Zobrazeno 1 - 10 of 16 pro vyhledávání: '"J A, Moscow"'
1
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients
Autor: K H, Cowan, J A, Moscow, H, Huang, J A, Zujewski, J, O'Shaughnessy, B, Sorrentino, K, Hines, C, Carter, E, Schneider, G, Cusack, M, Noone, C, Dunbar, S, Steinberg, W, Wilson, B, Goldspiel, E J, Read, S F, Leitman, K, McDonagh, C, Chow, A, Abati, Y, Chiang, Y N, Chang, M M, Gottesman, I, Pastan, A, Nienhuis
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(7)
The MDR1 multidrug resistance gene confers resistance to natural-product anticancer drugs including paclitaxel. We conducted a clinical gene therapy study to determine whether retroviral-mediated transfer of MDR1 in human hematopoietic cells would re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0ebe650c8ae1f680aa5ab4d96cdf090
https://pubmed.ncbi.nlm.nih.gov/10430058
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2
Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy
Autor: J A, Moscow, H, Huang, C, Carter, K, Hines, J, Zujewski, G, Cusack, C, Chow, D, Venzon, B, Sorrentino, Y, Chiang, B, Goldspiel, S, Leitman, E J, Read, A, Abati, M M, Gottesman, I, Pastan, S, Sellers, C, Dunbar, K H, Cowan
Publikováno v: Blood. 94(1)
To determine whether the multidrug resistance gene MDR1 could act as a selectable marker in human subjects, we studied engraftment of peripheral blood progenitor cells (PBPCs) transduced with either MDR1 or the bacterial NeoR gene in six breast cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f335ce380cb77e496fdda28440c0d3b
https://pubmed.ncbi.nlm.nih.gov/10381498
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3
Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines
Autor: J A, Moscow, T, Connolly, T G, Myers, C C, Cheng, K, Paull, K H, Cowan
Publikováno v: International journal of cancer. 72(1)
Methotrexate transport deficiency due to decreased reduced folate carrier (RFC) activity has been observed in several cell lines selected for resistance to methotrexate (MTX). Since MTX resistance is multifactorial, however, it is difficult to quanti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f273a0f4c578b9a32fbaa99d168fd40
https://pubmed.ncbi.nlm.nih.gov/9212241
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4
Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line
Autor: M, Gong, J, Yess, T, Connolly, S P, Ivy, T, Ohnuma, K H, Cowan, J A, Moscow
Publikováno v: Blood. 89(7)
Ohnuma et al reported a series of methotrexate-resistant MOLT-3 human T-cell acute lymphoblastic leukemia cell lines that showed decreasing methotrexate (MTX) uptake as the sublines acquired increasing MTX resistance (Cancer Res 45:1815, 1985). The a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c8a0f2d02bc2dad97b681c17651e029
https://pubmed.ncbi.nlm.nih.gov/9116294
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6
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
Autor: J A, Moscow, M, Gong, R, He, M K, Sgagias, K H, Dixon, S L, Anzick, P S, Meltzer, K H, Cowan
Publikováno v: Cancer research. 55(17)
Our laboratory has previously reported the isolation of a murine cDNA which restores reduced folate carrier (RFC) activity and methotrexate (MTX) sensitivity to a MTX-resistant, transport-deficient human breast cancer cell line (MTXR ZR-75-1) (K. H.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67c4d49acd2fb874d74e5718c1e700c6
https://pubmed.ncbi.nlm.nih.gov/7641195
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8
Examination of human tumors for rhoA mutations
Autor: J A, Moscow, R, He, J R, Gnarra, T, Knutsen, Y, Weng, W P, Zhao, J, Whang-Peng, W M, Linehan, K H, Cowan
Publikováno v: Oncogene. 9(1)
rhoA encodes a ras-related GTP-binding protein that is thought to play a role in cytoskeletal organization. Recent evidence has suggested both that rhoA could act either as a dominant oncogene, since transfection of both normal and activated rho gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49271cf184c469c3627fdeb6373e2590
https://pubmed.ncbi.nlm.nih.gov/8302578
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9
Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1)
Autor: J A, Moscow, C S, Morrow, R, He, G T, Mullenbach, K H, Cowan
Publikováno v: The Journal of biological chemistry. 267(9)
Human selenium-dependent glutathione peroxidase (hGPx1) (EC 1.11.1.9) is thought to be involved in many critical cellular functions as a result of its role in glutathione-mediated reduction of toxic peroxides, and it is implicated as a mechanism of r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c211dde531dd1dbe1662c4ed5e3a5ab4
https://pubmed.ncbi.nlm.nih.gov/1556108
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10
Multidrug resistance
Autor: J A, Moscow, K H, Cowan
Publikováno v: Cancer chemotherapy and biological response modifiers. 12
The ability of malignant cells to develop resistance to cytotoxic drugs poses a major obstacle to the ultimate success of cancer therapy. While some mechanisms of resistance allow cells to survive exposure to a single agent, the phenomenon of multidr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e24f144a96ed7f7e8c5f0dccb2ce33f2
https://pubmed.ncbi.nlm.nih.gov/1681846
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