Zobrazeno 1 - 10
of 4 761
pro vyhledávání: '"J Alan"'
Autor:
Diana Cortes-Selva, Lisa Gibbs, J Alan Maschek, Marcia Nascimento, Tyler Van Ry, James E Cox, Eyal Amiel, Keke C Fairfax
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009198 (2021)
Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation of macrophages is thought to be beneficial to both glucose and cholesterol metabolism during high fat diet induced diseas
Externí odkaz:
https://doaj.org/article/96328531bcf34c72b676ecc76187576b
Autor:
Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter
Publikováno v:
eLife, Vol 9 (2020)
Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major
Externí odkaz:
https://doaj.org/article/f28d705b3f05490b91c7e479d58b568b
Autor:
Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J. Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S. Herter-Sprie, Gang Lu, Xin Zhang, Bryan P. Marsh, Stephanie J. Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A. Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M. Sholl, Anil K. Rustgi, David J. Kwiatkowski, J Alan Diehl, Adam J. Bass, Norman E. Sharpless, Glenn Dranoff, Peter S. Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F. Kim, Kwok-Kin Wong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chr
Externí odkaz:
https://doaj.org/article/0ce62822a53e4bae828250fb78660d57
Autor:
Diriba B Kumssa, Beth Penrose, Peter A Bone, J Alan Lovatt, Martin R Broadley, Nigel R Kendall, E Louise Ander
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223868 (2019)
Hypomagnesaemic tetany (HypoMgT) in ruminants is a physiological disorder caused by inadequate intake or impaired absorption of magnesium (Mg) in the gut. If it is not detected and treated in time, HypoMgT can cause the death of the affected animal.
Externí odkaz:
https://doaj.org/article/d7c6ce48292d46ff9a48ff3800006ec8
Autor:
Dustin R Partridge, J Alan Clark
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202298 (2018)
The world is rapidly urbanizing, and many previously biodiverse areas are now mostly composed of impervious surface. This loss of natural habitat causes local bird communities to become dominated by urban dweller and urban utilizer species and reduce
Externí odkaz:
https://doaj.org/article/61e6435cef0e454187e254928a317079
Autor:
Alexander McQuiston, J Alan Diehl
Publikováno v:
F1000Research, Vol 6 (2017)
The unfolded protein response (UPR) is an evolutionarily conserved stress response to intra- and extracellular conditions that disrupt endoplasmic reticulum (ER) protein-folding capacity. The UPR is engaged by a variety of disease conditions, includi
Externí odkaz:
https://doaj.org/article/7b0920349cd54fd0b0ad9787d9065a51