Zobrazeno 1 - 10
of 80
pro vyhledávání: '"J Alex Parker"'
Autor:
Kathrin Schmeisser, J Alex Parker
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007561 (2018)
Nicotinamide N-methyl-transferase (NNMT) is an essential contributor to various metabolic and epigenetic processes, including the regulating of aging, cellular stress response, and body weight gain. Epidemiological studies show that NNMT is a risk fa
Externí odkaz:
https://doaj.org/article/c8c82ce7ba854d74839f536c0ccca341
Autor:
Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, Robert J Ferrante, Wange Lu, Christian Neri
Publikováno v:
PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway
Externí odkaz:
https://doaj.org/article/30fe5f15c42b4abcbb453493275b5e19
Autor:
Arnaud Tauffenberger, J Alex Parker
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004346 (2014)
Glucose is a major energy source and is a key regulator of metabolism but excessive dietary glucose is linked to several disorders including type 2 diabetes, obesity and cardiac dysfunction. Dietary intake greatly influences organismal survival but w
Externí odkaz:
https://doaj.org/article/efd6ec5d244542058c2dcd1d08873a3f
Autor:
Martine eTherrien, J Alex Parker
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
Neurodegenerative diseases share pathogenic mechanisms at the cellular level including protein misfolding, excitotoxicity and altered RNA homeostasis among others. Recent advances have shown that the genetic causes underlying these pathologies overla
Externí odkaz:
https://doaj.org/article/a8cfb7e1b58142c5a06a577c3d9dc6a4
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83450 (2013)
An expansion of the hexanucleotide GGGGCC repeat in the first intron of C9ORF72 gene was recently linked to amyotrophic lateral sclerosis. It is not known if the mutation results in a gain of function, a loss of function or if, perhaps both mechanism
Externí odkaz:
https://doaj.org/article/af36c107a2a549d085f1e2395801d139
Autor:
Alexandra Vaccaro, Arnaud Tauffenberger, Peter E A Ash, Yari Carlomagno, Leonard Petrucelli, J Alex Parker
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002806 (2012)
TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia. To learn more about the normal biological and abnormal pathological role
Externí odkaz:
https://doaj.org/article/cf353680b8cc493996134dfcf2d0b626
Autor:
Alexandra Vaccaro, Shunmoogum A Patten, Sorana Ciura, Claudia Maios, Martine Therrien, Pierre Drapeau, Edor Kabashi, J Alex Parker
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42117 (2012)
The DNA/RNA-binding proteins TDP-43 and FUS are found in protein aggregates in a growing number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and related dementia, but little is known about the neurotoxic mechanisms. We
Externí odkaz:
https://doaj.org/article/e4b8648f7d3a4e61846ae8092628a8bc
Autor:
Alexandra Vaccaro, Arnaud Tauffenberger, Dina Aggad, Guy Rouleau, Pierre Drapeau, J Alex Parker
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31321 (2012)
Mutations in the DNA/RNA binding proteins TDP-43 and FUS are associated with Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular accumulations of wild type TDP-43 and FUS are observed in a growing number of late-onset d
Externí odkaz:
https://doaj.org/article/b362d351f82c43b4b89cbd5cfdab77cd
Autor:
Kathrin Schmeisser, J. Alex Parker
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Autophagy as a ubiquitous catabolic process causes degradation of cytoplasmic components and is generally considered to have beneficial effects on health and lifespan. In contrast, inefficient autophagy has been linked with detrimental effects on the
Externí odkaz:
https://doaj.org/article/f1eb87d633234e01813551175e7870f7
Autor:
Gilles Tossing, Raphaël Livernoche, Claudia Maios, Constantin Bretonneau, Audrey Labarre, J Alex Parker
Publikováno v:
Human Molecular Genetics. 31:3313-3324
Axonal degeneration is observed in early stages of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). This degeneration generally precedes apoptosis and therefore may be a promising therapeutic target. An increasing nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb48a9a2cc00f5d49fdd2479493c324
https://doi.org/10.1093/hmg/ddac116
https://doi.org/10.1093/hmg/ddac116