Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J A, Drewe"'
Autor:
Diana L. Kunze, J. A. Drewe
Publikováno v:
Nucleus of the Solitary Tract ISBN: 9780429277214
Nucleus of the Solitary Tract
Nucleus of the Solitary Tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d889cfc24fc1dc14d524db7d21c9b6
https://doi.org/10.1201/9780429277214-20
https://doi.org/10.1201/9780429277214-20
Publikováno v:
Biophysical Journal. 66(1):179-190
In a chimeric, voltage-dependent K+ channel (CHM), the valine at position 369 and the leucine at position 374 interact within the pore or P-region to regulate ion permeation and block. Here we show that the point mutation, CHM V369L, abolished channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e634590b703bf512a0b7cca55d531b
Publikováno v:
Journal of Biological Chemistry. 268:13799-13804
The aqueous pore (P-region) of homotetrameric voltage-gated K+ channels has been modeled as a radially symmetrical eight-stranded antiparallel beta-barrel to which each of the four subunits contributes equally. This model has hydrogen bonding between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d39bfdf34954f1b15d654eb78a640b7
https://doi.org/10.1016/s0021-9258(19)85173-6
https://doi.org/10.1016/s0021-9258(19)85173-6
Publikováno v:
Archives of disease in childhood. 37(196)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8f72d46d13790d8a7b8bcd77b45def
https://pubmed.ncbi.nlm.nih.gov/21032398
https://pubmed.ncbi.nlm.nih.gov/21032398
Autor:
J. A. Drewe, Paul W. Groundwater
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93f4c750ab38245a26c2d3192e1e968c
https://doi.org/10.1002/chin.199732123
https://doi.org/10.1002/chin.199732123
Publikováno v:
FEBS Letters. 278:55-60
A novel member of the RCK family of rat brain K + channels, called RCK2, has been sequenced and expressed in Xenopus oocytes. The K + currents were voltage-dependent, activated within 20 ms (at 0 mV), did not inactivate in 5 s, and had a single chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba375534fe27186488e440bdfb80f49
https://doi.org/10.1016/0014-5793(91)80082-e
https://doi.org/10.1016/0014-5793(91)80082-e
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(3)
Pentylenetetrazole (PTZ) is a central nervous system convulsant that is thought, based on binding studies, to act at the picrotoxin (PTX) site of the gamma-aminobutyric acid type A (GABA(A)) receptor. In the present study, we have investigated the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae4bb52464f877135299c8c2509da63b
https://pubmed.ncbi.nlm.nih.gov/11504794
https://pubmed.ncbi.nlm.nih.gov/11504794
Autor:
Rolf H. Joho, Arthur M. Brown, Mauruzio Taglialatela, Glenn E. Kirsch, J. A. Drewe, H. A. Hartmann
Publikováno v:
Science. 251:942-944
The structure of the ion conduction pathway or pore of voltage-gated ion channels is unknown, although the linker between the membrane spanning segments S5 and S6 has been suggested to form part of the pore in potassium channels. To test whether this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b031f0be0e7385d96143ad1e104ae9
https://doi.org/10.1126/science.2000495
https://doi.org/10.1126/science.2000495
Autor:
J E, Hawkinson, M, Acosta-Burruel, K C, Yang, D J, Hogenkamp, J S, Chen, N C, Lan, J A, Drewe, E R, Whittemore, R M, Woodward, R B, Carter, R B, Upasani
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(1)
Neuroactive steroids are positive allosteric modulators of gamma-aminobutyric acidA (GABAA) receptor complexes. Synthetic modification generally does not increase neuroactive steroid potency beyond that of the naturally occurring progesterone metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::078f40ec2a39b1f469647338c8360470
https://pubmed.ncbi.nlm.nih.gov/9765338
https://pubmed.ncbi.nlm.nih.gov/9765338
Autor:
A P, Tamiz, E R, Whittemore, Z L, Zhou, J C, Huang, J A, Drewe, J C, Chen, S X, Cai, E, Weber, R M, Woodward, J F, Keana
Publikováno v:
Journal of medicinal chemistry. 41(18)
A series of bis(phenylalkyl)amines, structural analogues of ifenprodil and nylidrin, were synthesized and tested for antagonism of N-methyl-D-aspartate (NMDA) receptors. Potency and subunit selectivity were assayed by electrical recordings in Xenopus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f7612ff0e55b293d780346602b86aca
https://pubmed.ncbi.nlm.nih.gov/9719603
https://pubmed.ncbi.nlm.nih.gov/9719603