Zobrazeno 1 - 10
of 80
pro vyhledávání: '"J Alex, Parker"'
Autor:
Audrey Labarre, Ericka Guitard, Gilles Tossing, Anik Forest, Eric Bareke, Marjorie Labrecque, Martine Tétreault, Matthieu Ruiz, J. Alex Parker
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
A probiotic bacterial strain (Lacticaseibacillus rhamnosus) delays neurodegeneration phenotypes in C. elegans models of amyotrophic lateral sclerosis and Huntington’s disease, with fatty acid extracts from the bacteria able to reproduce the protect
Externí odkaz:
https://doaj.org/article/d4113e284c59414499856b89a89a1b1e
Autor:
Elite Possik, Clémence Schmitt, Anfal Al-Mass, Ying Bai, Laurence Côté, Johanne Morin, Heidi Erb, Abel Oppong, Wahab Kahloan, J. Alex Parker, S. R. Murthy Madiraju, Marc Prentki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Glycerol-3-phosphate phosphatase is a recently discovered enzyme at the heart of metabolism. Here, the authors used C. elegans and showed that its activation promotes stress resistance, healthy aging and acts as a calorie restriction mimetic at norma
Externí odkaz:
https://doaj.org/article/7ec50e33ccdf4e78a7f7c66bddf1bd95
Autor:
James J. Doyle, Celine Vrancx, Claudia Maios, Audrey Labarre, Shunmoogum A. Patten, J. Alex Parker
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 12 (2020)
Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease resulting in muscle atrophy and neurodegeneration, and is the leading genetic cause of infant death. SMA arises when there are homozygous deletion mutations in t
Externí odkaz:
https://doaj.org/article/351f869cff464f608dc1c8fa6a044ccb
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1465-1480 (2017)
Polyglutamine expansion diseases are a group of hereditary neurodegenerative disorders that develop when a CAG repeat in the causative genes is unstably expanded above a certain threshold. The expansion of trinucleotide CAG repeats causes hereditary
Externí odkaz:
https://doaj.org/article/29fd4f1f360644e3883b87339472b668
Autor:
Francesca Farina, Emmanuel Lambert, Lucie Commeau, François-Xavier Lejeune, Nathalie Roudier, Cosima Fonte, J. Alex Parker, Jacques Boddaert, Marc Verny, Etienne-Emile Baulieu, Christian Neri
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Helping neurons to compensate for proteotoxic stress and maintain function over time (neuronal compensation) has therapeutic potential in aging and neurodegenerative disease. The stress response factor FOXO3 is neuroprotective in models of H
Externí odkaz:
https://doaj.org/article/6708c811da8d48d8a864bd74cd34faa5
Autor:
Kathrin Schmeisser, J. Alex Parker
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Autophagy as a ubiquitous catabolic process causes degradation of cytoplasmic components and is generally considered to have beneficial effects on health and lifespan. In contrast, inefficient autophagy has been linked with detrimental effects on the
Externí odkaz:
https://doaj.org/article/f1eb87d633234e01813551175e7870f7
Autor:
Gilles Tossing, Raphaël Livernoche, Claudia Maios, Constantin Bretonneau, Audrey Labarre, J Alex Parker
Publikováno v:
Human Molecular Genetics. 31:3313-3324
Axonal degeneration is observed in early stages of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). This degeneration generally precedes apoptosis and therefore may be a promising therapeutic target. An increasing nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb48a9a2cc00f5d49fdd2479493c324
https://doi.org/10.1093/hmg/ddac116
https://doi.org/10.1093/hmg/ddac116
Autor:
Kathrin Schmeisser, J Alex Parker
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007561 (2018)
Nicotinamide N-methyl-transferase (NNMT) is an essential contributor to various metabolic and epigenetic processes, including the regulating of aging, cellular stress response, and body weight gain. Epidemiological studies show that NNMT is a risk fa
Externí odkaz:
https://doaj.org/article/c8c82ce7ba854d74839f536c0ccca341
Autor:
Eric Bareke, Ze'ev Melamed, Laurie Destroimaisons, Lorne Zinman, Geneviève Di Tomasso, Elizabeth M. H. Tank, Martine Tétreault, Pascale Legault, Anaïs Aulas, Jade-Emmanuelle Deshaies, Sami J. Barmada, Shangxi Xiao, J. Alex Parker, Janice Robertson, Hana Fakim, Christine Vande Velde, Hadjara Sidibé, Paul M. McKeever, Nicolás B. Gómez, Yousra Khalfallah
Publikováno v:
Brain
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a2a74325fd31df4145b13e88f6ded
http://europepmc.org/articles/PMC8677511
http://europepmc.org/articles/PMC8677511
Autor:
Shunmoogum A. Patten, Gary A. B. Armstrong, Alexandra Lissouba, Edor Kabashi, J. Alex Parker, Pierre Drapeau
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 799-809 (2014)
Motor neuron disorders (MNDs) are a clinically heterogeneous group of neurological diseases characterized by progressive degeneration of motor neurons, and share some common pathological pathways. Despite remarkable advances in our understanding of t
Externí odkaz:
https://doaj.org/article/33a4d3f79b8b40ee8b7af73ffde458cf