Zobrazeno 1 - 10
of 1 859
pro vyhledávání: '"J Ashton"'
Autor:
Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S. Mathotaarachchi, Jenna Stevenson, Firoza Z. Lussier, Andréa L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Females represent approximately 70% of the Alzheimer’s disease (AD) cases and the literature has proposed a connection between the decreased estrogen levels during menopause and an increased AD risk. Previous investigations have
Externí odkaz:
https://doaj.org/article/daf9534a01764ab599de980ae7f154aa
Autor:
Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M. Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Abstract Abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including Alzheimer’s disease (AD). In AD, this pathological change is reflec
Externí odkaz:
https://doaj.org/article/07ce566d50b649798807723349e5fe2c
Autor:
Anna Orduña Dolado, Erik Stomrud, Nicholas J. Ashton, Johanna Nilsson, Clara Quijano-Rubio, Alexander Jethwa, Wagner S. Brum, Ann Brinkmalm Westman, Henrik Zetterberg, Kaj Blennow, Shorena Janelidze, Oskar Hansson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Studies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhythm. However sustained sampling of large volumes of CSF with indwelling intrathecal catheters used in most of these studi
Externí odkaz:
https://doaj.org/article/f78a34bbdde94bdab236ffea02e7059b
Autor:
Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J. Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105413- (2024)
Summary: Background: Blood-based disease staging across the Alzheimer's disease (AD) continuum holds the promise to identify individuals that profit from disease-modifying therapies. We set out to identify Braak V+ (Braak V and/or VI) tau PET-positiv
Externí odkaz:
https://doaj.org/article/fb10423af32b4438978a55cda015eda3
Autor:
María Carmona-Iragui, Antoinette O'Connor, Jorge Llibre-Guerra, Patrick Lao, Nicholas J. Ashton, Juan Fortea, Raquel Sánchez-Valle
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105327- (2024)
Summary: Autosomal dominant Alzheimer's disease (ADAD) and Down syndrome (DS) constitute genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in understanding the biomarker changes and disease progression, notably in a
Externí odkaz:
https://doaj.org/article/8547582ebab9497f8370b64b43339c2f
Autor:
Miguel German Borda, George E. Barreto, Jonathan Patricio Baldera, Chiara de Lucia, Khadija Khalifa, Anne Katrine Bergland, Ilaria Pola, Felipe Botero-Rodríguez, Richard C. Siow, Miia Kivipelto, Henrik Zetterberg, Nicholas J. Ashton, Clive Ballard, Dag Aarsland
Publikováno v:
Experimental Gerontology, Vol 196, Iss , Pp 112569- (2024)
Background: Dementia poses a significant global health challenge. Anthocyanins neutralize free radicals, modulate signaling pathways, inhibit pro-inflammatory genes, and suppress cytokine production and may thus have positive cognitive effects in peo
Externí odkaz:
https://doaj.org/article/433537da3b7b4348a7e1e851f683962c
Autor:
Joseph Mugisha, Nicholas J Ashton, Claire J Steves, Racheal Alinaitwe, Josephine Prynn, Tunde Peto, Beatrice Kimono, Martin Prince
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background The prevalence of dementia in low- and middle-income countries is increasing, yet epidemiological data from African populations remain scarce. Crucial risk factors differ in Africa from more intensively studied global areas, including a hi
Externí odkaz:
https://doaj.org/article/db673c4e30424ea195c4fc5f0fc0715e
Autor:
Yi-Ting Wang, Nicholas J. Ashton, Stijn Servaes, Johanna Nilsson, Marcel S. Woo, Tharick A. Pascoal, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Firoza Lussier, Mira Chamoun, Serge Gauthier, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Andréa L. Benedet
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/892a82c42fb84ac6a6a98d8ee15c62b9
Autor:
Mikko Koivumäki, Laura Ekblad, Juan Lantero-Rodriguez, Nicholas J. Ashton, Thomas K. Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne, Anniina Snellman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tau tangles, and neurodegeneration in the brain parenchyma. Here, we aimed to (i) assess differences in blood and imaging
Externí odkaz:
https://doaj.org/article/ec950c17ae934bbbad1dedba707143df
Autor:
Augusto J. Mendes, Federica Ribaldi, Aurelien Lathuiliere, Nicholas J. Ashton, Henrik Zetterberg, Marc Abramowicz, Max Scheffler, Frédéric Assal, Valentina Garibotto, Kaj Blennow, Giovanni B. Frisoni
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Plasma biomarkers of Alzheimer’s disease (AD) pathology, neurodegeneration, and neuroinflammation are ideally suited for secondary prevention programs in self-sufficient persons at-risk of dementia. Plasma biomarkers have been s
Externí odkaz:
https://doaj.org/article/0d2fed2960a540e5986c1c8a6adf24c2