Zobrazeno 1 - 10
of 38
pro vyhledávání: '"J Anthony Wilson"'
Autor:
Sigrun M Gustafsdottir, Vebjorn Ljosa, Katherine L Sokolnicki, J Anthony Wilson, Deepika Walpita, Melissa M Kemp, Kathleen Petri Seiler, Hyman A Carrel, Todd R Golub, Stuart L Schreiber, Paul A Clemons, Anne E Carpenter, Alykhan F Shamji
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling assay that "paints the cell" with as man
Externí odkaz:
https://doaj.org/article/8c40507e5fdb43ab9bb993e3733562bc
Autor:
C. Suk-Yee Hon, Melissa A. Marton, Nicole E. Bodycombe, Sigrun M. Gustafsdottir, Vebjorn Ljosa, Paul A. Clemons, Vlado Dančík, Stuart L. Schreiber, Ellen Winchester, J. Anthony Wilson, Katherine L Sokolnicki, Joshua A. Bittker, Rajiv Narayan, Todd R. Golub, Wendy Winckler, Kejie Li, Jeremy R. Duvall, George B. Grant, Mathias Wawer, Aravind Subramanian, Mark-Anthony Bray, Melissa M. Kemp, Anne E. Carpenter, Bradley K. Taylor, Alykhan F. Shamji
Publikováno v:
Proceedings of the National Academy of Sciences. 111:10911-10916
High-throughput screening has become a mainstay of small-molecule probe and early drug discovery. The question of how to build and evolve efficient screening collections systematically for cell-based and biochemical screening is still unresolved. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c05190eb4d327c3eb9a28cd47962c91
https://doi.org/10.1073/pnas.1410933111
https://doi.org/10.1073/pnas.1410933111
Autor:
Yikai Wang, Alvin W. Hung, J. Anthony Wilson, Alexander Ramek, Damian W. Young, Taner Kaya, Paul A. Clemons
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6799-6804
Fragment-based drug discovery (FBDD) has proven to be an effective means of producing high-quality chemical ligands as starting points for drug-discovery pursuits. The increasing number of clinical candidate drugs developed using FBDD approaches is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fcab36d6230245cfcef3521c6245e0
https://doi.org/10.1073/pnas.1015271108
https://doi.org/10.1073/pnas.1015271108
Autor:
Bridget K. Wagner, Alykhan F. Shamji, Stuart L. Schreiber, Nicole E. Bodycombe, J. Anthony Wilson, Angela N. Koehler, Hyman A. Carrinski, Paul A. Clemons
Publikováno v:
Proceedings of the National Academy of Sciences. 107:18787-18792
Using a diverse collection of small molecules generated from a variety of sources, we measured protein-binding activities of each individual compound against each of 100 diverse (sequence-unrelated) proteins using small-molecule microarrays. We also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8380dac4d50c1e4a116986a5ab12fda4
https://doi.org/10.1073/pnas.1012741107
https://doi.org/10.1073/pnas.1012741107
Autor:
Giovanni Muncipinto, Stuart L. Schreiber, Paul A. Clemons, Naoya Kumagai, J. Anthony Wilson, Taner Kaya
Publikováno v:
Organic Letters
A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described. The change in shape of previous compounds and those in this study is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3af6e65ebe55f95068a2b97bb11019
http://europepmc.org/articles/PMC2979010
http://europepmc.org/articles/PMC2979010
Publikováno v:
Journal of Vision. 10:1-19
This study investigated the mechanisms of grouping and segregation in natural scenes of close-up foliage, an important class of scenes for human and non-human primates. Close-up foliage images were collected with a digital camera calibrated to match
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945a38070f0cdd9d44a053903076162b
https://doi.org/10.1167/10.4.10
https://doi.org/10.1167/10.4.10
Publikováno v:
Vision Research. 40:3685-3702
The spatio-temporal receptive fields (RFs) of cells in the macaque monkey lateral geniculate nucleus (LGN) and striate cortex (V1) have been examined and two distinct sub-populations of non-directional V1 cells have been found: those with a slow larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df491c04b6e9b638bc50e49bfc489f71
https://doi.org/10.1016/s0042-6989(00)00210-8
https://doi.org/10.1016/s0042-6989(00)00210-8
Autor:
Kathleen Petri Seiler, Deepika Walpita, Anne E. Carpenter, Hyman A. Carrel, Vebjorn Ljosa, Paul A. Clemons, Melissa M. Kemp, J. Anthony Wilson, Stuart L. Schreiber, Katherine L. Sokolnicki, Sigrun M. Gustafsdottir, Todd R. Golub, Alykhan F. Shamji
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling assay that “paints the cell” with as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db434b61724a0ae6ac397536563b3df9
https://pubmed.ncbi.nlm.nih.gov/24312513
https://pubmed.ncbi.nlm.nih.gov/24312513
Autor:
Sandrine Muller, Stuart L. Schreiber, Bridget K. Wagner, Vlado Dančík, Angela N. Koehler, J. Anthony Wilson, Hyman A. Carrinski, Paul A. Clemons
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(17)
Using a diverse collection of small molecules we recently found that compound sets from different sources (commercial; academic; natural) have different protein-binding behaviors, and these behaviors correlate with trends in stereochemical complexity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc55642fab7f08c51436a17d5736a14
https://pubmed.ncbi.nlm.nih.gov/21482810
https://pubmed.ncbi.nlm.nih.gov/21482810
Despite considerable efforts, description of molecular shape is still largely an unresolved problem. Given the importance of molecular shape in the description of spatial interactions in crystals or ligand-target complexes, this is not a satisfying s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860a1ab66f846737a99ecd27903c08cd
https://europepmc.org/articles/PMC3158582/
https://europepmc.org/articles/PMC3158582/
