Zobrazeno 1 - 10
of 103
pro vyhledávání: '"J A, Verhoef"'
Autor:
B. de Graaf, T. Koster, J. Hoogterp, J. van den Broeke, J. W. Verhoef, E. Trietsch, F. Williamson, M. Klein Koerkamp
Publikováno v:
Water Practice and Technology. 9:575-585
To ensure the safe supply of drinking water, the quality needs to be monitored online in real time. The consequence of inadequate monitoring can result in substantial health risks and economic and reputational damages. Therefore, Vitens, the largest
Autor:
Wim Jiskoot, Anke Huckriede, J. Coos Verhoef, Hans E. Junginger, Laura Bungener, Maryam Amidi, Daan J.A. Crommelin, Stefan Romeijn
Publikováno v:
Vaccine, 25(1), 144-153. ELSEVIER SCI LTD
In this study, the potential of N-trimethyl chitosan (TMC) nanoparticles as a carrier system for the nasal delivery of a monovalent influenza subunit vaccine was investigated. The antigen-loaded nanoparticles were prepared by mixing a solution contai
Publikováno v:
Pharmaceutical Research, 21(5), 799-802. Springer New York
Van Den Berg, M P, Merkus, P, Romeijn, S G, Verhoef, J C & Merkus, F W H M 2004, ' Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery : Studies in rats and comparison with a human study ', Pharmaceutical Research, vol. 21, no. 5, pp. 799-802 . https://doi.org/10.1023/B:PHAM.0000026431.55383.69
Van Den Berg, M P, Merkus, P, Romeijn, S G, Verhoef, J C & Merkus, F W H M 2004, ' Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery : Studies in rats and comparison with a human study ', Pharmaceutical Research, vol. 21, no. 5, pp. 799-802 . https://doi.org/10.1023/B:PHAM.0000026431.55383.69
Purpose. To investigate the possibility of direct transport of melatonin from the nasal cavity into the cerebrospinal fluid (CSF) after nasal administration in rats and to compare the animal results with a human study. Methods. Rats (n = 8) were give
Publikováno v:
International Journal of Pharmaceutics. 269:303-310
The aim of this study was to investigate and modify the potential of drug-delivery systems based on superporous hydrogel (SPH) for improving the intestinal transport of the peptide drug desmopressin in vitro. The swelling properties and mechanical st
Autor:
Barbara Baudner, Giuseppe Del Giudice, Marzia Monica Giuliani, J. Coos Verhoef, Hans E. Junginger, Rino Rappuoli
Publikováno v:
Vaccine. 21:3837-3844
In this paper we evaluated chitosan microparticles as a vaccine delivery system as well as the mucosal adjuvant LTK63, a nontoxic Escherichia coli enterotoxin (LT) mutant for the intranasal immunization with the group C meningococcal conjugated vacci
Autor:
J. Coos Verhoef, Inez M. van der Lubben, Marjan M. Fretz, Coen Beuvery, Hans E. Junginger, Gideon F.A. Kersten
Publikováno v:
Vaccine. 21:1400-1408
In this study, the ability of chitosan microparticles to enhance both the systemic and local immune responses against diphtheria toxoid (DT) after oral and nasal administration in mice was investigated.Firstly, DT was associated to chitosan micropart
Publikováno v:
Journal of Neuroscience Methods. 116:99-107
Drug transport from the nasal cavity to the brain has gained much interest in the last decade. In the present study, a model was developed to determine the uptake of drugs into the cerebrospinal fluid (CSF) after nasal delivery in rats. CSF samples w
Autor:
Morteza Rafiee-Tehrani, Jos H. M. Verheijden, J. Coos Verhoef, Hans E. Junginger, Farid Abedin Dorkoosh, Gerrit Borchard
Publikováno v:
Pharmaceutical Research. 19:1532-1536
Purpose. The aim of this study was to investigate the enhancement of peroral octreotide absorption using delivery systems based on superporous hydrogel (SPH) and SPH composite (SPHC) polymers.
Autor:
Raymond M. Schiffelers, Johan J F Verhoef, Steven de Maat, Ellinor Kenne, Thomas Renné, Coen Maas, Kim Dijkxhoorn, Owen J. T. McCarty, Marcel H.A.M. Fens, Arjan D. Barendrecht, Harry F. G. Heijnen, Antoni P. A. Hendrickx, Katrin F. Nickel, Linda Labberton, Huub Schellekens
Publikováno v:
Blood, 129(12), 1707. American Society of Hematology
Polyphosphate is an inorganic polymer that can potentiate several interactions in the blood coagulation system. Blood platelets contain polyphosphate, and the secretion of platelet-derived polyphosphate has been associated with increased thrombus for
Publikováno v:
Drug delivery and translational research. 3(6)
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade