Zobrazeno 1 - 10
of 235
pro vyhledávání: '"J A, Blackwell"'
Autor:
Simon C.C. Lucas, J. Henry Blackwell, Sarah H. Hewitt, Hannah Semple, Benjamin C. Whitehurst, Hua Xu
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100142- (2024)
Covalent hits for drug discovery campaigns are neither fantastic beasts nor mythical creatures, they can be routinely identified through electrophile-first screening campaigns using a suite of different techniques. These include biophysical and bioch
Externí odkaz:
https://doaj.org/article/27d924496e8440509ecb62d8a6268f4d
Molecules displaying an α-trialkyl-α-tertiary amine motif provide access to an important and versatile area of biologically relevant chemical space but are challenging to access through existing synthetic methods. Here, we report an operationally s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66a07268d6338a06a522fe129781e59
Publikováno v:
Angewandte Chemie. 131:9152-9157
Reported is the discovery of an approach to functionalize secondary alkylamines using 2-halobenzoic acids as aryl-transfer reagents. These reagents promote an unusually mild carboxylate-assisted oxidative addition to alkylamine-derived palladacycles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291bc4371aa999a1f13afbe7d8f76e9d
https://doi.org/10.1002/ange.201902838
https://doi.org/10.1002/ange.201902838
Publikováno v:
Journal of the American Chemical Society. 143(3)
The all-alkyl α-tertiary amino acid scaffold represents an important structural feature in many biologically and pharmaceutically relevant molecules. Syntheses of this class of molecule, however, often involve multiple steps and require activating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3c6146619a41bd27fbe032839be11b
https://pubmed.ncbi.nlm.nih.gov/33428383
https://pubmed.ncbi.nlm.nih.gov/33428383
Publikováno v:
African Journal of Pure and Applied Chemistry. 12:34-37
Continuous extraction of bitter kola nuts, followed by liquid-liquid extraction and flash column chromatography leads to the isolation of garcinoic acid (i¤-tocotrienoloic acid), as the main lipophilic component in a 0.8% yield of the initial dry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff06cbf7b437f482ef5b64bc95c526ae
https://doi.org/10.5897/ajpac2018.0752
https://doi.org/10.5897/ajpac2018.0752
Autor:
P. D. McKercher, Dean O. Cliver, Norman D. Heidelbaugh, J. H. Blackwell, Edward P. Larkin, J. J. Callis, Donald W. Thayer
Publikováno v:
Journal of food protection. 48(8)
All viruses known to be normally transmissible through foods and of concern to human health emanate from the human intestine. The outbreaks of hepatitis A and recently of gastroenteritis attributed to Norwalk-like viruses most likely developed from f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5effd838980f6b7808a0752cd259b56
https://pubmed.ncbi.nlm.nih.gov/30939662
https://pubmed.ncbi.nlm.nih.gov/30939662
Publikováno v:
Angewandte Chemie (International ed. in English). 58(27)
Reported is the discovery of an approach to functionalize secondary alkylamines using 2-halobenzoic acids as aryl-transfer reagents. These reagents promote an unusually mild carboxylate-assisted oxidative addition to alkylamine-derived palladacycles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df1788691ca897b0e9bddcf5eeb30c03
https://pubmed.ncbi.nlm.nih.gov/31042003
https://pubmed.ncbi.nlm.nih.gov/31042003
Publikováno v:
Journal of food protection. 41(9)
Dried casein produced from pasteurized milk of dairy cows infected with foot-and-mouth disease (FMD) virus retained infectivity for cattle in one of seven tests for 42 days of storage at 25 C. Thus, infections FMD virus can persist after pasteurizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac0204227cde3deca4246422e956fd4
https://pubmed.ncbi.nlm.nih.gov/30795079
https://pubmed.ncbi.nlm.nih.gov/30795079
Publikováno v:
Cross-Cultural Research. 48:326-335
This study investigated the effects of perceived maternal and paternal acceptance, and parental power and prestige on university students’ psychological adjustment. The sample consisted of 315 students (17% males) ages 18 through 49 years ( M = 23.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b659a3ef2b46ce98daf93413081118
https://doi.org/10.1177/1069397114528677
https://doi.org/10.1177/1069397114528677
Publikováno v:
JAWRA Journal of the American Water Resources Association. 49:1412-1420
The purpose of this project was to assess the effect of estimating total suspended solids (TSS) concentrations from turbidity on TSS loads for streams in the Robeson Creek watershed. Discharge was monitored continuously and base-flow grab and storm e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::070f569fb255d8ed8f88d48a2134a489
https://doi.org/10.1111/jawr.12094
https://doi.org/10.1111/jawr.12094