Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J Adriaan, Bouwknecht"'
Publikováno v:
Journal of Biopharmaceutical Statistics. 20:759-767
The accelerating rotarod test is a preclinical pharmacodynamic test to assess the effect of a treatment on an animal's motor coordination. Two models are proposed to analyze the dose-response time-to-event data that typically result from such experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1512652e2fd024c103035e39dcb3bfc
https://doi.org/10.1080/10543401003618249
https://doi.org/10.1080/10543401003618249
Autor:
J. Adriaan Bouwknecht, Thomas Steckler, Jesús Alcázar, Frank M. Dautzenberg, Abdellah Ahnaou, Wilhelmus Drinkenburg
Publikováno v:
European Journal of Pharmacology. 579:177-188
Melanin-concentrating hormone (MCH) is a hypothalamic peptide that centrally regulates food intake, energy balance and emotion. Interestingly, MCH and melanin-concentrating hormone MCH(1) receptors are distributed in brain areas known to regulate vig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70577affa2fe56cf3716b60996cdc1ca
https://doi.org/10.1016/j.ejphar.2007.10.017
https://doi.org/10.1016/j.ejphar.2007.10.017
Autor:
Thomas Steckler, Itzhak Levi, Yuly Bersudsky, Galila Agam, Stefan Kass, Dieder Moechars, Luc Andries, Nathalie Van Acker, Kim Cryns, J. Adriaan Bouwknecht, Haim Belmaker, Guy Daneels, Alon Shamir, Ilse Goris
Publikováno v:
Neuropsychopharmacology. 33:674-684
Lithium has been the standard pharmacological treatment for bipolar disorder over the last 50 years; however, the molecular targets through which lithium exerts its therapeutic effects are still not defined. We characterized the phenotype of mice wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98052b67cbc50ca4c1eab4e4d74fa71a
https://doi.org/10.1038/sj.npp.1301431
https://doi.org/10.1038/sj.npp.1301431
Autor:
Ilse Goris, Hansfried Van Craenendonck, Guy Daneels, Dieder Moechars, Ilse Lenaerts, J. Adriaan Bouwknecht, Thomas Steckler, Kim Cryns, Jos Prickaerts
Publikováno v:
Journal of Neuroscience, 26, 9022-9. Society for Neuroscience
Lithium is used as treatment for bipolar disorder with particular efficacy in the treatment of mania. Lithium inhibits glycogen synthase kinase 3 beta(GSK-3 beta) directly or indirectly via stimulation of the kinase Akt-1. We therefore investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61f52254e728bce2ce7962a0cebb27a
https://doi.org/10.1523/jneurosci.5216-05.2006
https://doi.org/10.1523/jneurosci.5216-05.2006
Autor:
DM Knight, Jolane K. Abrams, J. Adriaan Bouwknecht, Anantha Shekhar, Andrew K. Evans, Christopher A. Lowry
Publikováno v:
Pharmacology Biochemistry and Behavior. 84:266-274
The neural mechanisms underlying anxiety states are believed to involve interactions among forebrain limbic circuits and brainstem serotonergic systems. Consistent with this hypothesis, FG-7142, a partial inverse agonist at the benzodiazepine alloste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b03abe8d1a710c5a409f681789e02a6
https://doi.org/10.1016/j.pbb.2006.05.007
https://doi.org/10.1016/j.pbb.2006.05.007
Publikováno v:
European Journal of Pharmacology. 494:35-44
Over the last decade, many genetically modified mice have been developed as models for psychiatric diseases such as anxiety. Limited availability of such mutant mice highlights the importance of studying the possibility of repeatedly testing the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74623429f59e95ca613b59c2ea9cfe95
https://doi.org/10.1016/j.ejphar.2004.04.036
https://doi.org/10.1016/j.ejphar.2004.04.036
Publikováno v:
European Journal of Pharmacology. 494:45-53
Serotonin 1A (5-HT 1A ) receptors are involved in anxiety. This study focuses on the role of genetic factors on the anxiety-related effects of 5-HT 1A receptor stimulation using both a within subject design. The effects of 5-HT 1A receptor activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cfc490c0f82c662582661e64b11341
https://doi.org/10.1016/j.ejphar.2004.04.037
https://doi.org/10.1016/j.ejphar.2004.04.037
Autor:
Jan van der Gugten, Berend Olivier, René Hen, J. Adriaan Bouwknecht, Theo H. Hijzen, Robert A. A. Maes
Publikováno v:
Brain Research Bulletin. 57:93-102
Two presynaptic receptors play an important role in the regulation of serotonergic neurotransmission, i.e., the 5-HT(1A) and 5-HT(1B) receptor. The present study focuses on putative adaptive changes in the 5-HT(1A) receptor system in mice that lack 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90616b82eaf6c02ee9868858a62cf07d
https://doi.org/10.1016/s0361-9230(01)00640-2
https://doi.org/10.1016/s0361-9230(01)00640-2
Autor:
J. Adriaan Bouwknecht
Publikováno v:
European journal of pharmacology. 753
The review describes a personal journey through 25 years of animal research with a focus on the contribution of rodent models for anxiety and depression to the development of new medicines in a drug discovery environment. Several classic acute models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472828ceef54fbeb28855dfe8e98b45e
https://pubmed.ncbi.nlm.nih.gov/25460021
https://pubmed.ncbi.nlm.nih.gov/25460021
Absence of 5-HT1B receptors is associated with impaired impulse control in male 5-HT1B knockout mice
Autor:
Theo H. Hijzen, René Hen, Berend Olivier, Robert A. A. Maes, Jan van der Gugten, J. Adriaan Bouwknecht
Publikováno v:
Biological Psychiatry. 49:557-568
Background: Serotonin (5-HT) plays a complex regulatory role in processes like anxiety, depression, aggression, and impulse control. Due to the large amount of serotonergic receptors, knockout mice offer an important opportunity to investigate the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd1b594e7486b8846c8e05c1b96fb8b
https://doi.org/10.1016/s0006-3223(00)01018-0
https://doi.org/10.1016/s0006-3223(00)01018-0