Výsledky vyhledávání - "J A, Borghans"

Akademický článek

First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator

Autor: Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld

Publikováno v: Clinical and Translational Science, Vol 16, Iss 8, Pp 1381-1395 (2023)

Abstract Soluble guanylate cyclase (sGC) and its product, cyclic guanosine monophosphate, play a role in learning and memory formation. Zagociguat (CY6463) is a novel stimulator of sGC being developed for the treatment of neurodegenerative disease. S

Externí odkaz: https://doaj.org/article/605ef30c9d6a4f4dba035897267df19d

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Akademický článek

Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial

Autor: Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas, Geert J Groeneveld, Robert J Doll

Publikováno v: JMIR Formative Research, Vol 5, Iss 12, p e31890 (2021)

BackgroundAlthough electrocardiography is the gold standard for heart rate (HR) recording in clinical trials, the increasing availability of smartwatch-based HR monitors opens up possibilities for drug development studies. Smartwatches allow for inex

Externí odkaz: https://doaj.org/article/fe94b180e6264e17bc5369110d805b11

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Biperiden challenge model in healthy elderly as proof-of-pharmacology tool

Autor: Joop M. A. van Gerven, Rik F E Stuurman, Geert Jan Groeneveld, Charlotte Bakker, Michiel J van Esdonk, Laura G J M Borghans, Marieke L. de Kam

Publikováno v: Journal of Clinical Pharmacology
Journal of Clinical Pharmacology, 61(11), 1466-1478. WILEY

Selective M1 muscarinic acetylcholine receptor (mAChR) agonists are being developed as symptomatic treatment for neurodegenerative and neuropsychiatric disorders that lead to cognitive dysfunction. Demonstrating cognition‐enhancing effects in early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd374d56c19e16c7f20e7d85f3f0aaf
https://hdl.handle.net/1887/3276258

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Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial (Preprint)

Autor: Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas, Geert J Groeneveld, Robert J Doll

BACKGROUND Although electrocardiography is the gold standard for heart rate (HR) recording in clinical trials, the increasing availability of smartwatch-based HR monitors opens up possibilities for drug development studies. Smartwatches allow for ine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bc0c714f2c260eef10d1f8ca0f4cb05
https://doi.org/10.2196/preprints.31890

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How specific should immunological memory be?

Autor: J A, Borghans, A J, Noest, R J, De Boer

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(2)

Protection against infection hinges on a close interplay between the innate immune system and the adaptive immune system. Depending on the type and context of a pathogen, the innate system instructs the adaptive immune system to induce an appropriate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9952de6b8f671d4e898ac0c967b543f6
https://pubmed.ncbi.nlm.nih.gov/10395642

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T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model

Autor: J A, Borghans, R J, De Boer, E, Sercarz, V, Kumar

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(3)

T cell vaccination (TCV) is a method to induce resistance to autoimmune diseases by priming the immune system with autoreactive T cells. This priming evokes an anti-idiotypic regulatory T cell response to the receptors on the autoreactive T cells. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::930121ad587ada37b53b26e00dfbe6a8
https://pubmed.ncbi.nlm.nih.gov/9686566

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