Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J A, Schuurkes"'
Publikováno v:
British journal of pharmacology. 134(6)
1. We aimed to characterize the 5-HT receptors involved in the 5-HT-induced effect on electrically induced contractions of dog antrum longitudinal muscle in vitro. 2. In the presence of L-NOARG (0.1 mM), electrical field stimulation (EFS) induced atr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5eb48f85972825f3f264dccbf5b999f8
https://pubmed.ncbi.nlm.nih.gov/11704657
https://pubmed.ncbi.nlm.nih.gov/11704657
Publikováno v:
British journal of pharmacology. 131(5)
5-HT(4) receptors mediate circular muscle relaxation in both human and canine large intestine, but this phenomenon alone can not explain the improvement in colonic motility induced by selective 5-HT(4) receptor agonists in vivo. We set out to charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f05d4f7c924442e2f939e7f301a2b08
https://pubmed.ncbi.nlm.nih.gov/11053213
https://pubmed.ncbi.nlm.nih.gov/11053213
Autor:
N H, Prins, N P, Shankley, N J, Welsh, M R, Briejer, R A, Lefebvre, L M, Akkermans, J A, Schuurkes
Publikováno v:
British journal of pharmacology. 129(8)
Recently, it was demonstrated that 5-HT induces relaxation of human colon circular muscle through activation of 5-HT(4) receptors and 5-HT(7) receptors. The aim of the current study was to develop a new in vitro bioassay of human colon that would fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b608e936072049db349f74872e023260
https://pubmed.ncbi.nlm.nih.gov/10780964
https://pubmed.ncbi.nlm.nih.gov/10780964
Publikováno v:
British journal of pharmacology. 128(4)
5-HT4 receptors mediate relaxation of human colon circular muscle. However, after 5-HT4 receptor blockade (SB 204070 10 nM), 5-HT still induced a relaxation (pEC50 6.3). 5-HT4 receptors were sufficiently blocked, as the curves to 5-HT obtained in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::148bfea14ddf737f9a67758207d85a83
https://pubmed.ncbi.nlm.nih.gov/10556917
https://pubmed.ncbi.nlm.nih.gov/10556917
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(2)
The effects of xenin 25, a peptide of the neurotensin/xenopsin family, were examined on the motility of the guinea pig jejunum and colon in vitro. In the jejunum, xenin induced a biphasic response: first a small relaxation and then a large contractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0550221ffbb10f4f3103a265fb9cf510
https://pubmed.ncbi.nlm.nih.gov/8768716
https://pubmed.ncbi.nlm.nih.gov/8768716
Publikováno v:
Pharmacological reviews. 47(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1be755d08b1acc42f0f0b66fc3b1cc97
https://pubmed.ncbi.nlm.nih.gov/8746557
https://pubmed.ncbi.nlm.nih.gov/8746557
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(2)
In the guinea pig proximal colon, 5-hydroxytryptamine (5-HT) stimulates neuronal 5-HT1-like receptors to induce relaxations that are mediated by nitric oxide and ATP. In the current study, the effects of cisapride and structural analogs on these 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f606145554c4cc805da96d8eccbaaf0e
https://pubmed.ncbi.nlm.nih.gov/7636723
https://pubmed.ncbi.nlm.nih.gov/7636723
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 329(1)
The motor effects of 5-hydroxytryptamine (5-HT; serotonin) on the guinea-pig isolated proximal colon were studied and analyzed. A classical organ bath setup was used to measure the longitudinal muscle responses isotonically. 5-Hydroxytryptamine induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::255b172aa9fc8b7797b37447f7af77a8
https://pubmed.ncbi.nlm.nih.gov/7639614
https://pubmed.ncbi.nlm.nih.gov/7639614
Autor:
J A, Schuurkes
Publikováno v:
Revista de gastroenterologia de Mexico. 59(2)
Pharmacotherapy of gastrointestinal motor disorders is complicated by the large variety of drug targets and their interactions, the complex relation between contractile patterns and propulsion and the occurrence of regional and species differences. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38ac918283499a0bfd438b50da65867e
https://pubmed.ncbi.nlm.nih.gov/7991970
https://pubmed.ncbi.nlm.nih.gov/7991970
Autor:
W J, de Ridder, J A, Schuurkes
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 264(1)
Prokinetic benzamides (e.g., cisapride) enhance gastrointestinal motility and transit. In vitro studies on the guinea pig ileum suggest that their effect is mediated via serotonergic 5-hydroxytryptamine (5-HT4) receptors, resulting in a facilitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d47c1cd4bb5605993477db5aef73de5
https://pubmed.ncbi.nlm.nih.gov/8093733
https://pubmed.ncbi.nlm.nih.gov/8093733