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Elevated levels of WT1 transcripts in bone marrow harvests are associated with a high relapse risk in patients autografted for acute myeloid leukaemia

Autor: Khalid Tobal, Lindsay Frost, J A Liu Yin, D Osborne

Publikováno v: Bone Marrow Transplantation. 36:67-70

Relapse postautograft in acute myeloid leukaemia (AML), may in part arise from leukaemia cells present in the bone marrow (BM) inoculum, and the level of minimal residual disease (MRD) in BM harvests used for autografting may therefore be clinically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4cf68762f7c8acbcc762ba2be92848
https://doi.org/10.1038/sj.bmt.1704992

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Treatment of relapse after allogeneic bone marrow transplantation with reduced intensity conditioning (FLAG ± Ida) and second allogeneic stem cell transplant

Autor: Katy Rezvani, Rachel Pawson, H. G. Prentice, Saad M. B. Rassam, J. A. Liu Yin, Charles Craddock, M. N. Potter, Mamta Garg, P. Theocharous, Mark Lawler

Publikováno v: British Journal of Haematology. 115:622-629

Acute leukaemias in relapse after allogeneic stem cell transplantation (SCT) respond poorly to donor leucocyte infusions (DLI) compared with chronic myeloid leukaemia (CML), at least in part because of faster disease kinetics. Fludarabine-containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8393f89c73cb8e73e0a561402a9d5b64
https://doi.org/10.1046/j.1365-2141.2001.03150.x

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Megakaryopoiesis in vitro in myelodysplastic syndromor and development es and acute myeloid leukaemia: effect of pegylated recombinant human megakaryocyte growth and development factor in combination with other growth factors

Autor: Julie A. Adams, B. D. Harrison, Mark Briggs, A. Hann, M. L. Brereton, J. A. Liu Yin

Publikováno v: British Journal of Haematology. 108:743-746

Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) can stimulate megakaryopoiesis in vitro in some myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) patients. We assessed PEG-rHuMGDF combined with gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fabbcd9ac67190932045044b37fc67a8
https://doi.org/10.1046/j.1365-2141.2000.01916.x

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Molecular quantitation of minimal residual disease in acute myeloid leukemia with t(8;21) can identify patients in durable remission and predict clinical relapse

Autor: M Macheta, Godfrey R Morgenstern, James Chang, P A Evans, J. A. Liu Yin, Khalid Tobal, Gareth J Morgan, Guy S. Lucas, J Newton

Publikováno v: Blood. 95:815-819

One of the most common translocations in acute myeloid leukemia (AML) is the t(8;21), which produces the fusion gene AML1-MTG8. We have developed a sensitive competitive reverse transcriptase-polymerase chain reaction (RT-PCR) assay forAML1-MTG8 tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c20cad9eae1fc0b387494099417373cc
https://doi.org/10.1182/blood.v95.3.815.003k30_815_819

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RT-PCR method with increased sensitivity shows persistence of PML-RARA fusion transcripts in patients in long-term remission of APL

Autor: K Tobal, J A Liu Yin

Publikováno v: Leukemia. 12:1349-1354

RT-PCR methods have been developed, to date, by various groups to amplify the PML-RARA fusion gene produced by the t(15;17) in APL patients. However, these methods lack the necessary sensitivity to detect minimal residual disease (MRD) below the leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aed93fa613f0043e1949cfdcbeac83
https://doi.org/10.1038/sj.leu.2401133

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Expression of AML1/MTG8 transcripts in clonogenic cells grown from bone marrow of patients in remission of acute myeloid leukaemia with t(8;21)

Autor: Khalid Tobal, Melanie J. Saunders, M. L. Brereton, Julie A. Adams, J. A. Liu Yin

Publikováno v: British Journal of Haematology. 99:921-924

Patients in long-term remission of acute myeloid leukaemia (AML) M2 with t(8;21) after chemotherapy, with or without bone marrow transplantation, are known to retain residual cells which express AML1/MTG8 transcripts in bone marrow, detectable by RT-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2431539cbf7db0b31c259aa9ac875834
https://doi.org/10.1046/j.1365-2141.1997.4673271.x

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The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia

Autor: K. Hyde, Julie A. Adams, Robert Burgess, Mark Briggs, J. A. Liu Yin, M. L. Brereton

Publikováno v: British Journal of Haematology. 99:139-146

Mpl ligand is a recently cloned haemopoietic growth factor that stimulates megakaryopoiesis in vitro and in vivo. We describe the in vitro effect of a truncated form of Mpl ligand, recombinant human megakaryocyte growth and development factor (rHuMGD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78b088cb624749ecd582abbdb0451ca
https://doi.org/10.1046/j.1365-2141.1997.3543166.x

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Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission

Autor: Christine J. Harrison, P. R. E. Johnson, J. A. Liu Yin, Melanie J. Saunders, Khalid Tobal

Publikováno v: British Journal of Haematology. 91:104-108

The pericentric inversion of chromosome 16 [inv(16)(p13q22)] and t(16;16)(p13;q22) are chromosomal rearrangements frequently associated with AML FAB type M4Eo resulting in the production of a fusion gene CBFB/MYH11. We studied 17 patients with a chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464108243a36fc56a4792ed208968613
https://doi.org/10.1111/j.1365-2141.1995.tb05253.x

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