Výsledky vyhledávání

Hepatosplenic γδ T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation

Autor: Marc J Kahn, Malek Kamoun, Peter C. Nowell, Kevin E. Salhany, Darren M Wilson, Michael J Feldman, Richard Schretzenmair, J A Kant, David Peritt, Alan D. Glick, Robert S DiPaola

Publikováno v: Human Pathology. 28:674-685

Hepatosplenic gammadelta T cell lymphoma (TCL) is a rare, aggressive subset of peripheral TCL that presents with hepatosplenomegaly and cytopenias. Detailed clinicopathological, ultrastructural, and cytogenetic analyses of these lymphomas are limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7a9cc9df57702d1aa26c793eec2490
https://doi.org/10.1016/s0046-8177(97)90176-3

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Plaque-Associated Neuronal Proteins: A Recurrent Motif in Neuritic Amyloid Deposits throughout Diverse Cortical Areas of the Alzheimer's Disease Brain

Autor: Marie L. Schmidt, John Q. Trojanowski, A. G. Didario, J. A. Kant, N. Hoshi, Laszlo Otvos, Virginia M.-Y. Lee

Publikováno v: Experimental Neurology. 130:311-322

Diffuse and neuritic plaques are sites of accumulation of beta-amyloid peptides (A beta) in the brains of Alzheimer's disease (AD) patients. Although amyloid fibrils are formed from A beta, the contribution of other plaque-associated proteins and pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b664cd006b24c6f8b75a16882b15376c
https://doi.org/10.1006/exnr.1994.1209

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CD28-stimulated IL-2 gene expression in Jurkat T cells occurs in part transcriptionally and is cyclosporine-A sensitive

Autor: T M Williams, D M Moolten, H Makni, H W Kim, J A Kant, M Kamoun

Publikováno v: The Journal of Immunology. 148:2609-2616

CD28 is a glycoprotein expressed as a homodimer on the surface of a major subset of human T cells. Previous studies have shown that proliferation of peripheral blood T cells involving the CD28 pathway is associated with cyclosporine A (CsA) resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67f93336b88a008d18cae6e67c61a151
https://doi.org/10.4049/jimmunol.148.8.2609

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Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis

Autor: E Myers, J A Kant, S.E. Applebaum-Shapiro, Roland H. Pfützer, John P. Neoptolemos, David C. Whitcomb, Ian O. Ellis, Robert Finch

Publikováno v: Gut. 50(2)

Hereditary pancreatitis (HP) is usually caused by mutations in the cationic trypsinogen (PRSS1) gene, especially R122H or N29I. We sequenced the PRSS1 gene in the proband of families without these common mutations. Novel R122C and N29T mutations were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ef8723f3db7fa938f3c7378946674d
https://pubmed.ncbi.nlm.nih.gov/11788572

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Genetic testing. Counseling, laboratory, and regulatory issues and the EUROPAC protocol for ethical research in multicenter studies of inherited pancreatic diseases

Autor: S E, Applebaum, J A, Kant, D C, Whitcomb, I H, Ellis

Publikováno v: The Medical clinics of North America. 84(3)

This article highlights several of the important issues and illustrates a European protocol that should be considered when offering genetic testing on a research or clinical basis for HP, as well as for other inherited disorders of the pancreas.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::baf979c45c6a4d20ce246246cc4aeed3
https://pubmed.ncbi.nlm.nih.gov/10872415

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Rapid diagnosis of herpes simplex encephalitis using microchip electrophoresis of PCR products

Autor: W T, Hofgärtner, A F, Hühmer, J P, Landers, J A, Kant

Publikováno v: Clinical chemistry. 45(12)

Herpes simplex virus (HSV) is the most common cause of acute sporadic encephalitis in the United States. PCR of DNA extracted from cerebrospinal fluid (CSF) allows for reliable diagnosis of herpes simplex encephalitis (HSE). A faster turnaround time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d15f4d69b10d3a44ecaede1278b3d94e
https://pubmed.ncbi.nlm.nih.gov/10585343

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Molecular diagnostics on microfabricated electrophoretic devices: from slab gel- to capillary- to microchip-based assays for T- and B-cell lymphoproliferative disorders

Autor: N J, Munro, K, Snow, J A, Kant, J P, Landers

Publikováno v: Clinical chemistry. 45(11)

Current methods for molecular-based diagnosis of disease rely heavily on modern molecular biology techniques for interrogating the genome for aberrant DNA sequences. These techniques typically include amplification of the target DNA sequences followe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8effaf93e58dd60a832c60d6a5cf45df
https://pubmed.ncbi.nlm.nih.gov/10545059

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