Zobrazeno 1 - 10
of 1 121
pro vyhledávání: '"J A, Harper"'
Autor:
Daniel C. Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King, Rajendra Tangallapally, Chan Lee, Clifford T. Gee, Lei Yang, Yong Li, Victoria C. Loudon, Ha Won Lee, Jason Ochoada, Darcie J. Miller, Thilina Jayasinghe, Joao A. Paulo, Stephen J. Elledge, J. Wade Harper, Taosheng Chen, Richard E. Lee, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-su
Externí odkaz:
https://doaj.org/article/6c50c513c918469eaf4c94f0f0e0d58b
Autor:
Michelle E. Watts, Richard M. Giadone, Alban Ordureau, Kristina M. Holton, J. Wade Harper, Lee L. Rubin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely limited treatment options. Identification of effective treatments has been limited in part by the lack of predictive animal models for complex human disorde
Externí odkaz:
https://doaj.org/article/07a719891bc64b85b0e8e936ef3f5f4e
Autor:
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Externí odkaz:
https://doaj.org/article/1474593e97d94a4ab73bc2bde059f30e
Autor:
Hankum Park, Frances V. Hundley, Qing Yu, Katherine A. Overmyer, Dain R. Brademan, Lia Serrano, Joao A. Paulo, Julia C. Paoli, Sharan Swarup, Joshua J. Coon, Steven P. Gygi, J. Wade Harper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Methods to assess organellar content are important. Here, Park et al develop a method for rapid isolation of early/sorting endosomes and demonstrate the application of the approach for analysis of endosomal proteomes and lipidomes, and for analysis o
Externí odkaz:
https://doaj.org/article/1a034683ce2a4dcfbf3aa019ef9440d8
Publikováno v:
The Cryosphere, Vol 15, Pp 897-907 (2021)
Temperature sensors installed in a grid of nine full-depth boreholes drilled in the southwestern ablation zone of the Greenland Ice Sheet recorded cooling in discrete sections of ice over time within the lowest third of the ice column in most borehol
Externí odkaz:
https://doaj.org/article/0da606f753a141d5a1df909f9cc9a665
Autor:
Thies H. Büscher, J. René Harper, Neeraja Sripada, Stanislav N. Gorb, Janice S. Edgerly, Sebastian Büsse
Publikováno v:
Diversity, Vol 15, Iss 3, p 415 (2023)
The diversity of true bugs gave rise to various lifestyles, including gaining advantage from other organisms. Plokiophilidae are cimicomorphan bugs that live in the silk constructions of other arthropods. One group, Embiophila, exclusively settles in
Externí odkaz:
https://doaj.org/article/a5963015af3c400db06ebcd15150e96a
Autor:
Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun, Silvia Piccinotti, Tobias Grass, Gustavo M. Parfitt, Joao A. Paulo, Fumiki Yanagawa, Takayuki Uozumi, Yasujiro Kiyota, J. Wade Harper, Lee L. Rubin
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 75-90 (2020)
Summary: Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown functions. It is unclear how dysregulation of these genes results in the
Externí odkaz:
https://doaj.org/article/1a013adc4b7343d58d3ed3b490fa2fb1
Publikováno v:
eLife, Vol 10 (2021)
Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by a dedicated surveillance machinery, leading to the assembly of an autophagosome around the
Externí odkaz:
https://doaj.org/article/40c546596589465a886eb24ae957f951
Autor:
M. Jacoupy, E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Most of over a thousand mitochondrial proteins are encoded by nuclear genes and must be imported from the cytosol. Little is known about the cytosolic events regulating mitochondrial protein import, partly due to the lack of appropriate tool
Externí odkaz:
https://doaj.org/article/e3de579c73004127a500e989a78a21a9
Publikováno v:
Journal of Small Animal Practice. 64:337-342