Zobrazeno 1 - 10
of 92
pro vyhledávání: '"J A, Gorter"'
Autor:
Eugenie Werbenko, David J. J. de Gorter, Simon Kleimann, Denise Beckmann, Vanessa Waltereit-Kracke, Julia Reinhardt, Fabienne Geers, Peter Paruzel, Uwe Hansen, Thomas Pap, Theresia E. B. Stradal, Berno Dankbar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bone resorption is highly dependent on the dynamic rearrangement of the osteoclast actin cytoskeleton to allow formation of actin rings and a functional ruffled border. Hem1 is a hematopoietic-specific subunit of the WAVE-complex which regul
Externí odkaz:
https://doaj.org/article/7158c6618faa4174a45185de02e0dde3
Autor:
J. N. Bootsma, M. Phoenix, J. J. M. Geytenbeek, K. Stadskleiv, J. W. Gorter, S. Fiske, B. J. Cunningham
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background It is challenging to reliably assess the language comprehension of children with severe motor and speech impairments using traditional assessment tools. The Computer Based instrument for Low motor Language Testing (C-BiLLT) aims t
Externí odkaz:
https://doaj.org/article/78f02c1e7437452581437a3daeaaf541
Autor:
Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in
Externí odkaz:
https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340
Publikováno v:
Australian Journal of Earth Sciences. 70:494-509
Autor:
C. M. Drion, J. van Scheppingen, A. Arena, K. W. Geijtenbeek, L. Kooijman, E. A. van Vliet, E. Aronica, J. A. Gorter
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Previous studies in various rodent epilepsy models have suggested that mammalian target of rapamycin (mTOR) inhibition with rapamycin has anti-epileptogenic potential. Since treatment with rapamycin produces unwanted side effects,
Externí odkaz:
https://doaj.org/article/d5e120f58da541bfac76e71af2dcc625
Effectiveness of innovative, gamified interventions (i.e., Augmented Reality, Computer-Based Cognitive Retraining [CBCR], and Virtual Reality [VR] in conjunction with a Serious Game) for cognitive training in paediatric ABI was evaluated. Studies wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999cf00711d5fba93e6cf577c82a62d
https://lirias.kuleuven.be/handle/20.500.12942/716118
https://lirias.kuleuven.be/handle/20.500.12942/716118
Autor:
Rizi Ai, Uwe Hansen, Johanna Intemann, Elsa Leitão, Toni Weinhage, Isabell Begemann, Joachim Kremerskothen, Anja Römer-Hillmann, Ho-Ryun Chung, Marianne Heitzmann, Thomas Pap, Hermann Pavenstädt, Hans P. Kiener, Na Li, Annika Krause, Wei Wang, Gilles Gasparoni, Berno Dankbar, Sylvia Müller, Corinna Wehmeyer, Denise Beckmann, Dirk Foell, Philip Rosenstiel, Bernhard Horsthemke, Thomas Kamradt, Adelheid Korb-Pap, Karl Nordström, Hans Schnittler, David J. J. de Gorter, Nico Lindemann, Jörn Walter, Gary S. Firestein, Xinyi Yang, Nina Gasparoni, Christopher Schröder, Jan Hillen, Milos Galic
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the ag
Autor:
David J. de Gorter, Marie O'Connor, Alexandre Deshiere, Martijn van Rosmalen, Szabolcs Fatrai, Jeroen Lammerts van Bueren, Cecile A. Geuijen
Publikováno v:
Cancer Research. 82:336-336
Introduction: MCLA-129 is an ADCC-enhanced IgG1 bispecific antibody that targets epidermal growth factor receptor (EGFR) and c-MET. The HGF/c-MET pathway is frequently upregulated in tumors that are resistant to EGFR tyrosine kinase inhibitors (TKIs)
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114475 (2014)
Bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor (TGF)-β family, transduce their signal through multiple components downstream of their receptors. Even though the components involved in the BMP signaling pathway have
Externí odkaz:
https://doaj.org/article/5a1b6ff1a7bd4387bd51c7b621721061
Autor:
Maarten van Dinther, Juan Zhang, Stella E Weidauer, Verena Boschert, Eva-Maria Muth, Achim Knappik, David J J de Gorter, Puck B van Kasteren, Christian Frisch, Thomas D Mueller, Peter ten Dijke
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62295 (2013)
Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST gene. Its gene product, Sclerostin, is a key negative regulator of bone formation and might therefore serve as a target for the anabolic treatment of
Externí odkaz:
https://doaj.org/article/f9a0fd8880214c629ade8f4eb736a565