Výsledky vyhledávání - "J Andrew, Lockton"

Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial

Autor: J. Andrew Lockton, Richard Eastell, Richard D. Finkelman, Glen Clack, Rosemary A. Hannon, Martin Rimmer, Alan Swaisland

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 25(3)

Src is a nonreceptor tyrosine kinase thought to be essential for osteoclast function and bone resorption. We investigated the effect of the orally available Src inhibitor saracatinib (AZD0530) on bone turnover in healthy men. The study was part of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6860ba6ed6ae04990faf7befe83e85ee
https://pubmed.ncbi.nlm.nih.gov/19775203

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Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index

Autor: J. Andrew Lockton, Valentina Sukonina, Toralph Ruge, Maria Svensson, Frida Renström, Theodore Lystig, Jan W. Eriksson

Publikováno v: Metabolism: clinical and experimental. 58(6)

Hyperinsulinemia is a characteristic of type 2 diabetes mellitus (T2DM) and is believed to play a role in the low-grade inflammation seen in T2DM. The main aim was to study the effect of hyperinsulinemia on adipokines in individuals with different le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4734b585a461db942f6edf62927391a
https://pubmed.ncbi.nlm.nih.gov/19375766

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Single dose glucagon (0.5 mg IV bolus) administration in healthy human volunteers is a robust model for assessment of glycogenolysis: characterisation of the glucose excursion after glucagon challenge

Autor: J Andrew, Lockton, Simon M, Poucher

Publikováno v: Journal of pharmacological and toxicological methods. 55(1)

In the assessment of potential new treatments for Type 2 diabetes, robust pharmacological methods are helpful in assessing efficacy, defining dose response, duration of effect and ultimately in deciding whether to progress compounds to the next phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b56bd95db7c5bfe620590dbbeb503487
https://pubmed.ncbi.nlm.nih.gov/16716604

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Erratum: Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: A randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial

Autor: Rosemary A Hannon, Glen Clack, Martin Rimmer, Alan Swaisland, J Andrew Lockton, Richard D Finkelman, Richard Eastell

Publikováno v: Journal of Bone and Mineral Research. 27:1435-1435

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b40c538cae075d09722cf3e9bf5acbe0
https://doi.org/10.1002/jbmr.1557

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A retrospective study of thirty-two patients with small-cell bronchogenic carcinoma and inappropriate secretion of antidiuretic hormone

Autor: J. Andrew Lockton, N. Thatcher

Publikováno v: Clinical radiology. 37(1)

Thirty-two patients with inappropriate secretion of antidiuretic hormone (ADH) complicating small-cell carcinoma of the bronchus were identified from a total of 226 patients with small-cell carcinoma of the bronchus treated at the Christie Hospital,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1cc5c103e3281364f01a7de342a1dd
https://pubmed.ncbi.nlm.nih.gov/3006972

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