Zobrazeno 1 - 10 of 27 pro vyhledávání: '"J A, Heddle"'
1
New approaches to antimutagenesis
Autor: J A, Heddle, J, Moody, L U, Thompson, D K, Torous, G, Trentin
Publikováno v: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 18(2)
One of the most worrisome possibilities in the field of antimutagenesis and anticarcinogenesis is that factors that protect against one mutagen or carcinogen will not be effective against another. Indeed, such specificities are known. Consequently, p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b65376f95ef57875f65222f76a4a82b4
https://pubmed.ncbi.nlm.nih.gov/15281220
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2
The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition
Autor: J G, Heddle, S J, Blance, D B, Zamble, F, Hollfelder, D A, Miller, L M, Wentzell, C T, Walsh, A, Maxwell
Publikováno v: Journal of molecular biology. 307(5)
Microcin B17 is a 3.1-kDa bactericidal peptide; the putative target of this antibiotic is DNA gyrase. Microcin B17 has no detectable effect on gyrase-catalysed DNA supercoiling or relaxation activities in vitro and is unable to stabilise DNA cleavage
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a5f721adf4046f5f6317888dcf3b6b4
https://pubmed.ncbi.nlm.nih.gov/11292337
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3
In vivo transgenic mutation assays
Autor: J A, Heddle, S, Dean, T, Nohmi, M, Boerrigter, D, Casciano, G R, Douglas, B W, Glickman, N J, Gorelick, J C, Mirsalis, H J, Martus, T R, Skopek, V, Thybaud, K R, Tindall, N, Yajima
Publikováno v: Environmental and molecular mutagenesis. 35(3)
Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue. For regulatory applications, assays should be based on neutral genes, be generally available in several laboratories, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e02719958bc93ea898d15766add41be
https://pubmed.ncbi.nlm.nih.gov/10737959
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5
Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino(alpha)carboline
Autor: X B, Zhang, J S, Felton, J D, Tucker, C, Urlando, J A, Heddle
Publikováno v: Carcinogenesis. 17(10)
The heterocyclic amines produced during the cooking of meat, including amino(alpha)carboline (AalphaC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), are potent bacterial mutagens and are carcinogenic in rodents. PhIP is mutagenic in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61457a3fc13b2dc6333ae0401a75f5a5
https://pubmed.ncbi.nlm.nih.gov/8895498
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6
Why do stem cells exist?
Autor: J A, Heddle, L, Cosentino, G, Dawod, R R, Swiger, Y, Paashuis-Lew
Publikováno v: Environmental and molecular mutagenesis. 28(4)
Self-renewing tissues have a differentiation hierarchy such that the stem cells are the only permanent residents of the tissue, and it is in these cells that most cancerous mutations arise. The progeny of the stem cells either remain stem cells or en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3898e2dd9e15fa4fa6c29a9642c4b434
https://pubmed.ncbi.nlm.nih.gov/8991061
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7
A test for neutrality of mutations of the lacZ transgene
Autor: L, Cosentino, J A, Heddle
Publikováno v: Environmental and molecular mutagenesis. 28(4)
Neutral mutations are stable alterations in DNA that are neither beneficial nor damaging to the cell. Once a mutation is fixed in the DNA, the mutant frequency should increase to its maximum and plateau thereafter, provided that enough expression tim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::874e5d776c8d372554100548e9935653
https://pubmed.ncbi.nlm.nih.gov/8991058
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8
Measuring gene mutation in vivo
Autor: J A, Heddle, M A, Khan, C, Urlando, M E, Pagura
Publikováno v: Progress in clinical and biological research. 372
Both chromosomal aberrations and intragenic mutations are important in the activation of oncogenes and inactivation of antioncogenes. It is now possible to measure both types of mutational events in vivo in a single cell type. The results obtained in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e7aff44da48c8f9d30038bcf9ec193c
https://pubmed.ncbi.nlm.nih.gov/1956925
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