Výsledky vyhledávání - "J A, Swenberg"

Weight of the evidence on the human carcinogenicity of 2,4-D*

Autor: R. S. Greenberg, I. C. Munro, G. G. Bond, E. McConnell, T. A. Burke, S. H. Zahm, M. A. Ibrahim, P. E. Enterline, John D. Graham, M. Gough, Philip A. Cole, F. N. Dost, William E. Halperin, J. A. Swenberg

Publikováno v: Environmental Health Perspectives

The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the human carcinogenicity of 2,4-D. The panel based its fin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153d63aaca5ca3ce3b2f47983e6a2779
http://europepmc.org/articles/PMC1568222

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Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators

Autor: I, Rusyn, S, Yamashina, B H, Segal, R, Schoonhoven, S M, Holland, R C, Cattley, J A, Swenberg, R G, Thurman

Publikováno v: Cancer research. 60(17)

It was shown that 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (Wy-14,643), a potent peroxisome proliferator, caused rapid oxidant-dependent activation of nuclear factor kappaB (NF-kappaB) in Kupffer cells in vivo and activated superoxide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::888275d9ec732c985e68812c5a04ba16
https://pubmed.ncbi.nlm.nih.gov/10987289

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1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism

Autor: J A, Swenberg, N I, Christova-Gueorguieva, P B, Upton, A, Ranasinghe, N, Scheller, K Y, Wu, T Y, Yen, R, Hayes

Publikováno v: Research report (Health Effects Institute). (92)

1,3-Butadiene (BD) is an important chemical used largely in the manufacture of synthetic rubber and thermoplastic resins. In addition, it has been identified in cigarette smoke, automobile exhaust, and gasoline vapor. The objective of this research w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f01acc271ef9061dd8c5d447800f342
https://pubmed.ncbi.nlm.nih.gov/10925842

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Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease

Autor: S P, Hussain, P, Amstad, K, Raja, S, Ambs, M, Nagashima, W P, Bennett, P G, Shields, A J, Ham, J A, Swenberg, A J, Marrogi, C C, Harris

Publikováno v: Cancer research. 60(13)

Ulcerative colitis (UC) is a chronic inflammatory disease that produces reactive oxygen and nitrogen species and increases the risk of colorectal cancer (CRC). The p53 tumor suppressor gene is frequently mutated in UC-associated dysplastic lesions an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6daaac03b4236fc97540deef1c8b0f5f
https://pubmed.ncbi.nlm.nih.gov/10910033

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Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis

Autor: J A, Swenberg, M S, Bogdanffy, A, Ham, S, Holt, A, Kim, E J, Morinello, A, Ranasinghe, N, Scheller, P B, Upton

Publikováno v: IARC scientific publications. (150)

Vinyl chloride is a known human and animal carcinogen that induces angiosarcomas of the liver. We review here studies on the formation and repair of DNA adducts associated with vinyl chloride and vinyl fluoride in exposed and control rodents and unex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d576d717a350960a5c79c84dbeb42064
https://pubmed.ncbi.nlm.nih.gov/10626206

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Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues

Autor: J, Nakamura, J A, Swenberg

Publikováno v: Cancer research. 59(11)

Apurinic/apyrimidinic (AP) sites are one of the most frequent lesions in DNA. Using a highly sensitive slot blot assay, we determined the number and condition of endogenous AP sites in normal tissues of rats and human liver. The number of AP sites (5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdf09f73a8cf5cf834b98d5ae08a2e21
https://pubmed.ncbi.nlm.nih.gov/10363965

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