Výsledky vyhledávání - "J A, Oppermann"

Characterization of the highly variable bioavailability of tiludronate in normal volunteers using population pharmacokinetic methodologies

Autor: P. Bauer, J. A. Oppermann, G. F. Lockwood, G. Wei, T. Grasela, J. Fedler-Kelly, G. A. Maier

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 24:249-254

Currently, the use of classical bioequivalence criteria is being called into question for certain classes of drugs such as bisphosphonates. These compounds typically possess a wide therapeutic index but may be characterized by low and variable absorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454a0e9395bb0a42990f4b858a7ff03e
https://doi.org/10.1007/bf03190028

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An approach for widening the bioequivalence acceptance limits in the case of highly variable drugs

Autor: A W, Boddy, F C, Snikeris, R O, Kringle, G C, Wei, J A, Oppermann, K K, Midha

Publikováno v: Pharmaceutical research. 12(12)

Highly variable drugs pose a problem in bioequivalence assessment because they often fail to meet current regulatory acceptance criteria for average bioequivalence (80-125%). This paper examines alternative approaches to establishing bioequivalence.S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13232d7dcfb75dedbc3b9ef214a02a43
https://pubmed.ncbi.nlm.nih.gov/8786957

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Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite

Autor: C S, Cook, C, Hauswald, J A, Oppermann, G L, Schoenhard

Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(1)

In vitro metabolism studies of potassium canrenoate (PC) were conducted to examine whether spironolactone (SP) and/or its sulfur-containing metabolites inhibit the PC metabolic pathways to mutagenic metabolites and to elucidate the mechanism for any

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e3481b9b3a5319e89299f49fac2eb49
https://pubmed.ncbi.nlm.nih.gov/8331551

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A review of the metabolism of the aspartyl moiety of aspartame in experimental animals and man

Autor: R E, Ranney, J A, Oppermann

Publikováno v: Journal of environmental pathology and toxicology. 2(4)

Aspartame (3-amino-N-(alpha-carboxyphenethyl) succinamic acid, methyl ester; the methyl ester of aspartylphenylalanine, SC-18862) is hydrolyzed in the gut to yield aspartic acid, phenylalanine, and methanol. This review of the literature describes th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0e933dcdd4a0af31144a2986935833e
https://pubmed.ncbi.nlm.nih.gov/376770

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The metabolism of aspartate in infant and adult mice

Autor: J A, Oppermann, R E, Ranney

Publikováno v: Journal of environmental pathology and toxicology. 2(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d35fb10ce49e4c06d2dad634331eae7d
https://pubmed.ncbi.nlm.nih.gov/448259

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[Disclosing agent influence on microorganisms' quantity in dental plaque]

Autor: J O, Oppermann RV Santos, L C, Tovo

Publikováno v: Revista da Faculdade de Odontologia, Porto Alegre.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37f173b9b831d84974446c355a77f8c1
https://pubmed.ncbi.nlm.nih.gov/5293669

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