Zobrazeno 1 - 7
of 7
pro vyhledávání: '"J A, Javitch"'
Publikováno v:
Journal of neurochemistry. 77(2)
The antipsychotic drugs have been shown to be inverse agonists at the D(2) dopamine receptor. We have examined the mechanism of this inverse agonism by making mutations in residue T343 in the base of the sixth transmembrane spanning region of the rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a0b464255af607a432d2ce4ffe34935
https://pubmed.ncbi.nlm.nih.gov/11299312
https://pubmed.ncbi.nlm.nih.gov/11299312
Publikováno v:
Journal of neurochemistry. 76(4)
There is evidence to suggest that dopamine (DA) oxidizes to form dopamine ortho-quinone (DAQ), which binds covalently to nucleophilic sulfhydryl groups on protein cysteinyl residues. This reaction has been shown to inhibit dopamine uptake, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4ab04fa7e70b0671a22eb3a933447fe
https://pubmed.ncbi.nlm.nih.gov/11181843
https://pubmed.ncbi.nlm.nih.gov/11181843
Publikováno v:
The Journal of biological chemistry. 275(48)
Previous work in the beta(2)-adrenergic receptor demonstrated critical interactions between Ser-204 and Ser-207 in the fifth membrane-spanning segment and the meta-OH and para-OH, respectively, of catecholamine agonists (Strader, C. D., Candelore, M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf2b7eaeb76ed9f6ab7c43876cacbc78
https://pubmed.ncbi.nlm.nih.gov/10964911
https://pubmed.ncbi.nlm.nih.gov/10964911
Autor:
J A, Javitch
Publikováno v:
Methods in enzymology. 296
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b7e0d72493a64ba130e6084ac0679cd
https://pubmed.ncbi.nlm.nih.gov/9779459
https://pubmed.ncbi.nlm.nih.gov/9779459
Publikováno v:
The Journal of clinical psychiatry. 52(11)
Hypochondriasis is a disorder for which there are no established effective treatments. Hypochondriacs, in their obsessions about illness, compulsions to check with others, and failure to be reassured, share many features in common with those who have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::071525ac2d14874e71d82a8c96fcd1e0
https://pubmed.ncbi.nlm.nih.gov/8509353
https://pubmed.ncbi.nlm.nih.gov/8509353
Publikováno v:
Molecular pharmacology. 23(3)
With appropriate measures to protect 3H-substance P (3H-SP) from proteolytic degradation and from nonspecific adsorption to glass-fiber filters, we have been able to demonstrate reliably a high-affinity specific binding of 3H-SP to rat submaxillary/s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62b77c7ab7b852b85a9b86b908d771f3
https://pubmed.ncbi.nlm.nih.gov/6191191
https://pubmed.ncbi.nlm.nih.gov/6191191
Publikováno v:
Molecular pharmacology. 26(1)
[3H]Mazindol labels neuronal dopamine uptake sites in corpus striatum membranes (KD = 18 nM) and neuronal norepinephrine uptake sites in cerebral cortex and submaxillary/sublingual gland membranes (KD = 4 nM). The potencies of various inhibitors of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5997f3c341d286b49064d3f371812be6
https://pubmed.ncbi.nlm.nih.gov/6087116
https://pubmed.ncbi.nlm.nih.gov/6087116