Zobrazeno 1 - 10
of 13
pro vyhledávání: '"J A DeLeo"'
Publikováno v:
Regional Anesthesia and Pain Medicine. 24:557-562
Studies show that pain may cause neuroinflammatory changes in the spinal cord. These inflammatory changes could be caused by circulating factors such as plasma cytokines or could be a primary neuroimmune response of the central nervous system followi
Autor:
R W Colburn, J A DeLeo
Publikováno v:
Brain Research Bulletin. 49:419-427
Factors transported centrally from the site of a peripheral nerve injury are known to provide cellular activation signals to the dorsal root ganglion and spinal cord. Yamamoto and Yaksh [35] were able to use colchicine disruption of axonal transport
Publikováno v:
The Journal of comparative neurology. 439(2)
The specific mechanisms by which nervous system injury becomes a chronic pain state remain undetermined. Historically, it has been believed that injuries proximal or distal to the dorsal root ganglion (DRG) produce distinct pathologies that manifest
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(3)
The present study was undertaken to determine whether propentofylline, a glial modulating agent, could both prevent the induction of mechanical allodynia and attenuate existing mechanical allodynia in a rodent L5 spinal nerve transection model of neu
Autor:
J E, Dayhoff, J M, DeLeo
Publikováno v:
Cancer. 91
Artificial neural networks now are used in many fields. They have become well established as viable, multipurpose, robust computational methodologies with solid theoretic support and with strong potential to be effective in any discipline, especially
Publikováno v:
Brain research. 879(1-2)
Interleukin-6 (IL-6) is a pleiotrophic cytokine with a diverse range of actions including the modulation of the peripheral and central nervous system. We have previously shown significant IL-6 protein and messenger RNA elevation in rat spinal cord fo
Publikováno v:
Clinical chemistry. 45(7)
The clinical accuracy of diagnostic tests commonly is assessed by ROC analysis. ROC plots, however, do not directly incorporate the effect of prevalence or the value of the possible test outcomes on test performance, which are two important factors i
Autor:
Jean-Jacques Hauw, Peter L. Lantos, Kurt A. Jellinger, Ann C. McKee, S. E. Daniel, J. M. DeLeo, Massimo Tabaton, Irene Litvan, Dikran S. Horoupian, Dennis W. Dickson
Publikováno v:
Brain : a journal of neurology. 119
Summary Artificial neural networks (ANNs), computer paradigms that can learn, excel in pattern recognition tasks such as disease diagnosis. Artificial neural networks operate in two different learning modes: supervised, in which a known diagnostic ou
Publikováno v:
Anesthesia and analgesia. 81(3)
The purpose of this study was to evaluate the effects of preemptive and postlesion sympathectomy in the sciatic cryoneurolysis (SCN) model of neuropathic pain in rats. SCN in rats produces a prolonged significant mechanical allodynia (hypersensitivit
Publikováno v:
Anesthesia and analgesia. 81(3)
The purpose of this study was to investigate the possibility that sympathetic exacerbation of neuropathic pain activity may be mediated in part by the development of abnormal peripheral adrenergic mechanisms at the site of peripheral nerve injury. We