Zobrazeno 1 - 10
of 39
pro vyhledávání: '"J A, Straw"'
Autor:
J M, Covey, J A, Straw
Publikováno v:
Pharmaceutical research. 2(5)
The kinetic behavior of thymine and 5-fluorouracil has been shown to be non-linear and mediated largely by saturable metabolic processes. In vivo estimates of the Michaelis-Menten parameters Vmax and Km were obtained from constant infusion data in no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af64e046b0b0b927a8a9ad3e14b8508b
https://pubmed.ncbi.nlm.nih.gov/24272838
https://pubmed.ncbi.nlm.nih.gov/24272838
Publikováno v:
Journal of acquired immune deficiency syndromes. 5(9)
The pharmacokinetics of thiophosphonoformate (TPFA) and phosphonoformate (foscarnet, PFA) were studied in normal adult cats, a species susceptible to feline immunodeficiency virus (FIV) infection. Parent drugs and metabolites were quantitated by high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88c2e777d1698d416382c849fd7e61d5
https://pubmed.ncbi.nlm.nih.gov/1387417
https://pubmed.ncbi.nlm.nih.gov/1387417
Publikováno v:
Cancer research. 50(6)
Previous results have suggested that methotrexate (MTX) could interfere with the repair of spontaneous DNA damage. To determine its effects on induced DNA damage, MTX was compared to hydroxyurea and arabinofuranosylcytosine (H/A), a drug combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01e7d97e31c98338b4cd513c9ddd091e
https://pubmed.ncbi.nlm.nih.gov/2306730
https://pubmed.ncbi.nlm.nih.gov/2306730
Publikováno v:
JNCI: Journal of the National Cancer Institute. 58:91-97
Thymidine, in the absence of hypoxanthine, failed to protect normal mice from the acute toxicity of methotrexate, though tumor-bearing animals could be protected with thymidine alone, probably as a result of the availability of DNA degradation produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f49bb0cf3787840991c4a151f57543
https://doi.org/10.1093/jnci/58.1.91
https://doi.org/10.1093/jnci/58.1.91
Publikováno v:
Endocrinology. 77:777-784
Dietary administration of the antithyroid drug, propylthiouracil (PTU), to rats for 20 weeks reduced rate of secretion of aldosterone 26% (mμg/min/adrenal/100 g body wt) to 69% (mμg/min/adrenal) below that of euthyroid controls. Reduction in rate o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b50874898dc83d96db2b6d51e0444f
https://doi.org/10.1210/endo-77-5-777
https://doi.org/10.1210/endo-77-5-777
Autor:
J A Straw
Publikováno v:
Journal of Applied Physiology. 27:630-633
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a1426bbd3af8630ede356646415a4d
https://doi.org/10.1152/jappl.1969.27.5.630
https://doi.org/10.1152/jappl.1969.27.5.630
Publikováno v:
Academic Medicine. 46:69-77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d330b1e0814a647b79b3da5f348cd868
https://doi.org/10.1097/00001888-197101000-00009
https://doi.org/10.1097/00001888-197101000-00009
Publikováno v:
Journal of the National Cancer Institute. 52(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98220ab9b110b86ec3a63e4056499a0f
https://pubmed.ncbi.nlm.nih.gov/4406459
https://pubmed.ncbi.nlm.nih.gov/4406459
Autor:
F, Martz, J A, Straw
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 8(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84cc5a24d36f5fde8d5c832e4087578a
https://pubmed.ncbi.nlm.nih.gov/6104572
https://pubmed.ncbi.nlm.nih.gov/6104572
Publikováno v:
Cancer research. 41(10)
The pharmacokinetics of d- and l-citrovorum factor (CF) are quite different with respect to the postdistributional plasma decay rates. The natural (l) isomer had a half-life (beta) of 47 +/- 4 (S.E.) min compared to 143 +/- 15 min for the unnatural (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc45f60a2e4c4e02a8df5f49403a7bd7
https://pubmed.ncbi.nlm.nih.gov/6974592
https://pubmed.ncbi.nlm.nih.gov/6974592