Zobrazeno 1 - 10
of 77
pro vyhledávání: '"J Andres Melendez"'
Publikováno v:
Journal of Oral Biology and Craniofacial Research, Vol 14, Iss 3, Pp 231-237 (2024)
Salivary gland hypofunction is highly prevalent in aged and diseased individuals leading to significant discomfort and morbidity. One factor that contributes to salivary gland hypofunction is cellular aging, or senescence. Senescent cells can impair
Externí odkaz:
https://doaj.org/article/5fe7c99c77404a5a83279b05dddca408
Autor:
Lauren Endres, Ulrike Begley, Ryan Clark, Chen Gu, Agnieszka Dziergowska, Andrzej Małkiewicz, J Andres Melendez, Peter C Dedon, Thomas J Begley
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131335 (2015)
Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translati
Externí odkaz:
https://doaj.org/article/927994c38bea431094899665c4138eaa
Autor:
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Publikováno v:
Epigenetics, Vol 15, Iss 10, Pp 1121-1138 (2020)
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alk
Externí odkaz:
https://doaj.org/article/d464ab1c8bef4c1bb173527d6328c626
Autor:
May Y Lee, Stephen Ojeda-Britez, Dylan Ehrbar, Antonia Samwer, Thomas J Begley, J Andres Melendez
Publikováno v:
Exp Biol Med (Maywood)
Selenium is a naturally found trace element, which provides multiple benefits including antioxidant, anticancer, and antiaging, as well as boosting immunity. One unique feature of selenium is its incorporation as selenocysteine, a rare 21st amino aci
PDF file - 34K, Catalase (CAT, 500U/ml) and N-acetylcysteine (NAC, 2mM) do not significantly inhibit 253J cell migration in a wound healing assay. Cells were pre-treated for 18 hours in complete media. Wound healing was carried out in 0% serum media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d02b70ee3d30578442bbb19148c818
https://doi.org/10.1158/1541-7786.22517197.v1
https://doi.org/10.1158/1541-7786.22517197.v1
Autor:
J. Andres Melendez, Badar M. Mian, Livingston Van De Water, James Belarmino, Aldo Gamarra, Ganary Dabiri, Kristin K. Nelson, Nadine Hempel, Kip M. Connor
Supplementary Movie 1 from Manganese Superoxide Dismutase Enhances the Invasive and Migratory Activity of Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae476125d93dfda8cc3cb53b6a226f7
https://doi.org/10.1158/0008-5472.22370886
https://doi.org/10.1158/0008-5472.22370886
Autor:
Akshaya Chandrasekaran, Habben Desta, Scott A. Tenenbaum, Shaheen Hasan, May Y Lee, J. Andres Melendez, Xuexin Zhang
Publikováno v:
Exp Biol Med (Maywood)
Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential but is accompanied by the often pathologically deleterious senescence-associated secretory phenotype (SASP). Here we demonstrate an H2O2-depe
Epitranscriptomic marks, in the form of enzyme catalyzed RNA modifications, play important gene regulatory roles in response to environmental and physiological conditions. However, little is known with respect to how pharmaceuticals influence the epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec795ded7e592ece3331fe17140410fe
https://doi.org/10.1101/2021.08.16.456530
https://doi.org/10.1101/2021.08.16.456530
Publikováno v:
Free Radic Biol Med
Here we highlight the role of epitranscriptomic systems in post-transcriptional regulation, with a specific focus on RNA modifying writers required for the incorporation of the 21(st) amino acid selenocysteine during translation, and the pathologies
Autor:
Emma Rocco, Fatemeh Shahedipour-Sandvik, J. Andres Melendez, Roger J Reinertsen, Benjamin McEwen, Kasey Hogan, Isra Mahaboob, Nathaniel C. Cady
Publikováno v:
Exp Biol Med (Maywood)
The results from this study demonstrate the potential of an AlGaN/GaN high electron mobility transistor sensor for the detection of reactive and transient biological molecules such as hydrogen peroxide. A boronate-based fluorescent probe was used wit