Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Autor: Heidi Gytz Olesen, Iliana Michailidou, Wioleta M. Zelek, Jeroen Vreijling, Patrick Ruizendaal, Ferry de Klein, J. Arnoud Marquart, Thomas B. Kuipers, Hailiang Mei, Yuchun Zhang, Muhammad Ahasan, Krista K. Johnson, Yi Wang, B. Paul Morgan, Marcus van Dijk, Kees Fluiter, Gregers Rom Andersen, Frank Baas

Publikováno v: Journal of Innate Immunity, Pp 1-21 (2022)

Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervo

Externí odkaz: https://doaj.org/article/0e442cc37f3a4aea9f80cb6df7a3253b

Thrombin activation of the factor XI dimer is a multi-staged process for each subunit

Autor: Awital Bar Barroeta, Pascal Albanese, J. Arnoud Marquart, Joost C.M. Meijers, Richard A. Scheltema

Factor XI (FXI), a protein in the intrinsic coagulation pathway, can be activated by two enzymes. In hemostasis, FXI is activated by thrombin, while FXIIa-mediated activation is prothrombotic. The interactions between FXI and its activating enzymes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a454a6b3d12641da3a3206366f78abc
https://doi.org/10.1101/2023.02.11.528103

A FRET-based assay for the quantitation of the thrombin-factor XI interaction

Autor: Awital Bar Barroeta, J. Arnoud Marquart, Joost C.M. Meijers

Publikováno v: Thrombosis research, 214, 23-28. Elsevier Limited

Background: Thrombin-mediated activation of FXI supports clot stability and protects the clot from fibrinolysis. This generally poor activation could be enhanced to stimulate coagulation, which might serve patients experiencing bleeding, for example

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcca00cc5bcd1d7aca62ad01efb7836
https://pubmed.ncbi.nlm.nih.gov/35452868

Factor Xa Activation of Factor V Is of Paramount Importance in Initiating the Coagulation System: Lessons From a Tick Salivary Protein

Autor: Matthew W. Bunce, Kamran Bakhtiari, Rodney M. Camire, Erol Fikrig, Gerry A. F. Nicolaes, Tim J. Schuijt, Tom van der Poll, Simone J.H. Wielders, Joppe W. Hovius, Kathleen DePonte, J. Arnoud Marquart, Cornelis van 't Veer, Sirlei Daffre, Joost C. M. Meijers

Publikováno v: Circulation, 128(3), 254-266. Lippincott Williams and Wilkins
Circulation, 128(3), 254-266. LIPPINCOTT WILLIAMS & WILKINS
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background— Generation of active procoagulant cofactor factor Va (FVa) and its subsequent association with the enzyme activated factor X (FXa) to form the prothrombinase complex is a pivotal initial event in blood coagulation and has been the subje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d1f2b36c4edf2c5b4ad20402710c7
https://doi.org/10.1161/circulationaha.113.003191

The Design and Characterization of Receptor-selective APRIL Variants

Autor: Marco Guadagnoli, Luis Serrano, Almer M. van der Sloot, J. Arnoud Marquart, Fiona C. Kimberley, Kate Cameron, Miranda Versloot, Pascal Schneider, Jan Paul Medema

Publikováno v: Journal of biological chemistry, 287(44), 37434-37446. American Society for Biochemistry and Molecular Biology Inc.
J Biol Chem

A proliferation-inducing ligand (APRIL), a member of the TNF ligand superfamily with an important role in humoral immunity, is also implicated in several cancers as a prosurvival factor. APRIL binds two different TNF receptors, B cell maturation anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329a5a276a8f7e92edab30d9a45dc832
https://doi.org/10.1074/jbc.m112.406090