Zobrazeno 1 - 10
of 29
pro vyhledávání: '"J A, Menius"'
Autor:
Christine M. Hunt, Xiwu Lin, Lloyd Curtis, Kwan R. Lee, J. Alan Menius, Jie Cheng, Colin F. Spraggs, Jeffery L. Painter, Jeanenne J. Nelson, Daniel Parks
Publikováno v:
Pharmacoepidemiology and Drug Safety. 22:571-578
Purpose Identifying drug-induced liver injury is a critical task in drug development and postapproval real-world care. Severe liver injury is identified by the liver chemistry threshold of alanine aminotransferase (ALT) >3× upper limit of normal (UL
Publikováno v:
Statistics in Biopharmaceutical Research. 3:506-514
Recent analysis of microarray data has focused on identifying groups of genes that show statistically significant changes in their expression activity. Using annotation databases, genes are grouped into predefined sets based on common characteristics
Autor:
J. Alan Menius, Matthew D. Rousculp
Publikováno v:
North Carolina Medical Journal. 75:188-190
A health care ecosystem is evolving in which all stakeholders will need to work together, apply new technologies, and use disparate data sources to gain insights, increase efficiencies, and improve patient outcomes. The pharmaceutical industry is lev
Autor:
David L. Saussy, J. Alan Menius, Tony D. Choi, Michael W. Lutz, Aaron S. Goetz, Paul L. Domanico, Rebecca Gooding Laskody
Publikováno v:
Drug Discovery Today. 1:277-286
Novel methods in molecular biology and advanced technologies have given pharmaceutical research laboratories the capability to test combinatorial libraries rapidly against large numbers of potential targets. Methods to identify optimal assay conditio
Autor:
Stephen A. Stimpson, R H Brown, J A Wakefield, Brian Edward Marron, James G. Conway, J J Jeffreys, L Sekut, R L Clark, J. A. Menius, A McElroy
Publikováno v:
The Journal of Experimental Medicine
Considerable evidence has associated the expression of matrix metalloproteinases (MMPs) with the degradation of cartilage and bone in chronic conditions such as arthritis. Direct evaluation of MMPs' role in vivo has awaited the development of MMP inh
Autor:
Daniel, Parks, Xiwu, Lin, Jeffery L, Painter, Jie, Cheng, Christine M, Hunt, Colin F, Spraggs, Jeanenne J, Nelson, Lloyd, Curtis, J Alan, Menius, Kwan R, Lee
Publikováno v:
Pharmacoepidemiology and drug safety. 22(6)
Identifying drug-induced liver injury is a critical task in drug development and postapproval real-world care. Severe liver injury is identified by the liver chemistry threshold of alanine aminotransferase (ALT)3× upper limit of normal (ULN) and bil
Publikováno v:
Bioinformatics (Oxford, England). 23(10)
Motivation: New biological systems technologies give scientists the ability to measure thousands of bio-molecules including genes, proteins, lipids and metabolites. We use domain knowledge, e.g. the Gene Ontology, to guide analysis of such data. By f
Autor:
W O Oliver, Derek J. Parks, S A Noble, Brad R. Henke, Jürgen M. Lehmann, J A Menius, W W Harrington, Timothy M. Willson, Kelli D. Plunket, Cobb Jeffrey Edmond, Jane G Binz, K Adkison, Steven G. Blanchard, W.Q. Tong, Robert A. Mook, P J Novak, Steve A. Kliewer, Istvan Kaldor, Kathleen K. Brown, Mir Hashim, W Faison, H. R. Brown, James M. Lenhard
Publikováno v:
Diabetes. 48(7)
The discovery that peroxisome proliferator-activated receptor (PPAR)-gamma was the molecular target of the thiazolidinedione class of antidiabetic agents suggested a key role for PPAR-gamma in the regulation of carbohydrate and lipid metabolism. Thro
Autor:
Michael W. Lutz, Paul H. Morgan, Mauro Corsi, Terrence Peter Kenakin, J. Alan Menius, Charu Krishnamoorthy, Thomas J. Rimele
Publikováno v:
Journal of pharmacological and toxicological methods. 34(1)
Estimates of variance in pharmacological assays are usually made by repeating the experiment with different tissues. Biological factors, such as the inability to wash a drug from tissue, may preclude the type of replication that is appropriate for th
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(3)
We compared the effects of intraperitoneally administered LiCl (0.5-2830 mumol/kg), sulfated cholecystokinin26-33 (10-1000 nmol/kg; CCK-8), nonsulfated CCK-8 (500 and 1000 nmol/kg), sulfated CCK26-29 (500 and 1000 nmol/kg), CCK30-33 (10-1000 nmol/kg)