Zobrazeno 1 - 10
of 35
pro vyhledávání: '"J B, Gibbs"'
Publikováno v:
Health Physics. 83:S36-S44
Health care laser systems offer general laser hazards and additional specific concerns unique to the clinical environment. A formal laser hazard evaluation procedure provides an efficient mechanism for identifying potential laser safety hazards. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae630923b20960b0ba98dc19e26654f
https://doi.org/10.1097/00004032-200208001-00012
https://doi.org/10.1097/00004032-200208001-00012
Autor:
C. A. Omer, J. B. Gibbs
Publikováno v:
Molecular Microbiology. 11:219-225
Summary Modrfication of proteins at C-terminal cysteine residue(s) by the isoprenoids farnesyl (C15) and geranylgeranyl (C20) is essential for the biological function of a number of eukaryotic proteins including fungal mating factors and the small, G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44f1051051fd867ca33066d0e3f3a49
https://doi.org/10.1111/j.1365-2958.1994.tb00302.x
https://doi.org/10.1111/j.1365-2958.1994.tb00302.x
Publikováno v:
Journal of Biological Chemistry. 268:19935-19938
In Xenopus oocytes, mitogen-activated protein (MAP) kinase can be activated by progesterone treatment or by microinjection of cyclin A, both of which lead to activation of the cdc2 protein kinase. The tyrosine kinase pp60v-src has previously been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b56fdfec18afc508bfd15d792f5bfd1f
https://doi.org/10.1016/s0021-9258(20)80676-0
https://doi.org/10.1016/s0021-9258(20)80676-0
Publikováno v:
Journal of Biological Chemistry. 267:11612-11618
Ras GTPase-activating protein (GAP) has been implicated in mitogenic signal transduction downstream of oncogenic and receptor tyrosine kinases. Previous studies have suggested that GAP is phosphorylated by oncogenic viral Src (v-Src) and that GAP is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9593e025a4f116360877a25aa31c22c4
https://doi.org/10.1016/s0021-9258(19)49955-9
https://doi.org/10.1016/s0021-9258(19)49955-9
Publikováno v:
Molecular and Cellular Biology. 11:945-953
GTPase-activating protein (GAP) is a cytosolic protein that stimulates the rate of hydrolysis of GTP (GTP to GDP) bound to normal p21ras, but does not catalyze the hydrolysis of GTP bound to oncogenic, activated forms of the ras protein. Transformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd78d9025dd19fc62d7aae593dbbab1
https://doi.org/10.1128/mcb.11.2.945-953.1991
https://doi.org/10.1128/mcb.11.2.945-953.1991
Publikováno v:
Molecular and Cellular Biology. 10:1689-1696
Transforming Harvey (Ha) ras oncogene products accelerated the time course of Xenopus oocyte maturation induced by insulin, insulinlike growth factor 1, or progesterone. The transforming constructs, [Val-12]Ha p21 and [Val-12, Thr-59]Ha p21, displaye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e2aca8123c55e62dce5820815050de
https://doi.org/10.1128/mcb.10.4.1689
https://doi.org/10.1128/mcb.10.4.1689
Autor:
Neville J. Anthony, Theresa M. Williams, Joseph P. Davide, Nancy E. Kohl, Ian M. Bell, Samuel L. Graham, H. E. Huber, J. B. Gibbs, George D. Hartman, Kenneth S. Koblan, C. A. Buser, D. C. Heimbrook, S J deSolms, Christopher J. Dinsmore, Robert B. Lobell
Publikováno v:
Anticancer Agents ISBN: 9780841237452
Anticancer Agents: Frontiers in Cancer Chemotherapy
Anticancer Agents: Frontiers in Cancer Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fec5534feae29f7a850e8e10d2903e2e
https://doi.org/10.1021/bk-2001-0796.ch011
https://doi.org/10.1021/bk-2001-0796.ch011
Autor:
E, Cohen-Jonathan, R J, Muschel, W, Gillies McKenna, S M, Evans, G, Cerniglia, R, Mick, D, Kusewitt, S M, Sebti, A D, Hamilton, A, Oliff, N, Kohl, J B, Gibbs, E J, Bernhard
Publikováno v:
Radiation research. 154(2)
Successful radiosensitization requires that tumor cells become more radiosensitive without causing an equivalent reduction in the survival of cells of the surrounding normal tissues. Since tumor cell radiosensitivity can be influenced by RAS oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e5d95574a27208373ea5105d4620f6f
https://pubmed.ncbi.nlm.nih.gov/10931682
https://pubmed.ncbi.nlm.nih.gov/10931682
Autor:
C A, Omer, Z, Chen, R E, Diehl, M W, Conner, H Y, Chen, M E, Trumbauer, S, Gopal-Truter, G, Seeburger, H, Bhimnathwala, M T, Abrams, J P, Davide, M S, Ellis, J B, Gibbs, I, Greenberg, K S, Koblan, A M, Kral, D, Liu, R B, Lobell, P J, Miller, S D, Mosser, T J, O'Neill, E, Rands, M D, Schaber, E T, Senderak, A, Oliff, N E, Kohl
Publikováno v:
Cancer research. 60(10)
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme farnesyl:protein transferase (FPTase). Inhibitors of FPTase have therefore been developed as pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2912ec44ca2d1ecb77982ce053c4c10a
https://pubmed.ncbi.nlm.nih.gov/10825141
https://pubmed.ncbi.nlm.nih.gov/10825141
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
Publikováno v:
Blood. 94(7)
Oncogenic RAS alleles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state. Because post-translational processing of Ras by farnesyltransferase is essential for biologic function, inhibitors of this enzyme have been develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05b51fabaf4945cacd25e93337c54230
https://pubmed.ncbi.nlm.nih.gov/10498620
https://pubmed.ncbi.nlm.nih.gov/10498620