Zobrazeno 1 - 10
of 148
pro vyhledávání: '"J Andrew Alspaugh"'
Autor:
Matthew J O'Meara, Jackson R Rapala, Connie B Nichols, A Christina Alexandre, R Blake Billmyre, Jacob L Steenwyk, J Andrew Alspaugh, Teresa R O'Meara
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011158 (2024)
Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation, and that complex relationships among
Externí odkaz:
https://doaj.org/article/65ef4ddc629c437bbbd2a8ec1d36b4e8
Autor:
Corinna Probst, Magnus Hallas-Møller, Johan Ø Ipsen, Jacob T Brooks, Karsten Andersen, Mireille Haon, Jean-Guy Berrin, Helle J Martens, Connie B Nichols, Katja S Johansen, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1010946 (2023)
Fungi often adapt to environmental stress by altering their size, shape, or rate of cell division. These morphological changes require reorganization of the cell wall, a structural feature external to the cell membrane composed of highly interconnect
Externí odkaz:
https://doaj.org/article/5b53086b515f485db0cf1679cf628b5d
Autor:
Corinna Probst, Sarela Garcia-Santamarina, Jacob T Brooks, Inge Van Der Kloet, Oliver Baars, Martina Ralle, Dennis J Thiele, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010195 (2022)
Copper homeostasis mechanisms are essential for microbial adaption to changing copper levels within the host during infection. In the opportunistic fungal pathogen Cryptococcus neoformans (Cn), the Cn Cbi1/Bim1 protein is a newly identified copper bi
Externí odkaz:
https://doaj.org/article/8aa673c0ea3e4b4ba86626efcff9d0ae
Autor:
Calla L Telzrow, Paul J Zwack, Shannon Esher Righi, Fred S Dietrich, Cliburn Chan, Kouros Owzar, J Andrew Alspaugh, Joshua A Granek
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
AbstractRNA sequencing (RNA-Seq) experiments focused on gene expression involve removal of ribosomal RNA (rRNA) because it is the major RNA constituent of cells. This process, called RNA enrichment, is done primarily to reduce cost: without rRNA remo
Externí odkaz:
https://doaj.org/article/1f1e7f4c0f8d42818c119b3b8b401db4
Autor:
Shannon K Esher, Kyla S Ost, Maria A Kohlbrenner, Kaila M Pianalto, Calla L Telzrow, Althea Campuzano, Connie B Nichols, Carol Munro, Floyd L Wormley, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 14, Iss 6, p e1007126 (2018)
The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and composition, upon entering the host. This cell wall remodeling is essential for host immune avoidance by this pathogen. In a genetic screen for mu
Externí odkaz:
https://doaj.org/article/eeac4427a615407a9b1fdb9e2afb7a60
Autor:
Fabiano de Assis Gontijo, Amanda Teixeira de Melo, Renata C Pascon, Larissa Fernandes, Hugo Costa Paes, J Andrew Alspaugh, Marcelo A Vallim
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177461 (2017)
In order to survive and cause disease, microbial pathogens must be able to proliferate at the temperature of their infected host. We identified novel microbial features associated with thermotolerance in the opportunistic fungal pathogen Cryptococcus
Externí odkaz:
https://doaj.org/article/3bc20b51f2374706a6db58c1906e161f
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005159 (2015)
The Rim101/PacC transcription factor acts in a fungal-specific signaling pathway responsible for sensing extracellular pH signals. First characterized in ascomycete fungi such as Aspergillus nidulans and Saccharomyces cerevisiae, the Rim/Pal pathway
Externí odkaz:
https://doaj.org/article/f30d6585ca414cb9b7145abbf5b614f3
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003687 (2013)
Proliferation and morphogenesis in eukaryotic cells depend on the concerted activity of Rho-type GTPases, including Ras, Cdc42, and Rac. The sexually dimorphic fungus Cryptococcus neoformans, which encodes paralogous, non-essential copies of all thre
Externí odkaz:
https://doaj.org/article/7362b4eb538749339cfb83ae02399eef
Autor:
Teresa R O'Meara, Diana Norton, Michael S Price, Christie Hay, Meredith F Clements, Connie B Nichols, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000776 (2010)
Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved pH-response regulator
Externí odkaz:
https://doaj.org/article/777a82eef5c1470b82c471276b45adc2
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6321 (2009)
BACKGROUND:Protein-O-mannosyltransferases (Pmt's) catalyze the initial step of protein-O-glycosylation, the addition of mannose residues to serine or threonine residues of target proteins. METHODOLOGY/PRINCIPAL FINDINGS:Based on protein similarities,
Externí odkaz:
https://doaj.org/article/f1342e211abb493bbce8a64bd3e9b81f