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Identification of urinary metabolites of 8-methyl-8-azabicyclo-[3,2,1] octan-3-yl 3,5-dichlorobenzoate (MDL 72,222) in the dog and monkey

Autor: W P, Gordon, H, Cheng, D L, Larsen, J A, Ragner, N G, Landmesser

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(4)

The metabolism of 8-methyl-8-azabicyclo- 3,2,1]octan-3-yl 3,5-dichlorobenzoate (MDL 72,222) was studied in the dog and monkey. Four urinary metabolites were detected by HPLC, HPLC/MS, and GC/MS, and were identified by comparison to authentic standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42980b862fea3f4e9243de2263e31525
https://pubmed.ncbi.nlm.nih.gov/1356741

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Gas chromatographic-mass spectrometric (GC-MS) determination of MDL 72,222 and four metabolites in monkey plasma

Autor: H Y, Cheng, J A, Ragner

Publikováno v: Pharmaceutical research. 8(7)

MDL 72,222 a potent serotonin antagonist, is being developed for use as an antiemetic drug in cancer chemotherapy. An assay method has been developed for the determination of MDL 72,222 and four metabolites: N-desmethyl-MDL 72,222 (1), 3,5-dichlorobe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cad9c7abf651b1430bf7b4e8b4f803f
https://pubmed.ncbi.nlm.nih.gov/1924132

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