Výsledky vyhledávání

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells

Autor: Michele Mietus-Snyder, S K Karathanasis, Frances M. Sladek, Jr Je Darnell, J A Ladias, Geoffrey S. Ginsburg, CF Kuo

Publikováno v: Molecular and Cellular Biology. 12:1708-1718

Apolipoprotein CIII (apoCIII), a lipid-binding protein involved in the transport of triglycerides and cholesterol in the plasma, is synthesized primarily in the liver and the intestine. A cis-acting regulatory element, C3P, located at -90 to -66 upst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcc7c58f2d8ff2608cfcd325ff650f5e
https://doi.org/10.1128/mcb.12.4.1708

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Synergistic Interactions between Transcription Factors Control Expression of the Apolipoprotein AI Gene in Liver Cells

Autor: R L, Widom, J A, Ladias, S, Kouidou, S K, Karathanasis

Publikováno v: Molecular and Cellular Biology. 11:677-687

The gene coding for apolipoprotein AI (apoAI), a plasma protein involved in the transport of cholesterol and other lipids in the plasma, is expressed predominantly in liver and intestine. Previous work in our laboratory has shown that different cis-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847b6438cf52c04fa735b7a1fe81603f
https://doi.org/10.1128/mcb.11.2.677-687.1991

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Solution structure of the hRPABC14.4 subunit of human RNA polymerases

Autor: del Río-Portilla F, A, Gaskell, D, Gilbert, J A, Ladias, G, Wagner

Publikováno v: Nature structural biology. 6(11)

The protein hRPABC14.4 is an essential subunit of human RNA polymerases I, II, and III and is required for the transcription of all human nuclear genes. The structure of hRPABC14.4 was determined by nuclear magnetic resonance spectroscopy. The protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0663b2e6849aca27003d7fda9738f3e
https://pubmed.ncbi.nlm.nih.gov/10542096

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Convergence of multiple nuclear receptor signaling pathways onto the long terminal repeat of human immunodeficiency virus-1

Autor: J A, Ladias

Publikováno v: The Journal of biological chemistry. 269(8)

A composite element that interacts with multiple nuclear receptors has been identified in the long terminal repeat (LTR) of the human immunodeficiency virus-1 (HIV-1). This element, designated nuclear receptor-responsive element (NRRE), spans the -35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::987607986bbb252c30246f8554e9c8ab
https://pubmed.ncbi.nlm.nih.gov/8119938

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Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element

Autor: M E, Carter, T, Gulick, B D, Raisher, T, Caira, J A, Ladias, D D, Moore, D P, Kelly

Publikováno v: The Journal of biological chemistry. 268(19)

We have recently identified a complex transcriptional regulatory element in the medium chain acyl-CoA dehydrogenase (MCAD) gene promoter region that confers response to retinoids through interaction with receptors for all-trans-retinoic acid (RARs) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21cdc329458857f57b00841291e8fccb
https://pubmed.ncbi.nlm.nih.gov/8314750

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Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3

Autor: J A, Ladias, M, Hadzopoulou-Cladaras, D, Kardassis, P, Cardot, J, Cheng, V, Zannis, C, Cladaras

Publikováno v: The Journal of biological chemistry. 267(22)

Apolipoproteins B, CIII, and AII are synthesized primarily in the liver and intestine and play an important role in lipid and cholesterol metabolism. It was previously shown that the cis-acting elements (BA1 (-79 to -63), CIIIB (-87 to -63), and AIIJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3979ba2fb1e0eeec03f80ee5a286a698
https://pubmed.ncbi.nlm.nih.gov/1639815

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Apolipoprotein B-100 Hopkins (arginine4019----tryptophan). A new apolipoprotein B-100 variant in a family with premature atherosclerosis and hyperapobetalipoproteinemia

Autor: J A, Ladias, P O, Kwiterovich, H H, Smith, M, Miller, P S, Bachorik, T, Forte, A J, Lusis, S E, Antonarakis

Publikováno v: JAMA. 262(14)

A 43-year-old woman with severe coronary artery disease and hyperapobetalipoproteinemia was heterozygous for an abnormal Msp I apolipoprotein B (APOB) gene fragment because of the absence of the MspI site around codon 4046 in exon 29 of the APOB gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39987184a80b2961912ff2ab7550dc25
https://pubmed.ncbi.nlm.nih.gov/2778934

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Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms

Autor: P O Kwiterovich, C Heinzman, Aldons J. Lusis, J A Ladias, R Bütler, Stylianos E. Antonarakis, Verne N. Schumaker, Y H Ma

Publikováno v: Arteriosclerosis (Dallas, Tex.). 8(5)

Berg et al. (Clin Genet 1986;30:515-520) have reported that an Xba I DNA polymorphic site in exon 26 of the apolipoprotein (apo) B gene is associated both with the Ag(x/y) immunochemical polymorphism and with elevated serum lipoprotein levels. Ma et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e61396a32a50fdd6477a2ae5208205
https://pubmed.ncbi.nlm.nih.gov/2461193

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