Zobrazeno 1 - 10
of 207
pro vyhledávání: '"J Alberto, Marco"'
Autor:
Raül Agut, Eva Falomir, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Alberto Marco
Publikováno v:
Molecules, Vol 25, Iss 3, p 660 (2020)
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3′-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have been sy
Externí odkaz:
https://doaj.org/article/d97df8b1a8284e0eae58c401f6fc96f9
Publikováno v:
ARKIVOC, Vol 2005, Iss 9, Pp 175-188 (2005)
Externí odkaz:
https://doaj.org/article/cc4c5b1546a745eda4eedbd910e09d0e
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these designed molecules display a urea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60dfaed2376a654c0a825c8e6f5d8e93
https://doi.org/10.1016/j.ejmech.2019.03.012
https://doi.org/10.1016/j.ejmech.2019.03.012
Autor:
J. Alberto Marco, Eva Falomir, Alberto Pla, J. Fernando Díaz, Celia Martín-Beltrán, Fernando Josa-Prado, Juan Murga, Raül Agut, Raquel Gil-Edo, Miguel Carda
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
11 p.-9 fig.-4 tab.
Background: Six N-acyl derivatives of aminocombretastatin A-4 have been synthesized and evaluated according to their interaction with tubulin and as c-Myc downregulators.
Aims: In search of new promising anti-cancer agen
Background: Six N-acyl derivatives of aminocombretastatin A-4 have been synthesized and evaluated according to their interaction with tubulin and as c-Myc downregulators.
Aims: In search of new promising anti-cancer agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e589f42d518cfa688d0f8c7dd8cbf0f
https://pubmed.ncbi.nlm.nih.gov/33222678
https://pubmed.ncbi.nlm.nih.gov/33222678
Publikováno v:
European Journal of Medicinal Chemistry. 162:781-792
Twenty-six compounds derived from 3′-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative activity of all the synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d72760a4c7fce15952e5f0b362dd4b1
https://doi.org/10.1016/j.ejmech.2018.11.023
https://doi.org/10.1016/j.ejmech.2018.11.023
Autor:
Raquel Gil-Edo, J. Alberto Marco, Eva Falomir, Juan Murga, Celia Martín-Beltrán, Raül Agut, Miguel Carda, Alberto Pla
Publikováno v:
Molecules, Vol 25, Iss 3, p 660 (2020)
Molecules
Volume 25
Issue 3
Molecules
Volume 25
Issue 3
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3&prime
aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have
aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc37cbb62585fd172003546e8946b3e
https://www.mdpi.com/1420-3049/25/3/660
https://www.mdpi.com/1420-3049/25/3/660
Publikováno v:
Natural product communications. 12(5)
A group of 28 N-benzylidene aniline derivatives structurally related to the natural stilbene resveratrol has been prepared through condensation of anilines with the corresponding aldehydes. The ability of these imines to inhibit proliferation of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bc51269fc8df91f26670211d050c94b
https://pubmed.ncbi.nlm.nih.gov/30496679
https://pubmed.ncbi.nlm.nih.gov/30496679
Autor:
Miguel Carda, Eva Falomir, Laura Conesa-Milián, J. Alberto Marco, María Sánchez-Peris, Celia Martín-Beltrán, Juan Murga
Publikováno v:
Bioorganicmedicinal chemistry. 27(5)
Twenty-four derivatives structurally related to honokiol have been synthesized and biologically evaluated. IC50 values were determined towards the HT-29, MCF-7 and HEK-293 cell lines. Some of these derivatives exhibited comparable or lower IC50 value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26748c7ea0436cfa4e44dee56053ae16
https://pubmed.ncbi.nlm.nih.gov/30733086
https://pubmed.ncbi.nlm.nih.gov/30733086
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
A group of thirty-nine stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity, as well as for their ability to inhibit the production of the vascular endothelial growth factor (VEGF) and the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b98238a7cc0382f4fa61409dc0aae1
https://doi.org/10.1016/j.ejmech.2015.09.014
https://doi.org/10.1016/j.ejmech.2015.09.014
Autor:
Juan Murga, Eva Falomir, J. Alberto Marco, Ana C. Cuñat, Juan F. Sanz-Cervera, Miguel Carda, Víctor Blasco
Publikováno v:
European journal of medicinal chemistry. 150
Our efforts to get therapeutically useful colchicine derivatives for the treatment of cancer have led us to synthetize and biologically evaluate twenty-seven N,N′-disubstituted ureas containing a colchicine moiety and an aryl fragment. The cytotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dfcc567710b85afbb8d5fb0fe7653f
https://pubmed.ncbi.nlm.nih.gov/29604583
https://pubmed.ncbi.nlm.nih.gov/29604583