Zobrazeno 1 - 10
of 21
pro vyhledávání: '"J A, Kepler"'
Publikováno v:
Organic letters. 3(7)
[structure: see text]. Replacing the 17alpha-acetoxy substituent in an antiprogestational 17beta-acetyl-11beta-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor binding with little effect on progestin recept
Autor:
Y, Zhan, A M, Saindane, U, Scheffel, F I, Carroll, C R, Holmquist, J A, Kepler, G F, Taylor, M J, Kuhar
Publikováno v:
Synapse (New York, N.Y.). 25(4)
Publikováno v:
Cancer research. 56(19)
The antimitotic depsipeptide cryptophycin 1 (CP1) was compared to the antimitotic peptide dolastatin 10 (D10) as an antiproliferative agent and in its interactions with purified tubulin. The potent activity of CP1 as an inhibitor of cell growth was c
Publikováno v:
Molecular pharmacology. 47(5)
We have prepared [3H]dolastatin 10 and examined its interactions with tubulin. Binding kinetics appeared to be biphasic, with a rapid initial reaction that could not be accurately measured, followed by a slower second reaction. Bound drug was stable
Autor:
J. S. Kepler
Publikováno v:
The Mariner's Mirror. 65:265-268
Autor:
J. S. Kepler
Publikováno v:
Business History. 17:44-55
Publikováno v:
Journal of Heterocyclic Chemistry. 4:262-267
The syntheses of several 5-substituted benzimidazoles structurally related to the highly active analgesic 1-(β-diethylaminoethyl)-2-(p-ethoxybenzyl)-5-nitrobenzimidazole are presented.
Autor:
J. S. Kepler
Publikováno v:
The Mariner's Mirror. 59:218-221
Autor:
F. I. Carroll, J. A. Kepler
Publikováno v:
Canadian Journal of Chemistry. 44:2909-2912
Chlorination of 1-nitroalkenes in acetic acid at 0° in the presence of hydrogen chloride gives the corresponding 1,2-dichloro-1-nitroalkanes in good yields. If the reaction is carried out at higher temperatures, an α-chlorohydroxamoyl chloride, res