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Levels of

Autor: E L, Sweeney, E, Trembizki, C, Bletchly, C S, Bradshaw, A, Menon, F, Francis, J, Langton-Lockton, G R, Nimmo, D M, Whiley

Publikováno v: Journal of clinical microbiology. 57(3)

Mycoplasma genitalium is frequently associated with urogenital and rectal infections, with the number of cases of macrolide-resistant and quinolone-resistant M. genitalium infection continuing to increase. In this study, we examined the levels of res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::001ef551d33af5f014a426ec9f987dce
https://pubmed.ncbi.nlm.nih.gov/30602443

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Variability in fasting lipid and glycogen contents in hepatic and skeletal muscle tissue in subjects with and without type 2 diabetes: a 1 H and 13 C MRS study

Autor: E Leverton, Simon M. Poucher, Peter G. Morris, J A Lockton, E. Y. H. Khoo, Jan W. Eriksson, Peter Mansell, Ian A. Macdonald, Mary C. Stephenson, Lars Johansson

Publikováno v: NMR in Biomedicine. 26:1518-1526

The measurement of tissue lipid and glycogen contents and the establishment of normal levels of variability are important when assessing changes caused by pathology or treatment. We measured hepatic and skeletal muscle lipid and glycogen levels using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1d80c2a65d6c9f4c193dd96a3e3bbec
https://doi.org/10.1002/nbm.2985

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Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1

Autor: M. Russell, J. Perrett, J. Plume, P. Norwood, Z. Aherne, J. A. Lockton, G. E. Blakey

Publikováno v: British Journal of Clinical Pharmacology. 57:162-169

Aims The primary objectives of the present study were to establish whether there was a pharmacokinetic or pharmacodynamic interaction between the probe drugs caffeine (CYP1A2), tolbutamide (CYP2C9), debrisoquine (CYP2D6), chlorzoxazone (CYP2E1) and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70bb9474eff1679edd704a8d6f266034
https://doi.org/10.1046/j.1365-2125.2003.01973.x

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Evaluation of a pharmacokinetic interaction between remacemide hydrochloride and phenobarbitone in healthy males

Autor: Mervyn J. Eadie, G. E. Blakey, M. Manun'Ebo, Wayne D. Hooper, J. A. Lockton

Publikováno v: British Journal of Clinical Pharmacology. 51:249-255

Aims To determine whether there is a pharmacokinetic interaction between the antiepileptic drugs remacemide and phenobarbitone. Methods In a group of 12 healthy adult male volunteers, the single dose and steady-state kinetics of remacemide were each

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8846811e7f71a695aad55bbe386c3fc2
https://doi.org/10.1046/j.1365-2125.2001.00338.x

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Variability in fasting lipid and glycogen contents in hepatic and skeletal muscle tissue in subjects with and without type 2 diabetes: a 1H and 13C MRS study

Autor: M C, Stephenson, E, Leverton, E Y H, Khoo, S M, Poucher, L, Johansson, J A, Lockton, J W, Eriksson, P, Mansell, P G, Morris, I A, MacDonald

Publikováno v: NMR in biomedicine. 26(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e3f9e87067248e1c47a58ca1b99338e
https://pubmed.ncbi.nlm.nih.gov/23836451

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Ethnic differences in risk markers for heart disease in Bradford and implications for preventive strategies

Autor: A Bedford, P Sahota, J. A. Lockton, M Toop, Z Smith, T Knight, M. R. Baker, E. Kernohan

Publikováno v: Journal of Epidemiology & Community Health. 47:89-95

OBJECTIVES--To assess and compare the prevalence of established risk markers for ischaemic heart disease in a sample of Asian and non-Asian men and to relate these observations to preventive strategies. SETTING--Two factories in the textile industry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7946a833ceeaf0285d269d5469aa40
https://doi.org/10.1136/jech.47.2.89

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Time taken for safe manual intravenous infusions of up to 100 ml saline to healthy volunteers

Autor: Andrew Hughes, R M Braybrooke, M V Cantarini, G Hooper, J A Lockton

Publikováno v: International Journal Of Pharmaceutical Medicine. 15:227-229

The objective of the study was to determine practical issues associated with rapid intravenous infusion delivery of volumes up to 100 ml. The study was of an open, randomized, three-way crossover design, and was conducted in 20 healthy volunteers. Ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1858220fa6b5c11d8888931150c3f25
https://doi.org/10.2165/00124363-200110000-00009

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Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial

Autor: J. Andrew Lockton, Richard Eastell, Richard D. Finkelman, Glen Clack, Rosemary A. Hannon, Martin Rimmer, Alan Swaisland

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 25(3)

Src is a nonreceptor tyrosine kinase thought to be essential for osteoclast function and bone resorption. We investigated the effect of the orally available Src inhibitor saracatinib (AZD0530) on bone turnover in healthy men. The study was part of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6860ba6ed6ae04990faf7befe83e85ee
https://pubmed.ncbi.nlm.nih.gov/19775203

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