Zobrazeno 1 - 10
of 27
pro vyhledávání: '"J A, Tischfield"'
Publikováno v:
Cancer research. 60(13)
Heritable gene silencing is an important mechanism of tumor suppressor gene inactivation in a variety of human cancers. In the present study, we show that methylation-associated silencing of the autosomal adenine phosphoribosyltransferase (Aprt) locu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e0b4a9d7fd2598a64f3a77b6e24244a
https://pubmed.ncbi.nlm.nih.gov/10910047
https://pubmed.ncbi.nlm.nih.gov/10910047
Autor:
M S, Turker, B M, Gage, J A, Rose, O N, Ponomareva, J A, Tischfield, P J, Stambrook, C, Barlow, A, Wynshaw-Boris
Publikováno v:
Cancer research. 59(19)
The presence of increased frequencies of blood-derived and solid tumors in ataxia-telangiectasia (A-T) patients, coupled with a role for the ATM (A-T mutation) protein in detecting specific forms of DNA damage, has led to the assumption of a mutator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18f94a27cd23e7fc4dbdfe377ac7a180
https://pubmed.ncbi.nlm.nih.gov/10519383
https://pubmed.ncbi.nlm.nih.gov/10519383
Autor:
M S, Turker, B M, Gage, J A, Rose, D, Elroy, O N, Ponomareva, P J, Stambrook, J A, Tischfield
Publikováno v:
Cancer research. 59(8)
To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5edd60d82e779811ac99fbe3c31bf9f
https://pubmed.ncbi.nlm.nih.gov/10213488
https://pubmed.ncbi.nlm.nih.gov/10213488
Autor:
H J, Edenberg, J, Reynolds, D L, Koller, H, Begleiter, K K, Bucholz, P M, Conneally, R, Crowe, A, Goate, V, Hesselbrock, T K, Li, J I, Nurnberger, B, Porjesz, T, Reich, J P, Rice, M, Schuckit, J A, Tischfield, T, Foroud
Publikováno v:
Alcoholism, clinical and experimental research. 22(5)
A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::841398b2232ac5f0ca0367af02057a65
https://pubmed.ncbi.nlm.nih.gov/9726278
https://pubmed.ncbi.nlm.nih.gov/9726278
Autor:
C R, Cloninger, P, Van Eerdewegh, A, Goate, H J, Edenberg, J, Blangero, V, Hesselbrock, T, Reich, J, Nurnberger, M, Schuckit, B, Porjesz, R, Crowe, J P, Rice, T, Foroud, T R, Przybeck, L, Almasy, K, Bucholz, W, Wu, S, Shears, K, Carr, C, Crose, C, Willig, J, Zhao, J A, Tischfield, T K, Li, P M, Conneally
Publikováno v:
American journal of medical genetics. 81(4)
A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4c9c0913ac65de66c9d2c3a764b797d
https://pubmed.ncbi.nlm.nih.gov/9674977
https://pubmed.ncbi.nlm.nih.gov/9674977
Publikováno v:
The Journal of biological chemistry. 273(23)
We examined the relative contributions of five distinct mammalian phospholipase A2 (PLA2) enzymes (cytosolic PLA2 (cPLA2; type IV), secretory PLA2s (sPLA2s; types IIA, V, and IIC), and Ca2+-independent PLA2 (iPLA2; type VI)) to arachidonic acid (AA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::539f5c8755fd09891353a4cae32599aa
https://pubmed.ncbi.nlm.nih.gov/9603953
https://pubmed.ncbi.nlm.nih.gov/9603953
Autor:
P K, Gupta, A, Sahota, S A, Boyadjiev, S, Bye, C, Shao, J P, O'Neill, T C, Hunter, R J, Albertini, P J, Stambrook, J A, Tischfield
Publikováno v:
Cancer research. 57(6)
We have used the adenine phosphoribosyltransferase gene (APRT; 16q24) to investigate the mechanisms of loss of heterozygosity (LOH) in normal human somatic cells in vivo. APRT-deficient (APRT-/-, APRT-/0) T lymphocytes from the peripheral blood of fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1b5dc1ad5437ca7256a826a60d53c73
https://pubmed.ncbi.nlm.nih.gov/9067291
https://pubmed.ncbi.nlm.nih.gov/9067291
Publikováno v:
Journal of cellular biochemistry. 64(3)
We use in situ hybridization to demonstrate that the testicular expression of a novel, mouse, low molecular weight phospholipase A2 (PLA2 Group IIc) mRNA is specific to cells undergoing meiosis. A complete cDNA (1421 bp) encoding the mouse Pla2g2c ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d383d3053f14a49f5b6bfcd794e101a4
https://pubmed.ncbi.nlm.nih.gov/9057094
https://pubmed.ncbi.nlm.nih.gov/9057094
Autor:
L N, Spirio, W, Kutchera, M V, Winstead, B, Pearson, C, Kaplan, M, Robertson, E, Lawrence, R W, Burt, J A, Tischfield, M F, Leppert, S M, Prescott, R, White
Publikováno v:
Cancer research. 56(5)
Mutation of Pla2g2a, a secretory phospholipase A(2) gene, dramatically increases the number of intestinal polyps that develop in the multiple intestinal neoplasia (Min) mouse, a murine model for adenomatous polyposis coli in humans. We tested the hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4029a4ec8cf4295ce98ec290c2f7959a
https://pubmed.ncbi.nlm.nih.gov/8640784
https://pubmed.ncbi.nlm.nih.gov/8640784
Publikováno v:
Environmental and molecular mutagenesis. 28(4)
We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d959aac58ed2b905deebb130170e7d1e
https://pubmed.ncbi.nlm.nih.gov/8991080
https://pubmed.ncbi.nlm.nih.gov/8991080