Zobrazeno 1 - 10
of 29
pro vyhledávání: '"J A Trapani"'
Autor:
L. H. Porter, J. J. Zhu, N. L. Lister, S. G. Harrison, S. Keerthikumar, D. L. Goode, R. Quezada Urban, D. J. Byrne, A. Azad, I. Vela, M. S. Hofman, P. J. Neeson, P. K. Darcy, J. A. Trapani, R. A. Taylor, G. P. Risbridger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chimeric antigen receptor (CAR) T cells have transformed the treatment landscape for hematological malignancies. However, CAR T cells are less efficient against solid tumors, largely due to poor infiltration resulting from the immunosuppress
Externí odkaz:
https://doaj.org/article/eb8dadc0a7e045c7b9cf4a1d7631aa08
Autor:
M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-depende
Externí odkaz:
https://doaj.org/article/a16f075282c8487babc56ea336c15431
Publikováno v:
Methods in cell biology. 133
During sensory transduction, external physical stimuli are translated into an internal biological signal. In vertebrates, hair cells are specialized mechanosensory receptors that transduce sound, gravitational forces, and head movements into electric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16ce18bd7d03200c8ce6ce0c784b83c8
https://pubmed.ncbi.nlm.nih.gov/27263416
https://pubmed.ncbi.nlm.nih.gov/27263416
Publikováno v:
The Journal of Immunology. 158:5783-5790
Two pathways have been implicated in the induction of apoptosis by cytotoxic T cells: the granule exocytosis pathway and a pathway using CD95 (Fas/APO-1). To test whether apoptosis induced by either of these pathways could be blocked by Bcl-2, we exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd13c4bf05b3126d29f323db5b72fc8
https://doi.org/10.4049/jimmunol.158.12.5783
https://doi.org/10.4049/jimmunol.158.12.5783
Publikováno v:
Tissue antigens. 80(6)
Granzymes (Grz) are a family of serine proteases found in the granules of cytotoxic lymphocytes and are emerging as an important group of proteins involved in immune function and surveillance. Grz have both cytotoxic and more recently reported non-cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c2bf103d01f596849f1fdeabef45c13
https://pubmed.ncbi.nlm.nih.gov/23137319
https://pubmed.ncbi.nlm.nih.gov/23137319
Publikováno v:
The Journal of Immunology. 149:1636-1641
We describe the production and characterization of a mouse mAb, S-450-33.2, recognizing the Ly-9.2 specificity. This mAb was used to purify Ly-9 molecules from lymphoid cell lines, and the amino-terminal amino acids were determined. The mAb was also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b81ddd5c0ac91dc86d0b9587512c9a
https://doi.org/10.4049/jimmunol.149.5.1636
https://doi.org/10.4049/jimmunol.149.5.1636
Publikováno v:
Current drug targets. Immune, endocrine and metabolic disorders. 1(2)
Interferons (IFNs) are an important part of immune responses and are believed to protect the host from viral and bacterial pathogens as well as having a role in rejection of malignancies. The well-known anti-viral and cytostatic properties of IFNs ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aaa7540efe56f159009e3807f1d0cbb3
https://pubmed.ncbi.nlm.nih.gov/12476793
https://pubmed.ncbi.nlm.nih.gov/12476793
Autor:
N J, Waterhouse, J A, Trapani
Publikováno v:
Tissue antigens. 59(3)
The induction of cell death by cytotoxic T-lymphocytes (CTL) or natural killer (NK) cells is one of the main ways by which higher organisms protect themselves from rogue cells, including those infected by a virus, or posing a risk of cancer. Consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13b8d0e5e5bf6a6ed97c4701bd158796
https://pubmed.ncbi.nlm.nih.gov/12074707
https://pubmed.ncbi.nlm.nih.gov/12074707
Publikováno v:
Journal of leukocyte biology. 70(1)
Cytotoxic lymphocytes largely comprise CD8(+) cytotoxic T cells and natural killer cells and form the major defense of higher organisms against virus-infected and transformed cells. A key function of cytotoxic lymphocytes is to detect and eliminate p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94f9d2c0425fff88ef54efc6f5764f50
https://pubmed.ncbi.nlm.nih.gov/11435481
https://pubmed.ncbi.nlm.nih.gov/11435481
Publikováno v:
European journal of immunology. 31(1)
Recent studies have demonstrated that granzymes A and B make an important contribution to the clearance of the orthopoxvirus ectromelia, and in graft versus host disease. To test whether granzymes are generally necessary for lymphocyte-mediated cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17adf2e92ac95af5eb82d403411611e4
https://pubmed.ncbi.nlm.nih.gov/11169436
https://pubmed.ncbi.nlm.nih.gov/11169436