Zobrazeno 1 - 10
of 17
pro vyhledávání: '"J Alan, Menius"'
Autor:
Christine M. Hunt, Xiwu Lin, Lloyd Curtis, Kwan R. Lee, J. Alan Menius, Jie Cheng, Colin F. Spraggs, Jeffery L. Painter, Jeanenne J. Nelson, Daniel Parks
Publikováno v:
Pharmacoepidemiology and Drug Safety. 22:571-578
Purpose Identifying drug-induced liver injury is a critical task in drug development and postapproval real-world care. Severe liver injury is identified by the liver chemistry threshold of alanine aminotransferase (ALT) >3× upper limit of normal (UL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd9e0f3c7ffda9b35a034bf1ccacef62
https://doi.org/10.1002/pds.3405
https://doi.org/10.1002/pds.3405
Publikováno v:
Statistics in Biopharmaceutical Research. 3:506-514
Recent analysis of microarray data has focused on identifying groups of genes that show statistically significant changes in their expression activity. Using annotation databases, genes are grouped into predefined sets based on common characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::324d9ba8c18d61c42171adb9ab140f2e
https://doi.org/10.1198/sbr.2009.09029
https://doi.org/10.1198/sbr.2009.09029
Autor:
J. Alan Menius, Matthew D. Rousculp
Publikováno v:
North Carolina Medical Journal. 75:188-190
A health care ecosystem is evolving in which all stakeholders will need to work together, apply new technologies, and use disparate data sources to gain insights, increase efficiencies, and improve patient outcomes. The pharmaceutical industry is lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ad057733442c3a7efc4fa6022e60ae
https://doi.org/10.18043/ncm.75.3.188
https://doi.org/10.18043/ncm.75.3.188
Autor:
David L. Saussy, J. Alan Menius, Tony D. Choi, Michael W. Lutz, Aaron S. Goetz, Paul L. Domanico, Rebecca Gooding Laskody
Publikováno v:
Drug Discovery Today. 1:277-286
Novel methods in molecular biology and advanced technologies have given pharmaceutical research laboratories the capability to test combinatorial libraries rapidly against large numbers of potential targets. Methods to identify optimal assay conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595cd01979be6f610071f9a3331205e4
https://doi.org/10.1016/1359-6446(96)10025-8
https://doi.org/10.1016/1359-6446(96)10025-8
Autor:
Daniel, Parks, Xiwu, Lin, Jeffery L, Painter, Jie, Cheng, Christine M, Hunt, Colin F, Spraggs, Jeanenne J, Nelson, Lloyd, Curtis, J Alan, Menius, Kwan R, Lee
Publikováno v:
Pharmacoepidemiology and drug safety. 22(6)
Identifying drug-induced liver injury is a critical task in drug development and postapproval real-world care. Severe liver injury is identified by the liver chemistry threshold of alanine aminotransferase (ALT)3× upper limit of normal (ULN) and bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7801f0ed9b137fe90f1106bfd827333b
https://pubmed.ncbi.nlm.nih.gov/23512228
https://pubmed.ncbi.nlm.nih.gov/23512228
Publikováno v:
Bioinformatics (Oxford, England). 23(10)
Motivation: New biological systems technologies give scientists the ability to measure thousands of bio-molecules including genes, proteins, lipids and metabolites. We use domain knowledge, e.g. the Gene Ontology, to guide analysis of such data. By f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01557ce55bcbeb03172f386edb316b5
https://pubmed.ncbi.nlm.nih.gov/17379692
https://pubmed.ncbi.nlm.nih.gov/17379692
Autor:
Michael W. Lutz, Paul H. Morgan, Mauro Corsi, Terrence Peter Kenakin, J. Alan Menius, Charu Krishnamoorthy, Thomas J. Rimele
Publikováno v:
Journal of pharmacological and toxicological methods. 34(1)
Estimates of variance in pharmacological assays are usually made by repeating the experiment with different tissues. Biological factors, such as the inability to wash a drug from tissue, may preclude the type of replication that is appropriate for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8674961194a692f69cf7579e738de0f5
https://pubmed.ncbi.nlm.nih.gov/7496045
https://pubmed.ncbi.nlm.nih.gov/7496045
Autor:
MARK P. ANSTADT, MICHAEL J. STONNINGTON, MARK TEDDER, BARBARA J. CRAIN, MICHAEL F. BROTHERS, DAVID J. HILLEREN, RICHARD J. RAHIJA, J. ALAN MENIUS, JAMES E. LOWE
Publikováno v:
Annals of surgery. 214(4)
Cardiopulmonary bypass (CPB) using nonpulsatile flow (NPF) is advocated for refractory cardiac arrest. This study examined cerebral outcome after resuscitation with pulsatile flow (PF) versus NPF. Dogs arrested for 12.5 minute were reperfused with NP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802637414b7e6439ba9fb826005b88fd
https://pubmed.ncbi.nlm.nih.gov/1953100
https://pubmed.ncbi.nlm.nih.gov/1953100
Autor:
J. Alan Menius, John B. Pollard, Joseph G. Reves, James E. Lowe, Robin G. Cummings, Russell F. Hill, Diane M. Simeone
Publikováno v:
Anesthesiology. 69:17-23
Myocardial tolerance to total ischemia was compared in animals anesthetized with halothane or isoflurane by measuring the time required for development of cardiac rigor in the absence of coronary circulation or wall stress. Sixteen dogs, eight in eac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c5a0a0f092cc69d1f39594ece9da71
https://doi.org/10.1097/00000542-198807000-00003
https://doi.org/10.1097/00000542-198807000-00003
Autor:
Cyril Y. Leung, James E. Lowe, Robin G. Cummings, D. James Schumacher, J. Alan Menius, Emily A. Hull-Ryde
Publikováno v:
Journal of Liquid Chromatography. 10:2625-2637
A new method for quantitating amiodarone and its metabolite desethylamiodarone from serum and myocardial tissue is described. Serum and tissue components are initially removed before analysis with C18 solid phase extraction columns. Quantitation is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71a091a6415e541b4ea3a8e1035f29a9
https://doi.org/10.1080/01483918708066817
https://doi.org/10.1080/01483918708066817