Zobrazeno 1 - 10
of 91
pro vyhledávání: '"J A, Borghans"'
Autor:
Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1381-1395 (2023)
Abstract Soluble guanylate cyclase (sGC) and its product, cyclic guanosine monophosphate, play a role in learning and memory formation. Zagociguat (CY6463) is a novel stimulator of sGC being developed for the treatment of neurodegenerative disease. S
Externí odkaz:
https://doaj.org/article/605ef30c9d6a4f4dba035897267df19d
Autor:
Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas, Geert J Groeneveld, Robert J Doll
Publikováno v:
JMIR Formative Research, Vol 5, Iss 12, p e31890 (2021)
BackgroundAlthough electrocardiography is the gold standard for heart rate (HR) recording in clinical trials, the increasing availability of smartwatch-based HR monitors opens up possibilities for drug development studies. Smartwatches allow for inex
Externí odkaz:
https://doaj.org/article/fe94b180e6264e17bc5369110d805b11
Autor:
Joop M. A. van Gerven, Rik F E Stuurman, Geert Jan Groeneveld, Charlotte Bakker, Michiel J van Esdonk, Laura G J M Borghans, Marieke L. de Kam
Publikováno v:
Journal of Clinical Pharmacology
Journal of Clinical Pharmacology, 61(11), 1466-1478. WILEY
Journal of Clinical Pharmacology, 61(11), 1466-1478. WILEY
Selective M1 muscarinic acetylcholine receptor (mAChR) agonists are being developed as symptomatic treatment for neurodegenerative and neuropsychiatric disorders that lead to cognitive dysfunction. Demonstrating cognition‐enhancing effects in early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd374d56c19e16c7f20e7d85f3f0aaf
https://hdl.handle.net/1887/3276258
https://hdl.handle.net/1887/3276258
Autor:
Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas, Geert J Groeneveld, Robert J Doll
BACKGROUND Although electrocardiography is the gold standard for heart rate (HR) recording in clinical trials, the increasing availability of smartwatch-based HR monitors opens up possibilities for drug development studies. Smartwatches allow for ine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc0c714f2c260eef10d1f8ca0f4cb05
https://doi.org/10.2196/preprints.31890
https://doi.org/10.2196/preprints.31890
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(2)
Protection against infection hinges on a close interplay between the innate immune system and the adaptive immune system. Depending on the type and context of a pathogen, the innate system instructs the adaptive immune system to induce an appropriate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9952de6b8f671d4e898ac0c967b543f6
https://pubmed.ncbi.nlm.nih.gov/10395642
https://pubmed.ncbi.nlm.nih.gov/10395642
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(3)
T cell vaccination (TCV) is a method to induce resistance to autoimmune diseases by priming the immune system with autoreactive T cells. This priming evokes an anti-idiotypic regulatory T cell response to the receptors on the autoreactive T cells. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::930121ad587ada37b53b26e00dfbe6a8
https://pubmed.ncbi.nlm.nih.gov/9686566
https://pubmed.ncbi.nlm.nih.gov/9686566
Autor:
van Kraaij, Sebastiaan J. W.1,2 (AUTHOR), Gal, Pim1,2 (AUTHOR), Borghans, Laura G. J. M.1 (AUTHOR), Klaassen, Erica S.1 (AUTHOR), Dijkstra, Francis1,2 (AUTHOR), Winrow, Christopher3 (AUTHOR), Glasser, Chad3 (AUTHOR), Groeneveld, Geert Jan1,2 (AUTHOR) ggroeneveld@chdr.nl
Publikováno v:
CTS: Clinical & Translational Science. Aug2023, Vol. 16 Issue 8, p1381-1395. 15p.
Publikováno v:
Minerva medica. 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d60b4e61db41a86afc05911b643787c6
https://pubmed.ncbi.nlm.nih.gov/13802789
https://pubmed.ncbi.nlm.nih.gov/13802789
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 101(29)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95207f17762e07b8d381c376d26c0267
https://pubmed.ncbi.nlm.nih.gov/13477300
https://pubmed.ncbi.nlm.nih.gov/13477300
Publikováno v:
Tropical and geographical medicine. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::114e4082c13bdd1d858a3547e0fe1387
https://pubmed.ncbi.nlm.nih.gov/13802790
https://pubmed.ncbi.nlm.nih.gov/13802790