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Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta

Autor: J A, Taddie, T R, Hurley, B S, Hardwick, B M, Sefton

Publikováno v: The Journal of biological chemistry. 269(18)

In addition to membrane immunoglobulin (mIg), the B-cell antigen receptor contains Ig-alpha/Ig-beta heterodimers that link mIg to intracellular signaling molecules. To compare the ability of the cytoplasmic domains of Ig-alpha and Ig-beta to transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf4ef4fcaf2bdab209781a74e09bad39
https://pubmed.ncbi.nlm.nih.gov/8175787

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B-cell activation by wild type and mutant Ig-beta cytoplasmic domains

Autor: J A, Taddie, T R, Hurley, B M, Sefton

Publikováno v: Advances in experimental medicine and biology. 365

In B lymphocytes, the cytoplasmic domains of the membrane immunoglobulin-associated heterodimeric Ig-alpha and Ig-beta proteins link membrane immunoglobulin to intracellular signalling molecules. We constructed chimeric genes encoding the extracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29edd110e598e2d23e6b775436cd8080
https://pubmed.ncbi.nlm.nih.gov/7887308

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Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain

Autor: Paula Traktman, J A Taddie

Publikováno v: Journal of virology. 67(7)

In this report, we describe the isolation, molecular genetic mapping, and phenotypic characterization of vaccinia virus mutants resistant to cytosine arabinoside (araC) and phosphonoacetic acid (PAA). At 37 degrees C, 8 microM araC was found to preve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42938a221767974eadff2863e016b170
https://pubmed.ncbi.nlm.nih.gov/8389930

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Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity

Autor: Paula Traktman, J A Taddie

We determined that 85 microM aphidicolin was sufficient to block macroscopic plaque formation by vaccinia virus and to cause a 10(4)-fold reduction in viral yield from a wild-type infection. A chemically mutagenized viral stock was passaged sequentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8200eee70808e6aa27cda0cf99b59b6a
https://europepmc.org/articles/PMC239827/

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