Zobrazeno 1 - 10
of 57
pro vyhledávání: '"J Alan Maschek"'
Autor:
Diana Cortes-Selva, Lisa Gibbs, J Alan Maschek, Marcia Nascimento, Tyler Van Ry, James E Cox, Eyal Amiel, Keke C Fairfax
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009198 (2021)
Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation of macrophages is thought to be beneficial to both glucose and cholesterol metabolism during high fat diet induced diseas
Externí odkaz:
https://doaj.org/article/96328531bcf34c72b676ecc76187576b
Autor:
Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter
Publikováno v:
eLife, Vol 9 (2020)
Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major
Externí odkaz:
https://doaj.org/article/f28d705b3f05490b91c7e479d58b568b
Autor:
Marie K. Norris, Trevor S. Tippetts, Joseph L. Wilkerson, Rebekah J. Nicholson, J. Alan Maschek, Thierry Levade, Jeffrey A. Medin, Scott A. Summers, William L. Holland
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 39, Iss , Pp 101077- (2024)
Farber Disease is a debilitating and lethal childhood disease of ceramide accumulation caused by acid ceramidase deficiency. The potent induction of a ligand-gated neutral ceramidase activity promoted by adiponectin may provide sufficient lowering of
Externí odkaz:
https://doaj.org/article/fd1f0a9001544ffca316b6e632fe7b03
Autor:
Justin L. Shahtout, Hiroaki Eshima, Patrick J. Ferrara, J. Alan Maschek, James E. Cox, Micah J. Drummond, Katsuhiko Funai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 319-330 (2024)
Abstract Background Lipid hydroperoxides (LOOH) have been implicated in skeletal muscle atrophy with age and disuse. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), an enzyme of the Lands cycle, conjugates a polyunsaturated fatty acyl chain to a
Externí odkaz:
https://doaj.org/article/7c0fa7d511e2444a85949c4cde575b28
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80277 (2013)
Antarctica's rich marine animal biodiversity has been substantially influenced by a complex glacial history, but it is unclear why some taxa responded with diversification while others did not. Despite being considered a single endemic sea slug speci
Externí odkaz:
https://doaj.org/article/c6fb2bfc684c4e1e94baa749e7e8bb77
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100518- (2024)
Very-long-chain PUFAs (VLC-PUFAs) are a group of lipids with chain lengths >24 carbons, and the ELOVL4 (elongation of very-long-chain FA-4) enzyme is responsible for vertebrate VLC-PUFA biosynthesis. Studies on the role of VLC-PUFAs in vision have be
Externí odkaz:
https://doaj.org/article/f2370b880fad4f62b80321048cf2e963
Autor:
Joni Nikkanen, Yew Ann Leong, William C. Krause, Denis Dermadi, J. Alan Maschek, Tyler Van Ry, James E. Cox, Ethan J. Weiss, Omer Gokcumen, Ajay Chawla, Holly A. Ingraham
Publikováno v:
Science
Science (New York, N.Y.), vol 378, iss 6617
Science (New York, N.Y.), vol 378, iss 6617
Adaptations to infectious and dietary pressures shape mammalian physiology and disease risk. How such adaptations affect sex-biased diseases remains insufficiently studied. In this study, we show that sex-dependent hepatic gene programs confer a robu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b9c9fd313955bccc91835d377ad0dc
https://doi.org/10.1126/science.abn9886
https://doi.org/10.1126/science.abn9886
Autor:
Douglas Grossman, Matthew W. VanBrocklin, James E. Cox, J. Alan Maschek, Sheri L. Holmen, David Lum, Ran Lu, Chelsea Li, Tong Liu, Ethika Tyagi, Hafeez Rahman, Dileep Kumar
S1. Effect of ASA on cell viability. S2. Effect of Celecoxib on cell viability and migration. S3. Mice are tolerant of chronic dailly gavage. S4. ASA delays tumor growth of cell implants. S5. ASA does not delay tumor growth of some cell implants. S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eec51f6fcd0b514b104ee962b236131
https://doi.org/10.1158/1940-6207.22534262
https://doi.org/10.1158/1940-6207.22534262
Autor:
Douglas Grossman, Matthew W. VanBrocklin, James E. Cox, J. Alan Maschek, Sheri L. Holmen, David Lum, Ran Lu, Chelsea Li, Tong Liu, Ethika Tyagi, Hafeez Rahman, Dileep Kumar
There are conflicting epidemiologic data on whether chronic aspirin (ASA) use may reduce melanoma risk in humans. Potential anticancer effects of ASA may be mediated by its ability to suppress prostaglandin E2 (PGE2) production and activate 5′-aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5a6fada4347103650cf0c9ca84cd5a
https://doi.org/10.1158/1940-6207.c.6547436.v1
https://doi.org/10.1158/1940-6207.c.6547436.v1
Autor:
Mark Li, Roger R. Berton, Qingwen Qian, J. Alan Maschek, Biyi Chen, Elizabeth Barroso, Adam J. Rauckhorst, Thomas S. Griffith, Eric B. Taylor, Vladimir P. Badovinac, Gökhan S. Hotamisligil, Long-Sheng Song, Ling Yang
SUMMARY Metabolic reprogramming in response to infection plays a critical role for septic survival. During a septic episode, the heart heavily relies on hepatic lipid particles to prevent heart damage and failure. Inositol- Requiring Enzyme 1 (IRE1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ff1d584873e047179a87d589632e7fc
https://doi.org/10.1101/2023.03.14.532202
https://doi.org/10.1101/2023.03.14.532202