell-mediated immune response to syngeneic tumors activates the cytokine-inducible nitric oxide synthase. We observed that syngeneic murine tumors exhibited EPR signals related to iron-nitrosyl complex formation. Three different EPR active iron-n