Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J A Lavy"'
Autor:
Kobi J. Simpson-Lavy, Martin Kupiec
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105083- (2022)
Summary: Cellular regulation of pH is crucial for internal biological processes and for the import and export of ions and nutrients. In the yeast Saccharomyces cerevisiae, the major proton pump (Pma1) is regulated by glucose. Glucose is also an inhib
Externí odkaz:
https://doaj.org/article/313810acec7647d9b4b58f3e55f2b4b2
Autor:
Kobi J. Simpson-Lavy, Martin Kupiec
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1368
Energy status in all eukaryotic cells is sensed by AMP-kinases. We have previously found that the poly-histidine tract at the N-terminus of S. cerevisiae AMPK (Snf1) inhibits its function in the presence of glucose via a pH-regulated mechanism. We sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8777f00bf990e9a228a1cdba74c09c17
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1865-1875 (2015)
Yeast cells with DNA damage avoid respiration, presumably because products of oxidative metabolism can be harmful to DNA. We show that DNA damage inhibits the activity of the Snf1 (AMP-activated) protein kinase (AMPK), which activates expression of g
Externí odkaz:
https://doaj.org/article/4e0df3dec3fb40df97e868fd44702d8b
Autor:
Kobi J. Simpson-Lavy, Martin Kupiec
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Cells adapt their gene expression and their metabolism in response to a changing environment. Glucose represses expression of genes involved in the catabolism of other carbon sources in a process known as (carbon) catabolite repression. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d573b8165b506cd71301ebf4af98b591
http://link.springer.com/article/10.1038/s41598-019-43032-w
http://link.springer.com/article/10.1038/s41598-019-43032-w
Autor:
Martin Kupiec, Kobi J. Simpson-Lavy
Publikováno v:
Current opinion in cell biology. 69
Many cellular processes involve buffering mechanisms against noise to enhance state stability. Such processes include the cell cycle and the switch between respiration and fermentation. In recent years, protein aggregation/condensation has emerged as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf3896a441da1f2bb78a3b669b1c686
https://pubmed.ncbi.nlm.nih.gov/33388622
https://pubmed.ncbi.nlm.nih.gov/33388622
Autor:
Kobi J Simpson-Lavy, Michael Brandeis
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15089 (2010)
The Swe1/Wee1 kinase phosphorylates and inhibits Cdk1-Clb2 and is a major mitotic switch. Swe1 levels are controlled by ubiquitin mediated degradation, which is regulated by interactions with various mitotic kinases. We have recently reported that Sw
Externí odkaz:
https://doaj.org/article/8ed65a1cefca458d9b1889a50187772c
Autor:
Amir Florentin, Daniela Rotin, Jeremiah Lilly, Martin Kupiec, Maulik N. Thaker, Shira kadosh, Kobi J. Simpson-Lavy, Gali Prag, Anna Shusterman, Alina Kordonsky, Sivan Elias, Bar Manori, Mor Sror, Tal Marshanski, Reut Avishid, Elon Yariv, Victor Tarabykin, Ofir Almog, Olga Levin-Kravets, Mateusz C. Ambrozkiewicz, Nicole Ben David, Sagnik Biswas, Zohar Fischer, Yael Langut, Avinash Persaud, Ekaterina Borisova
Publikováno v:
Journal of Molecular Biology. 433:167276
Split reporter protein-based genetic section systems are widely used to identify and characterize protein–protein interactions (PPI). The assembly of split markers that antagonize toxins, rather than required for synthesis of missing metabolites, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd9b1ae094a85162bdc3220894d7cbb
https://doi.org/10.1016/j.jmb.2021.167276
https://doi.org/10.1016/j.jmb.2021.167276
Autor:
Martin Kupiec, Kobi J. Simpson-Lavy
Publikováno v:
Current genetics. 65(6)
Most organisms prefer to utilize glucose as a carbon source. Accordingly, the expression of genes involved in the catabolism of other carbon sources is repressed by the presence of glucose in a process known as (carbon) catabolite repression. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c93c8ce9b95f9ffb115d1a395d52f2a
https://pubmed.ncbi.nlm.nih.gov/31119370
https://pubmed.ncbi.nlm.nih.gov/31119370
Autor:
Kobi J. Simpson-Lavy, Martin Kupiec
Publikováno v:
Current genetics. 64(4)
Glucose is the preferred carbon of the yeast Saccharomyces cerevisiae. Depletion of glucose activates SNF1 (yeast AMP-activated protein kinase-AMPK), allowing cells to switch from fermentation to respiration. We have recently characterized the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7478f1957d2f0e3c223b4c223cc380e2
https://pubmed.ncbi.nlm.nih.gov/29322248
https://pubmed.ncbi.nlm.nih.gov/29322248
Publikováno v:
Molecular cell. 68(6)
The ability to respond to available nutrients is critical for all living cells. The AMP-activated protein kinase (SNF1 in yeast) is a central regulator of metabolism that is activated when energy is depleted. We found that SNF1 activity in the nucleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2d894367afdb56d98bce49b847aac1
https://pubmed.ncbi.nlm.nih.gov/29272701
https://pubmed.ncbi.nlm.nih.gov/29272701