Zobrazeno 1 - 10
of 727
pro vyhledávání: '"J A, Gunn"'
Autor:
Michelle S Balaratnam, Fergus J Rugg-Gunn, Rachel Okin, Freya Powell, Stephen Prior, Panayiota Petrochilos, Dhiren Shivji, Salman Haider, Ali Alim-Marvasti, Arvind Chandratheva, Robert Simister, Charlie Lane, Roberto Macarimban, Diego Kaski, Bal Athwal, Rebecca Liu, Timothy Yates, Sanjeev Rajakulendran, Gerry Christofi, Jeremy Sandford, Alexis Ingram, Katherine Bluston, Caroline Weaver, Oluwaseun Odejide, George Glod, Gulsen Gungor, Edmund Nkrumah, Donal Markey, Gary Hotton, Katie Sidle, Jonathan Kennedy, Lisa Penniall, Helen Plum, Anthony Antoniou, Rakhee Prema, Nadia Jeffries, Carole Walters, Valerie L Stevenson, Malini Drysdale, Sabiha Tasnim, Shahrima Hussain, Lily Mackay, Ryan Baulk, Bianca IIii, David Egan, Adrian Capp, Patricia Turner, Christopher Turner
Publikováno v:
Clinical Medicine, Vol 24, Iss 6, Pp 100234- (2024)
Integrated care systems join up health and care services, so that people have the support they need, in the right place, at the right time. The aims include improving outcomes in healthcare, tackling inequalities in access and enhancing productivity
Externí odkaz:
https://doaj.org/article/944fb01b2de04bde97ad9aca51325398
Autor:
Patrick J G Gunn, Neeru A Vallabh, Robert Harper, Chan Ning Lee, Kenneth Yau, Alexander Delaney, Jay A L Richardson, Graham Freeman, Stephen Harthan, Vincent Dubois, Christopher Hemmerdinger
Publikováno v:
BMJ Open Ophthalmology, Vol 9, Iss 1 (2024)
Background Selective laser trabeculoplasty (SLT), a National Institute for Care and Health Excellence recommended first-line treatment for open-angle glaucoma and ocular hypertension, is increasingly delivered by optometrists. This retrospective mult
Externí odkaz:
https://doaj.org/article/5cf5aa212d20488e879938a78809a30f
Autor:
Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey, Meike Wiese, Hanneke Okkenhaug, Simon J. Boulton, Srinjan Basu, Simon Walker, Gabriele S. Kaminski Schierle, Geeta J. Narlikar, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show satellite transcripts in mouse embryonic stem cells drive HP1α into droplets in vitro and also control HP1α organisation and association with chromatin in vivo. Depleting the satellite transcripts converts heterochromatin into
Externí odkaz:
https://doaj.org/article/9694c15ea6ff49a7afe36d07b4947267
Autor:
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromat
Externí odkaz:
https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d36
Autor:
K. Afonin, A. Gallo, Y. Marandet, Ph. Moreau, G. Bodner, H. Bufferand, G. Ciraolo, C. Desgranges, P. Devynck, A. Diallo, J. Gaspar, C. Guillemaut, R. Guirlet, J.-P. Gunn, N. Fedorczak, T. Loarer, R. Lunsford, P. Manas, F. Nespoli, N. Rivals, P. Tamain, E.A. Unterberg, the WEST Team
Publikováno v:
Nuclear Fusion, Vol 63, Iss 12, p 126057 (2023)
Boron (B) powder injection is a potential alternative to glow discharge boronization as a wall conditioning method for tokamaks. This technique is currently being studied in WEST experiments, during which B powder is injected by an Impurity Powder Dr
Externí odkaz:
https://doaj.org/article/b94da6568e0c41aa933be4d722f7f953
Autor:
Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn
Publikováno v:
eLife, Vol 10 (2021)
The signalling pathways that maintain primed human pluripotent stem cells (hPSCs) have been well characterised, revealing a critical role for TGFβ/Activin/Nodal signalling. In contrast, the signalling requirements of naïve human pluripotency have n
Externí odkaz:
https://doaj.org/article/477038968eb04a52a24c1167301fe0f5
Chromodynamic Lattice Boltzmann Method for the Simulation of Drops, Erythrocytes, and other Vesicles
Publikováno v:
Communications in Computational Physics. 33:283-309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7c23edc1422ca6ed9aa561d39a69b6
https://doi.org/10.4208/cicp.oa-2022-0042
https://doi.org/10.4208/cicp.oa-2022-0042
Autor:
Olga Rosspopoff, Emmanuel Cazottes, Christophe Huret, Agnese Loda, Amanda J Collier, Miguel Casanova, Peter J Rugg-Gunn, Edith Heard, Jean-François Ouimette, Claire Rougeulle
Publikováno v:
Nucleic Acids Research. 51:2177-2194
X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b600f985f7fea03dd6b2c2548171a600
https://doi.org/10.1093/nar/gkad029
https://doi.org/10.1093/nar/gkad029
Autor:
Kristina Aldridge, Kimberly K. Cole, Amanda J. Moffitt Gunn, Dawn Peck, Desirée A. White, Shawn E. Christ
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss , Pp 100647- (2020)
Past murine studies of phenylketonuria (PKU) have documented significant effects on cerebellum at both the gross and cellular levels. The profile of neurocognitive and motor difficulties associated with early-treated PKU (ETPKU) is also consistent wi
Externí odkaz:
https://doaj.org/article/51acef2a21e540b586c870bf86d3f51b
Autor:
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions
Externí odkaz:
https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe