Zobrazeno 1 - 10
of 531
pro vyhledávání: '"J A, Browne"'
Autor:
Alessia Visconti, Niccolò Rossi, Albert Bondt, Agnes Hipgrave Ederveen, Gaurav Thareja, Carolien A. M. Koeleman, Nisha Stephan, Anna Halama, Hannah J. Lomax-Browne, Matthew C. Pickering, Xu-jie Zhou, Manfred Wuhrer, Karsten Suhre, Mario Falchi
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA gly
Externí odkaz:
https://doaj.org/article/ecaa1900ce4c4ce1bc7ee82e4afe3d17
Autor:
Mercedes Porosnicu, Anderson O’Brien Cox, Joshua D. Waltonen, Paul M. Bunch, Ralph D’Agostino, Thomas W. Lycan, Richard Taylor, Dan W. Williams, Xiaofei Chen, Kirtikar Shukla, Brian E. Kouri, Tiffany Walker, Gregory Kucera, Hafiz S. Patwa, Christopher A. Sullivan, J. Dale Browne, Cristina M. Furdui
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Translational RelevanceEvaluation of targeted therapies is urgently needed for the majority of patients with metastatic/recurrent head and neck squamous cell carcinoma (HNSCC) who progress after immunochemotherapy. Erlotinib, a targeted inhibitor of
Externí odkaz:
https://doaj.org/article/c47f8d45cae64e029522153138412aa9
Autor:
Nicholas R. Medjeral-Thomas, Hilary Moffitt, Hannah J. Lomax-Browne, Nicholas Constantinou, Tom Cairns, H. Terence Cook, Matthew C. Pickering
Publikováno v:
Kidney International Reports, Vol 4, Iss 10, Pp 1387-1400 (2019)
Introduction: Therapeutic agents that target complement are increasingly available for glomerular diseases. However, the mechanisms linking glomerular complement deposition with inflammation and damage are incompletely understood. Complement factor H
Externí odkaz:
https://doaj.org/article/88639a1684f5461493008da5093936a6
Autor:
A. Vestering, M. N. Bekker, D. E. Grobbee, R. van der Graaf, A. Franx, N. M. T. Crombag, J. L. Browne
Publikováno v:
Reproductive Health, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Calcium and low-dose aspirin are two potential approaches for primary prevention of hypertensive disorders of pregnancy (HDP). This study aimed to explore the acceptability, views and preferences of pregnant women and primary heal
Externí odkaz:
https://doaj.org/article/b25eeea775af4d19b5055032a84c1de5
Autor:
Nicholas A. T. Irwin, Benjamin J. E. Martin, Barry P. Young, Martin J. G. Browne, Andrew Flaus, Christopher J. R. Loewen, Patrick J. Keeling, LeAnn J. Howe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Dinoflagellates are known to use dinoflagellate-viral-nucleoproteins (DVNPs) in place of histones, yet this evolutionary transition is not well understood. Here, Irwin et al. use yeast expressing DVNP to show that DVNP displaces histones and that his
Externí odkaz:
https://doaj.org/article/52638ea85b694df989579b49775e0ee6
Autor:
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering
Publikováno v:
Kidney International Reports, Vol 3, Iss 2, Pp 426-438 (2018)
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal
Externí odkaz:
https://doaj.org/article/343f738fd1b549c1931233d31f58310f
Autor:
B. A. McGivney, M. E. Griffin, K. F. Gough, C. L. McGivney, J. A. Browne, E. W. Hill, L. M. Katz
Publikováno v:
BMC Veterinary Research, Vol 13, Iss 1, Pp 1-8 (2017)
Abstract Background Circulating miRNAs (ci-miRNAs) are endogenous, non-coding RNAs emerging as potential diagnostic biomarkers. Equine miRNAs have been previously identified including subsets of tissue-specific miRNAs. In order to investigate ci-miRN
Externí odkaz:
https://doaj.org/article/7997db049e6a499fb9fe12456705f62f
Autor:
Hannah J. Lomax-Browne, Nicholas R. Medjeral-Thomas, Sean J. Barbour, Jack Gisby, Heedeok Han, Andrew S. Bomback, Fernando C. Fervenza, Thomas H. Cairns, Richard Szydlo, Sven-Jean Tan, Stephen D. Marks, Aoife M. Waters, Gerald B. Appel, Vivette D. D’Agati, Sanjeev Sethi, Cynthia C. Nast, Ingeborg Bajema, Charles E. Alpers, Agnes B. Fogo, Christoph Licht, Fadi Fakhouri, Daniel C. Cattran, James E. Peters, H. Terence Cook, Matthew C. Pickering
Publikováno v:
Clin J Am Soc Nephrol
Clinical Journal of the American Society of Nephrology, 17(7), 994-1007. AMER SOC NEPHROLOGY
Clinical Journal of the American Society of Nephrology, 17(7), 994-1007. AMER SOC NEPHROLOGY
Background and objectives: C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition. These conditions are heterogeneous in outcome, but approximately 50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c04113748d9189af403870eb155fc5
https://doi.org/10.2215/cjn.16801221
https://doi.org/10.2215/cjn.16801221
Autor:
Anna Török, Martin J. G. Browne, Jordina C. Vilar, Indu Patwal, Timothy Q. DuBuc, null Febrimarsa, Erwan Atcheson, Uri Frank, Sebastian G. Gornik, Andrew Flaus
Publikováno v:
Development. 150
Many animals achieve sperm chromatin compaction and stabilisation by replacing canonical histones with sperm nuclear basic proteins (SNBPs) such as protamines during spermatogenesis. Hydrozoan cnidarians and echinoid sea urchins lack protamines and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b2ae58cca87756b375e345e088a1442
https://doi.org/10.1242/dev.201058
https://doi.org/10.1242/dev.201058
Autor:
Amy-Claire McLoughlin, H. Terence Cook, Isabel Y. Pappworth, Timothy H.J. Goodship, B. Paul Morgan, Valerie Wilson, Harriet Denton, Svetlana Hakobyan, Edwin K.S. Wong, David J. Kavanagh, Daniel P. Gale, Katie Cooke, Matthew C. Pickering, Sophie Ward, Claire L. Harris, Hannah J. Lomax-Browne, Martin Christian, Heather Maxwell, Sally Johnson, Stephen D. Marks, Roger D. G. Malcomson, Paul McAlinden, Grant Richardson, Kevin J. Marchbank
Publikováno v:
Clin J Am Soc Nephrol
BACKGROUND AND OBJECTIVES: Membranoproliferative GN and C3 glomerulopathy are rare and overlapping disorders associated with dysregulation of the alternative complement pathway. Specific etiologic data for pediatric membranoproliferative GN/C3 glomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a724e600064d721ca41d426caf29c2b9
https://doi.org/10.2215/cjn.00320121
https://doi.org/10.2215/cjn.00320121